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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0575 [new locus tag: SP_RS13750 ]
  • pan locus tag?: PNEUPAN000276000
  • symbol: SP_0575
  • pan gene symbol?: uvrB_1
  • synonym:
  • product: putative helicase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0575 [new locus tag: SP_RS13750 ]
  • symbol: SP_0575
  • product: putative helicase
  • replicon: chromosome
  • strand: +
  • coordinates: 541218..542864
  • length: 1647
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: AE005672 (541218..542864) NCBI
  • BioCyc:
  • MicrobesOnline: 116088 MicrobesOnline
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGTATTTATTTGGAGAATCCGATCATTATTTATGGTTGCCAAGAGGTTTGCTGTATCCA
    TTGCAAGATAAATTTAAGCAGGTATCTGTGGAAGATAGGAGAAAGGTACAAAGGTCTATT
    AGCGTGGAATTTAAGGGAGAACTCACTTTTGAGCAAGAGTTAGCCCTGTCAGATATGACT
    TCTAAAGAAAATGGTTTACTTCATGCGGAGACTGGTTTTGGGAAGACCGTTTTAGGTGCT
    GCTCTTATCTCTGAACGGAAAACAAAAACAATTATTCTAGTCCATAATAAGCAACTCTTA
    GACCAATGGCTAGATCGCTTAAACTGCTTTTTGACTTTCGAAGAGGAGGAGGCTATCCGT
    TATACGGCATCAGGTCGTGAAAAGGTAATCGGCTATGTTGGGCAGTACGGTGGGACTAAG
    AAATGGCTGAGTAAACTGGTTGATGTCGTTATGATTCAATCTCTATTTAAGTTGGAAAAT
    AGTCAAAGTCTTTTGGATGAGTATGAGATGATGATTGTGGATGAGTGTCATCATGTCTCT
    GCCTTGATGTTTGAAAAAGTTGTTGCTCAGTTTAGAGGGAAGTATCTTTACGGTTTGACG
    GCTACGCCTGAGCGTAAGAATGGTCATGAGCCTATTGTTTTTCAGAGAATTGGTGAGATA
    CTCCATACTGCTGATAAGAGGGAAACGGATTTTAAACGGCAATTGCAATTAAGATTCACT
    TCTTTTGGTCATTTGGAAATTGAAAAGACCAAAGCAAGTAATTTTATACAGCTTAGTGAT
    TGGATTGCTACTGACTCAGTGAGGAATCAGATGATTCTCAAGGATATTCTAGCCCAAGTG
    GCAGAAGGACGGAATATCTTGGTTTTAGTTAATCGAATTCAACAGATAGATGTCTTTGAA
    AAATTATTGAAAGAGAAAGAGGTTGATGACTGTTACATTATTAGCGGAAAAACCAAAGTC
    CGAGAGAGAACGAGTTTACTGGAGACGTTAGAACAGTTAGATAAAGGGTTTGTTTTGTTG
    TCTACTGGAAAATACATTGGCGAAGGTTTTGACTTACCTCAGTTGGACACGCTTATCTTG
    GCAGCACCCTTTTCTTGGAAAAATAATTTGATTCAGTATGCAGGTCGGATTCATAGAAAC
    TACAAGGATAAGTCTTTGGTGCGTATTTTCGATTATGTGGATATTCATGTTCCTTATTTA
    GAAAAGATGTTTCAGAAACGACAAGTAGCTTATCGAAAGATGGATTATCGTGTCATCGAG
    GGTGAGGAGAAACAATTCGTTTATGTTGATAGTAGATATGAGAAGGTGTTGAGAGAGGAC
    TTAGCAGGGGAAAGACAGGAATGTCTGCTTATTTTACCTTATGTGCACCAGACAAAACTG
    ATGAATTTTCTAAAAGAATTTAGGATTAGTCAAATTGAGATATGTATACCAGAGACGGTT
    GCAAATAAAGCATGGCTAGACCAGTTGAAGAGCCAGAAAATTAAAGTGTCTTTTACTCAA
    TCAAAAATAGTAACGCCTATTCTTTTGGTGAATAAGACTATTGTTTGGTATGGTGCAATG
    CCATTATTAGGGAAGGTAGATGAGATGACCATATTACGTTTGGAATCAGCTAGTATAGTT
    TCTGAACTAGTGGCAGGTTTACGATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1647

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0575 [new locus tag: SP_RS13750 ]
  • symbol: SP_0575
  • description: putative helicase
  • length: 548
  • theoretical pI: 8.17429
  • theoretical MW: 63666.4
  • GRAVY: -0.221533

⊟Function[edit | edit source]

  • TIGRFAM:
    DNA phosphorothioation system restriction enzyme (TIGR04095; HMM-score: 58.7)
    and 3 more
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA repair helicase rad25 (TIGR00603; EC 3.6.4.12; HMM-score: 39.2)
    CRISPR-associated helicase Cas3 (TIGR01587; HMM-score: 28)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair excinuclease ABC subunit B (TIGR00631; EC 3.1.25.-; HMM-score: 24.3)
  • TheSEED  :
    • DNA/RNA HELICASE (DEAD/DEAH BOX FAMILY)
  • PFAM:
    P-loop_NTPase (CL0023) ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 78.6)
    and 7 more
    Helicase_C; Helicase conserved C-terminal domain (PF00271; HMM-score: 44.1)
    DEAD; DEAD/DEAH box helicase (PF00270; HMM-score: 32.8)
    SNF2-rel_dom; SNF2-related domain (PF00176; HMM-score: 30.5)
    iSTAND; inactive STAND (PF19995; HMM-score: 17.6)
    AAA_22; AAA domain (PF13401; HMM-score: 15.9)
    Helicase_C_2; Helicase C-terminal domain (PF13307; HMM-score: 15.3)
    Ferritin (CL0044) AurF; P-aminobenzoate N-oxygenase AurF (PF11583; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8367
    • Cytoplasmic Membrane Score: 0.1509
    • Cell wall & surface Score: 0.0075
    • Extracellular Score: 0.0049
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002029
    • TAT(Tat/SPI): 0.000171
    • LIPO(Sec/SPII): 0.000524
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MYLFGESDHYLWLPRGLLYPLQDKFKQVSVEDRRKVQRSISVEFKGELTFEQELALSDMTSKENGLLHAETGFGKTVLGAALISERKTKTIILVHNKQLLDQWLDRLNCFLTFEEEEAIRYTASGREKVIGYVGQYGGTKKWLSKLVDVVMIQSLFKLENSQSLLDEYEMMIVDECHHVSALMFEKVVAQFRGKYLYGLTATPERKNGHEPIVFQRIGEILHTADKRETDFKRQLQLRFTSFGHLEIEKTKASNFIQLSDWIATDSVRNQMILKDILAQVAEGRNILVLVNRIQQIDVFEKLLKEKEVDDCYIISGKTKVRERTSLLETLEQLDKGFVLLSTGKYIGEGFDLPQLDTLILAAPFSWKNNLIQYAGRIHRNYKDKSLVRIFDYVDIHVPYLEKMFQKRQVAYRKMDYRVIEGEEKQFVYVDSRYEKVLREDLAGERQECLLILPYVHQTKLMNFLKEFRISQIEICIPETVANKAWLDQLKSQKIKVSFTQSKIVTPILLVNKTIVWYGAMPLLGKVDEMTILRLESASIVSELVAGLR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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