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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Taiwan19F-14
  • locus tag: SPT_0073 [new locus tag: SPT_RS00370 ]
  • pan locus tag?: PNEUPAN000649000
  • symbol: SPT_0073
  • pan gene symbol?: araT
  • synonym:
  • product: putative aminotransferase A

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPT_0073 [new locus tag: SPT_RS00370 ]
  • symbol: SPT_0073
  • product: putative aminotransferase A
  • replicon: chromosome
  • strand: +
  • coordinates: 55737..56906
  • length: 1170
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGGACTTAACTAAGCGCTTTAATAAACAGTTAGATAAAATTCAAGTTTCGTTGATTCGT
    CAGTTTGACCAGGTTATTTCGGAGATTCCTGGGGTCTTGCGTTTGACCTTGGGGGAACCT
    GATTTTACAACGCCAGACCATGTCAAGGAGGCGGCCAAGCGAGCGATTGATCAGAACCAA
    TCCTACTATACAGGGATGAGTGGTCTGCTGACTCTACGTCAGGCGGCCAGTGATTTTGTT
    AAGGAAAAGTACCAACTGGACTATGCTCCTGAAAATGAAATCTTGGTCACTATCGGAGCG
    ACAGAGGCTTTATCTGCGACTTTGACGGCTATTTTGGAAGAGGGAGACAAGGTGCTCTTG
    CCAGCTCCTGCTTATCCGGGTTATGAACCGATTGTCAATCTAGTTGGGGCAGAAATTGTT
    GAGATTGATACGACTGAAAATGGTTTTGTCTTGACTCCTGAGATGTTGGAGAAGGCCATT
    TTGGAGCAGGGTGATAAGCTCAAGGCGGTTATTCTCAACTATCCAGCCAATCCGACAGGA
    ATTACCTACAGTCGAGAGCAGTTAGAGGCCTTGGCAGCTGTTTTACGCAAGTACGAAATT
    TTTGTTGTCTGTGATGAGGTTTACTCAGAATTGACCTACACAGGCGAAGCCCATGTGTCT
    CTAGGAACGATGTTGAGAGACCAGGCTATTATTATCAATGGTTTGTCTAAATCGCATGCC
    ATGACAGGTTGGCGTTTGGGGCTGATTTTCGCTCCTGCGGCCTTCACAGCCCAGTTAATC
    AAGAGTCACCAATACTTGGTCACTGCCGCAAATACCATGGCGCAACATGCTGCGGTAGAA
    GCCTTGACGGCTGGTAAAAATGATGCGGAGCCCATGAAGAAGGAATATATCCAGCGTCGG
    GACTATATCATCGAAAAAATGACTGCTCTTGGTTTTGAGATTATCAAACCAGACGGTGCC
    TTCTATATTTTTGCTAAAATTCCAGCGGGCTACAATCAAGACTCCTTTGCTTTTCTGAAG
    GATTTTGCTCAGAAGAAGGCCGTTGCCTTTATCCCTGGTGCAGCCTTTGGACGTTACGGG
    GAATGCTACGTCCGCCTATCTTATGCAGCCAGCATGGAGACTATCAAAGAAGCCATGAAA
    CGACTTGAGGAGTACATGAGAGAAGCATGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1170

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPT_0073 [new locus tag: SPT_RS00370 ]
  • symbol: SPT_0073
  • description: putative aminotransferase A
  • length: 389
  • theoretical pI: 4.90589
  • theoretical MW: 43245.4
  • GRAVY: -0.0732648

⊟Function[edit | edit source]

  • reaction:
    EC 2.6.1.-?  ExPASy
  • TIGRFAM:
    LL-diaminopimelate aminotransferase (TIGR03540; EC 2.6.1.83; HMM-score: 251.4)
    and 20 more
    succinyldiaminopimelate transaminase (TIGR03537; EC 2.6.1.17; HMM-score: 175.5)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 163.3)
    succinyldiaminopimelate transaminase (TIGR03538; EC 2.6.1.17; HMM-score: 142.3)
    succinyldiaminopimelate transaminase (TIGR03539; EC 2.6.1.17; HMM-score: 140.3)
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 134.9)
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 133)
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 128.1)
    Cellular processes Cellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 121.3)
    LL-diaminopimelate aminotransferase (TIGR03542; EC 2.6.1.83; HMM-score: 105.9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin threonine-phosphate decarboxylase (TIGR01140; EC 4.1.1.81; HMM-score: 96.3)
    beta-methylarginine biosynthesis bifunctional aminotransferase (TIGR04544; EC 2.6.-.-; HMM-score: 80.5)
    enduracididine biosynthesis enzyme MppQ (TIGR04461; EC 2.-.-.-; HMM-score: 71.4)
    Metabolism Energy metabolism Amino acids and amines aspartate 4-decarboxylase (TIGR03801; EC 4.1.1.12; HMM-score: 46.1)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides TDP-4-keto-6-deoxy-D-glucose transaminase (TIGR02379; HMM-score: 19.9)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 16.9)
    2-aminoethylphosphonate aminotransferase (TIGR03301; EC 2.6.1.-; HMM-score: 16.5)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Biotin adenosylmethionine-8-amino-7-oxononanoate transaminase (TIGR00508; EC 2.6.1.62; HMM-score: 13.8)
    O-phospho-L-seryl-tRNA:Cys-tRNA synthase (TIGR02539; EC 2.5.1.73; HMM-score: 12.5)
    aminotransferase, LLPSF_NHT_00031 family (TIGR04181; HMM-score: 12.2)
    enduracididine biosynthesis enzyme MppP (TIGR04462; EC 2.-.-.-; HMM-score: 11.4)
  • TheSEED  :
    • Aromatic amino acid aminotransferase gamma (EC 2.6.1.57)
    • N-acetyl-L,L-diaminopimelate aminotransferase (EC 2.6.1.-)
    Amino Acids and Derivatives Aromatic amino acids and derivatives Phenylalanine and Tyrosine Branches from Chorismate  Aromatic amino acid aminotransferase gamma (EC 2.6.1.57)
    and 1 more
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Lysine Biosynthesis DAP Pathway  N-acetyl-L,L-diaminopimelate aminotransferase (EC 2.6.1.-)
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 206.3)
    and 8 more
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 28.2)
    Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 27.9)
    Beta_elim_lyase; Beta-eliminating lyase (PF01212; HMM-score: 19.8)
    Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 17)
    Asp_aminotransf; Aspartate amino-transferase (PF12897; HMM-score: 14.4)
    no clan defined Cas_VVA1548; Putative CRISPR-associated protein (Cas_VVA1548) (PF09652; HMM-score: 12.4)
    NIR_SIR_ferr; Nitrite/Sulfite reductase ferredoxin-like half domain (PF03460; HMM-score: 12.1)
    Ribokinase (CL0118) Phos_pyr_kin; Phosphomethylpyrimidine kinase (PF08543; HMM-score: 12.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9985
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0012
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007828
    • TAT(Tat/SPI): 0.000305
    • LIPO(Sec/SPII): 0.000469
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: ACO22229 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MDLTKRFNKQLDKIQVSLIRQFDQVISEIPGVLRLTLGEPDFTTPDHVKEAAKRAIDQNQSYYTGMSGLLTLRQAASDFVKEKYQLDYAPENEILVTIGATEALSATLTAILEEGDKVLLPAPAYPGYEPIVNLVGAEIVEIDTTENGFVLTPEMLEKAILEQGDKLKAVILNYPANPTGITYSREQLEALAAVLRKYEIFVVCDEVYSELTYTGEAHVSLGTMLRDQAIIINGLSKSHAMTGWRLGLIFAPAAFTAQLIKSHQYLVTAANTMAQHAAVEALTAGKNDAEPMKKEYIQRRDYIIEKMTALGFEIIKPDGAFYIFAKIPAGYNQDSFAFLKDFAQKKAVAFIPGAAFGRYGECYVRLSYAASMETIKEAMKRLEEYMREA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator: RegR* (repression) regulon
    RegR*(TF)important in Hyaluronate utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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