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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_0944 [new locus tag: SP_RS04670 ]
- pan locus tag?: PNEUPAN001932000
- symbol: pyrH
- pan gene symbol?: pyrH
- synonym:
- product: uridylate kinase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_0944 [new locus tag: SP_RS04670 ]
- symbol: pyrH
- product: uridylate kinase
- replicon: chromosome
- strand: +
- coordinates: 894372..895115
- length: 744
- essential: yes [1] other strains
⊟Accession numbers[edit | edit source]
- Location: AE005672 (894372..895115) NCBI
- BioCyc:
- MicrobesOnline: 116426 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_0834 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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721GTGAAAATGGCGAATCCCAAGTATAAACGTATTTTAATCAAGTTATCAGGTGAAGCCCTT
GCCGGTGAACGTGGCGTAGGGATTGATATCCAAACAGTTCAAACAATCGCAAAAGAGATT
CAAGAAGTTCATAGCTTAGGTATCGAAATTGCCCTTGTTATCGGTGGAGGAAATCTCTGG
CGTGGAGAACCTGCAGCAGAAGCAGGTATGGACCGTGTTCAGGCAGATTACACAGGAATG
CTTGGGACTGTTATGAATGCTCTTGTGATGGCAGATTCATTGCAACAAGTTGGGGTTGAT
ACGCGTGTACAAACAGCTATTGCCATGCAACAAGTGGCAGAGCCTTATGTCCGTGGACGT
GCCCTTCGTCACCTTGAAAAAGGCCGTATCGTTATCTTTGGTGCTGGAATTGGTTCACCT
TACTTCTCGACAGATACAACAGCGGCCCTTCGTGCAGCTGAAATCGAAGCAGATGCCATC
CTCATGGCTAAAAATGGTGTCGATGGTGTTTACAATGCCGATCCTAAGAAAGATAAGACA
GCTGTTAAGTTTGAAGAATTGACCCACCGTGACGTTATCAATAAAGGTCTTCGTATCATG
GACTCAACAGCTTCAACCCTCTCAATGGACAACGACATTGACTTGGTTGTATTCAACATG
AACCAACCAGGCAACATCAAACGTGTCGTATTTGGTGAAAATATCGGAACAACAGTTTCA
AATAATATCGAAGAAAAGGAATAA60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_0944 [new locus tag: SP_RS04670 ]
- symbol: PyrH
- description: uridylate kinase
- length: 247
- theoretical pI: 5.16783
- theoretical MW: 26702.4
- GRAVY: -0.106478
⊟Function[edit | edit source]
- reaction: EC 2.7.4.-? ExPASy
- TIGRFAM: Purines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions UMP kinase (TIGR02075; EC 2.7.4.22; HMM-score: 324)and 4 morePurines, pyrimidines, nucleosides, and nucleotides Nucleotide and nucleoside interconversions putative uridylate kinase (TIGR02076; EC 2.7.4.-; HMM-score: 93.8)Amino acid biosynthesis Glutamate family glutamate 5-kinase (TIGR01027; EC 2.7.2.11; HMM-score: 31.1)Amino acid biosynthesis Aspartate family aspartate kinase, monofunctional class (TIGR00656; EC 2.7.2.4; HMM-score: 30)Amino acid biosynthesis Aspartate family aspartate kinase (TIGR00657; EC 2.7.2.4; HMM-score: 29)
- TheSEED :
- Uridylate kinase (EC 2.7.4.22)
- PFAM: no clan defined AA_kinase; Amino acid kinase family (PF00696; HMM-score: 95.6)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 7.5
- Cytoplasmic Membrane Score: 1.15
- Cellwall Score: 0.62
- Extracellular Score: 0.73
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9559
- Cytoplasmic Membrane Score: 0.0196
- Cell wall & surface Score: 0.0001
- Extracellular Score: 0.0244
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.008583
- TAT(Tat/SPI): 0.000283
- LIPO(Sec/SPII): 0.000957
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MKMANPKYKRILIKLSGEALAGERGVGIDIQTVQTIAKEIQEVHSLGIEIALVIGGGNLWRGEPAAEAGMDRVQADYTGMLGTVMNALVMADSLQQVGVDTRVQTAIAMQQVAEPYVRGRALRHLEKGRIVIFGAGIGSPYFSTDTTAALRAAEIEADAILMAKNGVDGVYNADPKKDKTAVKFEELTHRDVINKGLRIMDSTASTLSMDNDIDLVVFNMNQPGNIKRVVFGENIGTTVSNNIEEKE
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: pyrH > frr > SP_0946 > SP_0947
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site: 894357 [2]
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0834 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Tim van Opijnen, Andrew Camilli
A fine scale phenotype-genotype virulence map of a bacterial pathogen.
Genome Res: 2012, 22(12);2541-51
[PubMed:22826510] [WorldCat.org] [DOI] (I p) - ↑ 2.0 2.1 2.2 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
PLoS Pathog: 2018, 14(12);e1007461
[PubMed:30517198] [WorldCat.org] [DOI] (I e)