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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0611 [new locus tag: SP_RS03005 ]
  • pan locus tag?: PNEUPAN001506000
  • symbol: recJ
  • pan gene symbol?: recJ
  • synonym:
  • product: single-stranded-DNA-specific exonuclease RecJ

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0611 [new locus tag: SP_RS03005 ]
  • symbol: recJ
  • product: single-stranded-DNA-specific exonuclease RecJ
  • replicon: chromosome
  • strand: +
  • coordinates: 577452..579674
  • length: 2223
  • essential: yes [1]

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    TTGATAACACCTACTTATGAATGGCAGTTTGCCCTGCAGGTAGAAGATGCGGATTTTACA
    AAGATAGCCAAGAAGGCTGGACTGGGTCCTGAGGTGGCTCGGTTATTGTTTGAGAGAGGG
    ATTCAGAACCAAGAAAGTCTGAAGAAGTTTTTAGAACCTTCCTTGGAGGACTTACATGAT
    GCTTATCTGCTCCATGATATGGACAAGGCAGTGGAGCGGATTCGTCAGGCTATTGAAGAA
    GGGGAAAATATTCTTGTTTATGGAGACTATGATGCGGATGGCATGACTTCGGCTTCTATT
    GTGAAGGAAAGTTTGGAACAACTTGGTGCTGAGTGCCGAGTTTACCTGCCAAATCGTTTT
    ACCGATGGCTATGGCCCTAATGCTAGTGTTTATAAATACTTTATCGAGCAAGAAGGGATT
    TCCTTGATTGTGACGGTGGACAATGGGGTTGCTGGTCATGAGGCTATTGCATTGGCTCAG
    TCTATGGGAGTAGATGTCATTGTGACAGACCATCATTCCATGCCTGAAACCCTGCCAGAT
    GCTTATGCTATTGTCCATCCTGAACATCCAGATGCGGATTATCCTTTTAAATATTTGGCT
    GGTTGTGGAGTTGCTTTCAAGTTGGCTTGTGCCCTGTTAGAAGAAGTGCAAGTGGAATTG
    CTTGATTTGGTCGCTATTGGAACTATTGCAGATATGGTGAGTCTGACGGATGAAAATCGT
    ATCTTAGTTCAATATGGTCTGGAAATGTTGGGTCATACCCAGCGCATTGGTCTGCAAGAA
    ATGCTGGACATGGCTGGGATTGCTGCCAACGAAGTAACAGAAGAAACGGTTGGTTTCCAG
    ATTGCTCCTCGTTTGAATGCCTTGGGTCGCTTGGATGATCCCAATCCTGCCATTGATTTG
    TTGACTGGATTTGATGATGAGGAAGCGCATGAGATTGCCCTTATGATTCACCAGAAAAAC
    GAAGAGCGCAAGGAAATCGTTCAGTCTATCTATGAAGAAGCCAAGACCATGGTGGATCCT
    GAGAAGAAGGTTCAGGTCTTGGCCAAGGAAGGCTGGAATCCTGGGGTTCTAGGAATCGTG
    GCTGGTCGTTTATTGGAAGAATTGGGACAGACAGTCATTGTTCTTAATATAGAAGACGGT
    CGTGCCAAGGGCAGTGCTCGTAGTGTGGAAGCGGTCGATATTTTTGAAGCTCTGGATCCC
    CATCGAGACCTCTTCATCGCCTTTGGAGGTCATGCAGGTGCAGCGGGTATGACGCTGGAA
    GTTGAGCAACTCTCAGATTTATCTCAGGTTTTGGAAGATTATGTTCGTGAAAAAGGTGCA
    GATGCTGGTGGCAAGAATAAGTTAAACCTAGATGAAGAGTTGGATTTGGAGGCACTTAGC
    TTGGAAACGGTCAAAAGTTTTGAACGTTTAGCTCCTTTTGGAATGGATAATCAGAAACCT
    ATTTTTTATATCAAGAATTTTCAGGTCGAAAGTGCTCGTACTATGGGGGCAGGTAATGCC
    CATCTAAAGCTGAAAATTTCCAAGGGTGAGGCGAGTTTTGAAGTGGTAGCCTTTGGTCAA
    GGCAGATGGGCGACAGAGTTTTCTCAAACCAAGAATCTAGAGTTAGCGGTTAAATTGTCT
    GTCAACCAATGGAATGGCCAAACTGCCCTCCAGTTGATGATGGTGGATGCGCGAGTGGAA
    GGTGTTCAACTTTTTAACATTCGTGGAAAAAATGCAGTCTTGCCAGAAGGTGTTCCAGTC
    TTGGATTTTCCTGGAGAACTGCCAAATCTTGCGGCTAGTGAAGCTGTTGTCGTAAAAAAC
    ATTCCAGAGGATATTACTCAGCTGAAGACCATTTTTCAGGAACAGCATTTCTCTGCTGTC
    TATTTCAAAAATGATATTGACAAGGCTTATTATCTGACAGGTTATGGGACTAGAGATCAG
    TTTGCCAAATTGTACAAGACTATTTACCAGTTCCCAGAGTTTGATATTCGCTACAAGCTG
    AAAGATTTGGCTGCATATCTTAATATTCAACAAATCTTGCTGGTCAAGATGATTCAAGTA
    TTTGAAGAACTAGGCTTTGTGACGATAAAAGATGGTGTGATGACAGTCAATAAAGAGGCG
    CCAAAGCGGGAGATAGGAGAAAGTCAAATTTACCAAAATCTCAAACAAACCGTTAAAGAC
    CAAGAAATGATGGCGCTGGGTACGGTGCAAGAAATTTATGATTTTTTGATGGAAAAAGAG
    TAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2223

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0611 [new locus tag: SP_RS03005 ]
  • symbol: RecJ
  • description: single-stranded-DNA-specific exonuclease RecJ
  • length: 740
  • theoretical pI: 4.36059
  • theoretical MW: 82479.4
  • GRAVY: -0.154595

⊟Function[edit | edit source]

  • reaction:
    EC 3.1.-.-?  ExPASy
  • TIGRFAM:
    Genetic information processing DNA metabolism DNA replication, recombination, and repair single-stranded-DNA-specific exonuclease RecJ (TIGR00644; EC 3.1.-.-; HMM-score: 601.1)
  • TheSEED  :
    • Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-)
    DNA Metabolism DNA repair DNA Repair Base Excision  Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-)
    and 2 more
    DNA Metabolism DNA repair DNA repair, bacterial RecFOR pathway  Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-)
    DNA Metabolism DNA replication DNA-replication  Single-stranded-DNA-specific exonuclease RecJ (EC 3.1.-.-)
  • PFAM:
    no clan defined ssDNA-exonuc_C; Single-strand DNA-specific exonuclease, C terminal domain (PF10141; HMM-score: 118.7)
    OB (CL0021) RecJ_OB; RecJ OB domain (PF17768; HMM-score: 98.4)
    and 8 more
    HAD (CL0137) DHH; DHH family (PF01368; HMM-score: 79.1)
    no clan defined DHHA1; DHHA1 domain (PF02272; HMM-score: 69.8)
    NADP_Rossmann (CL0063) YjeF_N; YjeF-related protein N-terminus (PF03853; HMM-score: 15.1)
    no clan defined PGM_PMM_II; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II (PF02879; HMM-score: 14.4)
    NADP_Rossmann (CL0063) AlaDh_PNT_C; Alanine dehydrogenase/PNT, C-terminal domain (PF01262; HMM-score: 14.1)
    Phosphatase (CL0031) DSPc; Dual specificity phosphatase, catalytic domain (PF00782; HMM-score: 13.5)
    TIM_barrel (CL0036) ThiG; Thiazole biosynthesis protein ThiG (PF05690; HMM-score: 12.8)
    GT-B (CL0113) PIGA; PIGA (GPI anchor biosynthesis) (PF08288; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9946
    • Cytoplasmic Membrane Score: 0.0023
    • Cell wall & surface Score: 0.0021
    • Extracellular Score: 0.0009
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002142
    • TAT(Tat/SPI): 0.000178
    • LIPO(Sec/SPII): 0.00037
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MITPTYEWQFALQVEDADFTKIAKKAGLGPEVARLLFERGIQNQESLKKFLEPSLEDLHDAYLLHDMDKAVERIRQAIEEGENILVYGDYDADGMTSASIVKESLEQLGAECRVYLPNRFTDGYGPNASVYKYFIEQEGISLIVTVDNGVAGHEAIALAQSMGVDVIVTDHHSMPETLPDAYAIVHPEHPDADYPFKYLAGCGVAFKLACALLEEVQVELLDLVAIGTIADMVSLTDENRILVQYGLEMLGHTQRIGLQEMLDMAGIAANEVTEETVGFQIAPRLNALGRLDDPNPAIDLLTGFDDEEAHEIALMIHQKNEERKEIVQSIYEEAKTMVDPEKKVQVLAKEGWNPGVLGIVAGRLLEELGQTVIVLNIEDGRAKGSARSVEAVDIFEALDPHRDLFIAFGGHAGAAGMTLEVEQLSDLSQVLEDYVREKGADAGGKNKLNLDEELDLEALSLETVKSFERLAPFGMDNQKPIFYIKNFQVESARTMGAGNAHLKLKISKGEASFEVVAFGQGRWATEFSQTKNLELAVKLSVNQWNGQTALQLMMVDARVEGVQLFNIRGKNAVLPEGVPVLDFPGELPNLAASEAVVVKNIPEDITQLKTIFQEQHFSAVYFKNDIDKAYYLTGYGTRDQFAKLYKTIYQFPEFDIRYKLKDLAAYLNIQQILLVKMIQVFEELGFVTIKDGVMTVNKEAPKREIGESQIYQNLKQTVKDQEMMALGTVQEIYDFLMEKE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site: 577422 [2]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)
  2. ↑ 2.0 2.1 2.2 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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