PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 07-MAR-2025

⊟Summary

• organism: Streptococcus pneumoniae Hu17
• locus tag: SPNHU17_RS04575 [old locus tag: SPNHU17_00995 ]
• pan locus tag^?: PNEUPAN001936000
• symbol: SPNHU17_RS04575
• pan gene symbol^?: phoH
• synonym:
• product: PhoH family protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPNHU17_RS04575 [old locus tag: SPNHU17_00995 ]
• symbol: SPNHU17_RS04575
• product: PhoH family protein
• replicon: chromosome
• strand: +
• coordinates: 918197..919201
• length: 1005
• essential: unknown

⊟Accession numbers

• Location: NZ_CP020549 (918197..919201) NCBI
• BioCyc: SPNHU17_RS04575 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0838 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
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  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  
  TTGAAGGAACATTCAATAGACATTCAACTGAGTCATCCAGATGACCTGTTTCATCTTTTT
  GGTTCCAATGAACGCCATCTTCGTTTGATGGAAGAAGAGCTTGATGTTGTGATTCATGCT
  CGTACGGAGATTGTCCAGGTTTTGGGAGAAGAGTCTGCCTGTGAGGAAGCCCGTCAAGTT
  ATTCAGGCTTTGATGGTCTTGGTAAATCGTGGGATGACCGTTGGTACGCCAGATGTAGTC
  ACTGCGATTAGCATGGTCAAAAATGATGAAATTGACAAGTTTGTCGCCCTTTACGAAGAA
  GAAATTATCAAAGATAATACTGGGAAACCTATCCGTGTCAAAACCCTAGGGCAAAAGCTT
  TATGTGGACAGTGTCAAACAGCATGATGTGACCTTTGGAATTGGGCCAGCAGGTACAGGG
  AAGACCTTCCTTGCAGTGACCTTGGCAGTGACTGCCCTTAAACGTGGGCAAGTCAAGCGA
  ATTATCCTAACTCGTCCAGCGGTGGAAGCGGGAGAGAGTCTTGGATTTCTTCCGGGTGAT
  CTTAAGGAGAAGGTGGATCCTTACCTTCGTCCTGTTTACGATGCCTTGTATCAAATTCTT
  GGGAAAGACCAAACGACTCGTCTCATGGAGCGTGAAATTATCGAAATTGCGCCCCTTGCC
  TATATGCGTGGTCGGACCTTGGATGATGCCTTTGTCATTCTCGATGAGGCGCAAAATACG
  ACCATCATGCAGATGAAGATGTTCTTGACTCGTTTAGGTTTTCATTCTAAGATGATTGTC
  AATGGAGATATTAGTCAGATTGATCTGCCACGTAATGTCAAGTCCGGTTTGATTGATGCC
  CAAGAAAAGCTCAAGAACATTTACCAAATTGACTTTGTTCATTTTTCAGCTAAGGATGTG
  GTTCGCCATCCAGTTGTCGCTCAGATTATCCGAGCTTATGAACCAGCTCCAGTTAAAAAA
  GAAGAGAGTGAAGAATTAGAGTCTCAACCTCTGTCTGAAGGATAG
  60
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  1005
  

⊟Protein

⊟General

• locus tag: SPNHU17_RS04575 [old locus tag: SPNHU17_00995 ]
• symbol: SPNHU17_RS04575
• description: PhoH family protein
• length: 334
• theoretical pI: 5.30698
• theoretical MW: 37559.1
• GRAVY: -0.15509

⊟Function

• TIGRFAM:
  Genetic information processing DNA metabolism DNA replication, recombination, and repair putative DNA helicase (TIGR00376; EC 3.6.4.12; HMM-score: 15.8)
  Genetic information processing DNA metabolism DNA replication, recombination, and repair exodeoxyribonuclease V, alpha subunit (TIGR01447; EC 3.1.11.5; HMM-score: 15.5)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  P-loop_NTPase (CL0023) PhoH; PhoH-like protein (PF02562; HMM-score: 316.9)
  and 7 more
  AAA_30; AAA domain (PF13604; HMM-score: 27.5)
  AAA_19; AAA domain (PF13245; HMM-score: 24.3)
  IstB_IS21; IstB-like ATP binding protein (PF01695; HMM-score: 22.9)
  AAA_22; AAA domain (PF13401; HMM-score: 20.9)
  AAA_25; AAA domain (PF13481; HMM-score: 16.1)
  Zot; Zonular occludens toxin (Zot) (PF05707; HMM-score: 15.5)
  UvrD-helicase; UvrD/REP helicase N-terminal domain (PF00580; HMM-score: 15.3)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Cytoplasmic
  • Cytoplasmic Score: 9.97
  • Cytoplasmic Membrane Score: 0
  • Cellwall Score: 0.01
  • Extracellular Score: 0.02
  • Internal Helices: 0
• DeepLocPro: Cytoplasmic
  • Cytoplasmic Score: 0.9481
  • Cytoplasmic Membrane Score: 0.0413
  • Cell wall & surface Score: 0.0001
  • Extracellular Score: 0.0105
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.002196
  • TAT(Tat/SPI): 0.000162
  • LIPO(Sec/SPII): 0.000173
• predicted transmembrane helices (TMHMM): 0

⊟Accession numbers

• GI:
• RefSeq: WP_000658185 NCBI
• UniProt:

⊟Protein sequence

• MKEHSIDIQLSHPDDLFHLFGSNERHLRLMEEELDVVIHARTEIVQVLGEESACEEARQVIQALMVLVNRGMTVGTPDVVTAISMVKNDEIDKFVALYEEEIIKDNTGKPIRVKTLGQKLYVDSVKQHDVTFGIGPAGTGKTFLAVTLAVTALKRGQVKRIILTRPAVEAGESLGFLPGDLKEKVDPYLRPVYDALYQILGKDQTTRLMEREIIEIAPLAYMRGRTLDDAFVILDEAQNTTIMQMKMFLTRLGFHSKMIVNGDISQIDLPRNVKSGLIDAQEKLKNIYQIDFVHFSAKDVVRHPVVAQIIRAYEPAPVKKEESEELESQPLSEG

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0838 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications