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HU-OH
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Hu17
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NCTC7466
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SPN034183
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SPN994038
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SPNA45
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TCH8431/19A
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Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 06-FEB-2015

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae ATCC 700669
  • locus tag: SPN23F04790 [new locus tag: SPN23F_RS02450 ]
  • pan locus tag?: PNEUPAN001394000
  • symbol: blpH
  • pan gene symbol?: blpH
  • synonym:
  • product: sensor histidine kinase BlpH

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN23F04790 [new locus tag: SPN23F_RS02450 ]
  • symbol: blpH
  • product: sensor histidine kinase BlpH
  • replicon: chromosome
  • strand: +
  • coordinates: 465493..466833
  • length: 1341
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGAACATTGCTTGGATATTGTTGTATACACTTGTTACTAATGGACTAGAAATTGTCATC
    TTCTTTAAGGTGGATGGAATTGATCTTACTTTCGAGAGGATTTTTAAGGCCTTTCTTTTT
    AAGATACTGTTGGCCTTTGTTTTTGTGATGATTAGCTATATAGTAGGAAATGTTTACCTA
    TCTTATTTTATGGAACCCTTGTACGGCATAGGCTTATCTTTCTTATTATTGAGAGGGCTT
    CCTAAAAAACTCCTTTTCTTTTATGGTCTCTTTCCAATGATATTGGTGAATCTCTTTTAT
    AGAGGAGTCTCCTATTTTGTGCTTCCATTTTTGGGACAAGGGCAAGTATATGATGGCTAC
    TCATTTACTGGGTTATGTATAATAATTTTCAATTTCTTCATTTCTCTAGCTTTTTTGAAA
    TGGTTGGACTACGATTTTACTAGCTTGAGAAAGGAGATTCTCGATAAAGCCTTTCAAAAG
    TCCCTGACTCAGATTAACTGGATAATGGGTGGCTACTATCTAGTCATGGAAAGTCTGTCT
    TTTTTTGAATATGAACAAAGTATTCAATCAAAGACTGTTCGCCATCTCATCCTAGTCTTT
    TACCTACTCTTTTTTATGGGGGTTATCAAGAAATTGGATACCTATTTGAAGGAAAAACTC
    TATGAGAGATTGGAACAAGAGCAGGCCCTGCGCTATAGAGATATGGAACGCTATAGTCGG
    CATATAGAGGAGCTTTACAAGGAAGTACGGAGCTTTCGTCATGATTATACCAACCTCTTG
    ACTAGCTTACGTCTGGGCATTGAAGAGGAGGATATGGAGCAGATAAAAGAGGTCTATGGC
    TCCGTCTTAAAGGATTCCAGTCAGAAATTGCAGAACAATAAATATGACCTGGGCAGATTG
    GTAAATATTCGTGATAAAGCCCTCAAAAGTCTTCTAGCAGGGAAATTTTTAAAAGCCAGA
    GATAAGAACATTGTCTTTAATGTCGAAGTTCCTGAGGAGATTCAGGTCGAGGGGATGAGT
    CTACTTGATTTTCTAACCATTGTGTCTATCCTTTGTGACAATGCTATTGAAGCCAGTGTG
    GAAGCTAGTCAACCTCATGTTTCAATCGCCTTTTTAAAAAATGGAGCACAGGAGACCTTT
    ATCATCGAAAACTCCATCAAAGAAGAGGGCATCGATATTTCTGAAATCTTCTCCTTTGGA
    GCCAGTTCTAAAGGGGAGGAGAGAGGAGTTGGTCTCTATACCGTCATGAAGATTGTGGAA
    AGCCATCCTAATACCAGTCTAAATACCACCTGTCAAAATCAAGTCTTTCGTCAGGTACTT
    ACTGTGATACATACAGAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1341

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN23F04790 [new locus tag: SPN23F_RS02450 ]
  • symbol: BlpH
  • description: sensor histidine kinase BlpH
  • length: 446
  • theoretical pI: 5.77378
  • theoretical MW: 51858.1
  • GRAVY: 0.210538

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED  :
    • Histidine kinase of the competence regulon ComD
    DNA Metabolism DNA uptake, competence Competence in Streptococci  Histidine kinase of the competence regulon ComD
  • PFAM:
    His_Kinase_A (CL0025) HATPase_c_5; GHKL domain (PF14501; HMM-score: 45.6)
    and 3 more
    no clan defined DUF4736; Domain of unknown function (DUF4736) (PF15883; HMM-score: 21)
    His_Kinase_A (CL0025) HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (PF02518; HMM-score: 19.9)
    no clan defined SPOB_a; Sensor_kinase_SpoOB-type, alpha-helical domain (PF14689; HMM-score: 14.8)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic Membrane
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 10
    • Cellwall Score: 0
    • Extracellular Score: 0
    • Internal Helices: 5
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0008
    • Cytoplasmic Membrane Score: 0.9873
    • Cell wall & surface Score: 0.0003
    • Extracellular Score: 0.0115
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.001028
    • TAT(Tat/SPI): 0.000046
    • LIPO(Sec/SPII): 0.017452
  • predicted transmembrane helices (TMHMM): 6

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CAR68324 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MNIAWILLYTLVTNGLEIVIFFKVDGIDLTFERIFKAFLFKILLAFVFVMISYIVGNVYLSYFMEPLYGIGLSFLLLRGLPKKLLFFYGLFPMILVNLFYRGVSYFVLPFLGQGQVYDGYSFTGLCIIIFNFFISLAFLKWLDYDFTSLRKEILDKAFQKSLTQINWIMGGYYLVMESLSFFEYEQSIQSKTVRHLILVFYLLFFMGVIKKLDTYLKEKLYERLEQEQALRYRDMERYSRHIEELYKEVRSFRHDYTNLLTSLRLGIEEEDMEQIKEVYGSVLKDSSQKLQNNKYDLGRLVNIRDKALKSLLAGKFLKARDKNIVFNVEVPEEIQVEGMSLLDFLTIVSILCDNAIEASVEASQPHVSIAFLKNGAQETFIIENSIKEEGIDISEIFSFGASSKGEERGVGLYTVMKIVESHPNTSLNTTCQNQVFRQVLTVIHTE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

A de Saizieu, C Gardès, N Flint, C Wagner, M Kamber, T J Mitchell, W Keck, K E Amrein, R Lange
Microarray-based identification of a novel Streptococcus pneumoniae regulon controlled by an autoinduced peptide.
J Bacteriol: 2000, 182(17);4696-703
[PubMed:10940007] [WorldCat.org] [DOI] (P p)Wei-Yun Wholey, Travis J Kochan, David N Storck, Suzanne Dawid
Coordinated Bacteriocin Expression and Competence in Streptococcus pneumoniae Contributes to Genetic Adaptation through Neighbor Predation.
PLoS Pathog: 2016, 12(2);e1005413
[PubMed:26840124] [WorldCat.org] [DOI] (I e)Morten Kjos, Eric Miller, Jelle Slager, Frank B Lake, Oliver Gericke, Ian S Roberts, Daniel E Rozen, Jan-Willem Veening
Expression of Streptococcus pneumoniae Bacteriocins Is Induced by Antibiotics via Regulatory Interplay with the Competence System.
PLoS Pathog: 2016, 12(2);e1005422
[PubMed:26840404] [WorldCat.org] [DOI] (I e)

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