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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 06-SEP-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39V
  • locus tag: SPV_1506 [new locus tag: SPV_RS07995 ]
  • pan locus tag?: PNEUPAN003115000
  • symbol: axe1
  • pan gene symbol?: axe1
  • synonym:
  • product: Bifunctional acetyl xylan esterase 1/cephalosporin-C deacetylase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPV_1506 [new locus tag: SPV_RS07995 ]
  • symbol: axe1
  • product: Bifunctional acetyl xylan esterase 1/cephalosporin-C deacetylase
  • replicon: chromosome
  • strand: -
  • coordinates: 1527404..1528384
  • length: 981
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: CP027540 (1527404..1528384) NCBI
  • BioCyc: SPV_1506 BioCyc
  • MicrobesOnline:
  • PneumoBrowse: SPV_1506 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    ATGAAAAATCCAGCTTTGCTAGAAGAAATTAAGACCTATAGAGGAAGGGATGAGGTTCCG
    GAAGACTTTGATGCTTTCTGGGATGGGGAAGTGAAAAATGTTTCCACGCTTCCATCCTAC
    CACTTGGAGGAAAGAGATTTCCACATTCCTCAAGTCAAGTGCTATGAGTTAACATTTGAA
    GGAAGCAAGGAAGGAAAGGTCTATGCACGCATTGTTCTTCCAAAGAGTGAGGAGAAGGTT
    CCATTAATCTTCCATTTTCATGGTTATATGGGACGTGGCTGGGACTGGGCCGACATGCTG
    GGCTTCACCGTAGCTGGTTACGGTGTTGTTTCCATGGATGTGCGGGGCCAGTCAGGTTAC
    TCACAAGACGGCTTGCGTTCTCCTTTAGGAAATACCGTGAAGGGGCATATTATCCGTGGT
    GCTGTGGAAGGTCGGGACCACCTCTTTTATAAGGATGTTTATCTGGATATTTACCAGTTG
    GTCGAAATTGTTGCTAGTCTGTCTCAGGTTGATGAGAAGCGTCTTTCTAGCTATGGTGCC
    TCACAAGGAGGGGCTCTAGCCCTAGTTGCAGCAGCGCTCAATCCTCGAATTCAGAAAACA
    GTTGCCATTTATCCCTTCTTGTCAGACTTCAGACGGGTGATTGAGATTGGTAATACTAGC
    GAGGCTTACGACGAACTTTTCCGTTATTTCAAGTTTTACGACCCCTTCCATGAAACAGAG
    GAGGAAATCATGGCGACCCTTGCCTATATCGATGTCAAAAATCTTGCCCATCGTATCCAA
    GGTGAGGTTAAGATGATTACGGGCTTGGACGACGATGTTTGCTATCCCATTACCCAGTTT
    GCGATTTATAATCGTCTGACCTGCGATAAAACCTATCGTATCATGCCTGAGTATGCTCAC
    GAAGCCATGAATGTATTTGTTAATGACCAAGTCTACAACTGGCTCTGTGGAAGTGAGATT
    CCTTTTAAATATCTAAAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    981

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPV_1506 [new locus tag: SPV_RS07995 ]
  • symbol: Axe1
  • description: Bifunctional acetyl xylan esterase 1/cephalosporin-C deacetylase
  • length: 326
  • theoretical pI: 5.02903
  • theoretical MW: 37439.3
  • GRAVY: -0.274233

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.1.41?  ExPASy
    Cephalosporin-C deacetylase Cephalosporin C + H2O = deacetylcephalosporin C + acetate
  • TIGRFAM:
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit (TIGR01836; HMM-score: 16.8)
    Unknown function Enzymes of unknown specificity hydrolase CocE/NonD family protein (TIGR00976; HMM-score: 16.6)
    and 2 more
    Cellular processes Cellular processes Detoxification S-formylglutathione hydrolase (TIGR02821; EC 3.1.2.12; HMM-score: 12.5)
    Metabolism Energy metabolism Photosynthesis putative magnesium chelatase accessory protein (TIGR03056; HMM-score: 12)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    AB_hydrolase (CL0028) AXE1; Acetyl xylan esterase (AXE1) (PF05448; HMM-score: 470.7)
    and 10 more
    Peptidase_S9; Prolyl oligopeptidase family (PF00326; HMM-score: 36.5)
    Hydrolase_4; Serine aminopeptidase, S33 (PF12146; HMM-score: 33.6)
    Peptidase_S15; X-Pro dipeptidyl-peptidase (S15 family) (PF02129; HMM-score: 26.5)
    DLH; Dienelactone hydrolase family (PF01738; HMM-score: 21.4)
    Abhydrolase_6; Alpha/beta hydrolase family (PF12697; HMM-score: 21.1)
    Abhydrolase_1; alpha/beta hydrolase fold (PF00561; HMM-score: 20.3)
    Abhydrolase_3; alpha/beta hydrolase fold (PF07859; HMM-score: 13.1)
    Esterase; Putative esterase (PF00756; HMM-score: 13)
    BAAT_C; BAAT / Acyl-CoA thioester hydrolase C terminal (PF08840; HMM-score: 12.1)
    PhoPQ_related; PhoPQ-activated pathogenicity-related protein (PF10142; HMM-score: 11.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9544
    • Cytoplasmic Membrane Score: 0.0139
    • Cell wall & surface Score: 0.0007
    • Extracellular Score: 0.031
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.006518
    • TAT(Tat/SPI): 0.000921
    • LIPO(Sec/SPII): 0.001063
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: AVN86582 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKNPALLEEIKTYRGRDEVPEDFDAFWDGEVKNVSTLPSYHLEERDFHIPQVKCYELTFEGSKEGKVYARIVLPKSEEKVPLIFHFHGYMGRGWDWADMLGFTVAGYGVVSMDVRGQSGYSQDGLRSPLGNTVKGHIIRGAVEGRDHLFYKDVYLDIYQLVEIVASLSQVDEKRLSSYGASQGGALALVAAALNPRIQKTVAIYPFLSDFRRVIEIGNTSEAYDELFRYFKFYDPFHETEEEIMATLAYIDVKNLAHRIQGEVKMITGLDDDVCYPITQFAIYNRLTCDKTYRIMPEYAHEAMNVFVNDQVYNWLCGSEIPFKYLK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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