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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0614 [new locus tag: SP_RS03015 ]
  • pan locus tag?: PNEUPAN001508000
  • symbol: estA
  • pan gene symbol?: estA
  • synonym:
  • product: tributyrin esterase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0614 [new locus tag: SP_RS03015 ]
  • symbol: estA
  • product: tributyrin esterase
  • replicon: chromosome
  • strand: +
  • coordinates: 581579..582358
  • length: 780
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    ATGGCAGTGATGAAAATCGAGTATTACTCACAAGTATTGGATATGGAGTGGGGGGTGAAT
    GTCCTCTACCCTGATGCCAATCGAGTGGAAGAACCAGAGTGTGAAGATATTCCCGTCTTG
    TACCTTTTGCACGGGATGTCTGGAAATCATAATAGTTGGCTTAAGCGGACCAATGTAGAA
    CGCTTGCTTCGAGGAACTAATCTCATCGTTGTTATGCCCAATACCAGCAATGGTTGGTAC
    ACCGATACCCAGTATGGTTTTGACTACTACACGGCTCTAGCAGAGGAATTGCCACAGGTT
    CTGAAACGCTTCTTCCCTAATATGACGAGCAAGCGTGAAAAGACCTTTATCGCTGGTCTT
    TCTATGGGAGGCTACGGCTGCTTCAAACTGGCTCTTACGACAAATCGTTTTTCTCATGCA
    GCTAGTTTTTCAGGTGCCCTCAGCTTTCAAAACTTTTCTCCTGAAAGTCAAAATCTGGGA
    AGTCCAGCCTACTGGAGAGGTGTTTTTGGAGAGATTAGAGACTGGACAACTAGTCCCTAT
    TCTCTTGAAAGTCTGGCTAAAAAATCGGATAAAAAGACCAAACTTTGGGCGTGGTGTGGC
    GAACAGGATTTCTTGTACGAAGCCAATAATCTCGCAGTGAAAAATCTCAAAAAACTAGGT
    TTTGATGTGACCTATAGCCATAGCGCTGGAACTCACGAGTGGTACTACTGGGAAAAACAA
    TTGGAAGTTTTTTTAACAACCCTACCAATTGATTTCAAATTAGAAGAGAGACTGACTTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0614 [new locus tag: SP_RS03015 ]
  • symbol: EstA
  • description: tributyrin esterase
  • length: 259
  • theoretical pI: 6.04014
  • theoretical MW: 29899.7
  • GRAVY: -0.388417

⊟Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Detoxification S-formylglutathione hydrolase (TIGR02821; EC 3.1.2.12; HMM-score: 39.2)
    and 2 more
    Metabolism Fatty acid and phospholipid metabolism Degradation esterase, PHB depolymerase family (TIGR01840; EC 3.1.1.-; HMM-score: 17.3)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Menaquinone and ubiquinone 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (TIGR03695; EC 4.2.99.20; HMM-score: 14)
  • TheSEED  :
    • Esterase/lipase
  • PFAM:
    AB_hydrolase (CL0028) Esterase; Putative esterase (PF00756; HMM-score: 71.4)
    and 6 more
    Chlorophyllase2; Chlorophyllase enzyme (PF12740; HMM-score: 21.4)
    Chlorophyllase; Chlorophyllase (PF07224; HMM-score: 20.9)
    Abhydrolase_2; Phospholipase/Carboxylesterase (PF02230; HMM-score: 17.5)
    Abhydrolase_6; Alpha/beta hydrolase family (PF12697; HMM-score: 16.5)
    Abhydrolase_1; alpha/beta hydrolase fold (PF00561; HMM-score: 16.4)
    Hydrolase_4; Serine aminopeptidase, S33 (PF12146; HMM-score: 11.2)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8817
    • Cytoplasmic Membrane Score: 0.009
    • Cell wall & surface Score: 0.0009
    • Extracellular Score: 0.1084
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004623
    • TAT(Tat/SPI): 0.000253
    • LIPO(Sec/SPII): 0.000477
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MAVMKIEYYSQVLDMEWGVNVLYPDANRVEEPECEDIPVLYLLHGMSGNHNSWLKRTNVERLLRGTNLIVVMPNTSNGWYTDTQYGFDYYTALAEELPQVLKRFFPNMTSKREKTFIAGLSMGGYGCFKLALTTNRFSHAASFSGALSFQNFSPESQNLGSPAYWRGVFGEIRDWTTSPYSLESLAKKSDKKTKLWAWCGEQDFLYEANNLAVKNLKKLGFDVTYSHSAGTHEWYYWEKQLEVFLTTLPIDFKLEERLT

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site: 581279 [1]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 1.2 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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