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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_1870 [new locus tag: SPH_RS09115 ]
  • pan locus tag?: PNEUPAN003189000
  • symbol: SPH_1870
  • pan gene symbol?: secA-2
  • synonym: secA2
  • product: preprotein translocase subunit SecA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_1870 [new locus tag: SPH_RS09115 ]
  • symbol: SPH_1870
  • product: preprotein translocase subunit SecA
  • replicon: chromosome
  • strand: -
  • coordinates: 1726791..1729163
  • length: 2373
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    GTGTTTAGACGTTTAGGTCAAGATTTCCAGCTTAGGAAAGTGAAAAAGATTTTAAAGCAG
    ATTAATGCCCTGAAAGGCAAGATGTCCTCTCTTTCGGATCAAGAATTAGTAGCTAAAACA
    GTAGAGTTTCGTCAGCGTCTTTCCGAGGGAGAAAGTCTAGACGATATTTTGGTTGAAGCT
    TTTGCTGTGGTGCGTGAAGCAGATAAGCGGATTTTAGGGATGTTCCCCTATGATGTTCAA
    GTCATGGGAGCTATTGTCATGCACTATGGAAATGTTGCTGAGATGAATACGGGGGAAGGT
    AAGACCTTGACAGCTACCATGCCTGTCTATTTGAACGCTTTTTCAGGAGAAGGAGTGATG
    GTTGTGACTCCTAATGAGTATTTATCAAAGCGTGATGCCGAGGAAATGGGCCAAGTTTAT
    CGTTTTCTAGGATTGACCATTGGTGTACCATTTACGGAAGATCCAAAGAAGGAAATGAAA
    GCTGAAGAAAAGAAGCTTATCTATGCTTCGGATATCATCTACACAACCAATAGTAATTTA
    GGTTTTGATTATCTAAATGATAACCTAGCCTCGAATGAAGAAGGTAAGTTTTTACGACCG
    TTTAACTATGTGATTATTGATGAAATTGATGATATCTTGCTTGATAGTGCACAAACTCCT
    CTGATTATTGCGGGTTCTCCTCGTGTTCAGTCTAATTACTATGCGATCATTAATACACTT
    GTAACAACCTTGGTCGAAGGAGAGGATTATATCTTTAAAGAGGAGAAAGAGGAGGTTTGG
    CTCACTACTAAGGGGGCCAAGTCTGCTGAGAATTTCCTAGGGATTGATAATTTATACAAG
    GAAGAGCATGCGTCTTTTGCTCGTCATTTGGTTTATGCGATTCGAGCTCATAAGCTCTTT
    ACTAAAGATAAGGACTATATCATTCGTGGAAATGAGATGGTACTGGTTGATAAGGGAACA
    GGGCGTCTAATGGAAATGACTAAACTTCAAGGAGGTCTCCATCAGGCTATTGAAGCCAAG
    GAACATGTCAAATTATCTCCTGAGACGCGGGCTATGGCCTCGATCACCTATCAGAGTCTT
    TTTAAGATGTTTAATAAGATATCTGGTATGACAGGGACAGGTAAGGTCGCGGAAAAAGAG
    TTTATTGAAACTTATAATATGTCTGTAGTACGCATTCCAACCAATCGTCCGAGACAACGG
    ATTGACTATCCAGATAATCTATATATCACTTTACCTGAAAAAGTGTATGCATCCTTGGAG
    TACATCAAGCAATACCATGCTAAGGGAAATCCCTTACTCGTTTTTGTAGGCTCAGTTGAA
    ATGTCTCAACTCTATTCGTCTCTCTTGTTTCGTGAAGGGATTGCCCATAATGTCCTAAAT
    GCTAATAATGCGGCGCGTGAGGCTCAGATTATCTCCGAGTCAGGTCAGATGGGGGCTGTG
    ACAGTGGCTACCTCTATGGCAGGACGTGGTACGGATATCAAGCTTGGTAAAGGAGTTGCA
    GAGCTTGGGGGCTTGATTGTTATTGGGACTGAGCGAATGGAAAGTCAGCGGATCGACCTA
    CAAATTCGTGGCCGTTCTGGTCGTCAGGGAGATCCTGGTATGAGTAAATTTTTTGTATCC
    TTAGAGGATGATGTTATCAAGAAGTTTGGTCCATCTTGGGTGCATAAAAAGTACAAAGAC
    TATCAGGTTCAAGATATGACTCAACCGGAAGTATTGAAAGGTCGTAAATACCGGAAACTA
    GTCGAAAAGGCTCAGCATGCCAGTGATAGTGCTGGACGTTCAGCACGTCGTCAGACTCTG
    GAGTATGCTGAAAGTATGAATATACAACGGGATATAGTCTATAAAGAGAGAAATCGTCTA
    ATAGATGGTTCTCGTGACTTAGAGGATGTTGTTGTGGATATCATTGAGAGATATACAGAA
    GAGGTAGCGGCTGATCACTATGCTAGTCGTGAATTATTGTTTCACTTTATTGTGACCAAT
    ATTAGTTTTCATGTTAAAGAGGTTCCAGATTATATAGATGTAACTGACAAAACTGCAGTT
    CGTAGCTTTATGAAGCAGGTGATTGATAAAGAACTTTCTGAAAAGAAAGAATTACTTAAT
    CAACATGACTTATATGAACAGTTTTTACGACTTTCACTGCTTAAAGCCATTGATGACAAC
    TGGGTAGAGCAGGTAGACTATCTACAACAGCTATCCATGGCTATCGGTGGTCAATCTGCT
    AGTCAGAAAAATCCAATCGTAGAGTACTATCAAGAAGCCTACGCGGGCTTTGAAGCTATG
    AAAGAACAAATCCGTGCGGATATGGTGCGTAATCTCCTGATGGGGCTGGTTGAGGTCACT
    CCAAAAGGTGAAATCGTGACTCATTTTCCATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2373

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_1870 [new locus tag: SPH_RS09115 ]
  • symbol: SPH_1870
  • description: preprotein translocase subunit SecA
  • length: 790
  • theoretical pI: 6.06513
  • theoretical MW: 89758.1
  • GRAVY: -0.343671

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein fate Protein and peptide secretion and trafficking accessory Sec system translocase SecA2 (TIGR03714; HMM-score: 1256.6)
    and 3 more
    Genetic information processing Protein fate Protein and peptide secretion and trafficking preprotein translocase, SecA subunit (TIGR00963; HMM-score: 795.6)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking accessory Sec system translocase SecA2 (TIGR04397; HMM-score: 765.5)
    accessory Sec system translocase SecA2 (TIGR04221; HMM-score: 515.8)
  • TheSEED  :
    • Protein export cytoplasm protein SecA2 ATPase RNA helicase (TC 3.A.5.1.1)
    Membrane Transport Protein translocation across cytoplasmic membrane SecY2-SecA2 Specialized Transport System  Protein export cytoplasm protein SecA2 ATPase RNA helicase (TC 3.A.5.1.1)
  • PFAM:
    P-loop_NTPase (CL0023) SecA_DEAD; SecA DEAD-like domain (PF07517; HMM-score: 368)
    and 5 more
    no clan defined SecA_SW; SecA Wing and Scaffold domain (PF07516; HMM-score: 110.9)
    SecA_PP_bind; SecA preprotein cross-linking domain (PF01043; HMM-score: 100.4)
    P-loop_NTPase (CL0023) DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 33)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 20.3)
    Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 18.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.94
    • Cytoplasmic Membrane Score: 2.06
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.602
    • Cytoplasmic Membrane Score: 0.3224
    • Cell wall & surface Score: 0.0033
    • Extracellular Score: 0.0723
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001699
    • TAT(Tat/SPI): 0.000422
    • LIPO(Sec/SPII): 0.000459
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFRRLGQDFQLRKVKKILKQINALKGKMSSLSDQELVAKTVEFRQRLSEGESLDDILVEAFAVVREADKRILGMFPYDVQVMGAIVMHYGNVAEMNTGEGKTLTATMPVYLNAFSGEGVMVVTPNEYLSKRDAEEMGQVYRFLGLTIGVPFTEDPKKEMKAEEKKLIYASDIIYTTNSNLGFDYLNDNLASNEEGKFLRPFNYVIIDEIDDILLDSAQTPLIIAGSPRVQSNYYAIINTLVTTLVEGEDYIFKEEKEEVWLTTKGAKSAENFLGIDNLYKEEHASFARHLVYAIRAHKLFTKDKDYIIRGNEMVLVDKGTGRLMEMTKLQGGLHQAIEAKEHVKLSPETRAMASITYQSLFKMFNKISGMTGTGKVAEKEFIETYNMSVVRIPTNRPRQRIDYPDNLYITLPEKVYASLEYIKQYHAKGNPLLVFVGSVEMSQLYSSLLFREGIAHNVLNANNAAREAQIISESGQMGAVTVATSMAGRGTDIKLGKGVAELGGLIVIGTERMESQRIDLQIRGRSGRQGDPGMSKFFVSLEDDVIKKFGPSWVHKKYKDYQVQDMTQPEVLKGRKYRKLVEKAQHASDSAGRSARRQTLEYAESMNIQRDIVYKERNRLIDGSRDLEDVVVDIIERYTEEVAADHYASRELLFHFIVTNISFHVKEVPDYIDVTDKTAVRSFMKQVIDKELSEKKELLNQHDLYEQFLRLSLLKAIDDNWVEQVDYLQQLSMAIGGQSASQKNPIVEYYQEAYAGFEAMKEQIRADMVRNLLMGLVEVTPKGEIVTHFP

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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