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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 31-JAN-2014
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae TIGR4
- locus tag: SP_0945 [new locus tag: SP_RS04675 ]
- pan locus tag?: PNEUPAN001933000
- symbol: frr
- pan gene symbol?: frr
- synonym:
- product: ribosome recycling factor
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: SP_0945 [new locus tag: SP_RS04675 ]
- symbol: frr
- product: ribosome recycling factor
- replicon: chromosome
- strand: +
- coordinates: 895124..895681
- length: 558
- essential: yes [1] DEG
⊟Accession numbers[edit | edit source]
- Location: AE005672 (895124..895681) NCBI
- BioCyc:
- MicrobesOnline: 116427 MicrobesOnline
- PneumoBrowse for strain D39V: SPV_0835 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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481
541ATGGCTAACGCAATTATTGAAAAAGCTAAAGAGAGAATGACCCAGTCTCACCAATCACTT
GCTCGTGAATTTGGTGGTATCCGTGCTGGTCGTGCCAATGCAAGCTTGCTTGACCGTGTA
CATGTAGAATACTATGGAGTCGAAACTCCTCTTAACCAAATCGCTTCAATTACGATTCCA
GAAGCGCGTGTTTTGTTGGTAACACCATTTGACAAGTCTTCATTGAAAGACATCGAACGT
GCCTTGAACGCTTCTGATATTGGTATCACACCGGCTAATGACGGTTCTGTGATTCGCTTG
GTTATCCCAGCTCTTACAGAAGAAACTCGTCGTGACCTTGCTAAAGAAGTGAAGAAGGTC
GGCGAAAATGCTAAAGTGGCTGTCCGCAATATCCGTCGCGATGCTATGGACGAAGCTAAG
AAACGAGAAAAAGCAAAAGAAATCACTGAAGACGAATTGAAGACTCTTGAAAAAGACATT
CAAAAAGTAACAGACGATGCTGTTAAACACATCGACGACATGACTGCTAACAAAGAGAAA
GAACTTTTGGAAGTCTAA60
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558
⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SP_0945 [new locus tag: SP_RS04675 ]
- symbol: Frr
- description: ribosome recycling factor
- length: 185
- theoretical pI: 6.30793
- theoretical MW: 20656.5
- GRAVY: -0.524324
⊟Function[edit | edit source]
- TIGRFAM: Protein synthesis Translation factors ribosome recycling factor (TIGR00496; HMM-score: 231.4)and 1 moreEnergy metabolism Pyruvate dehydrogenase pyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit (TIGR03182; EC 1.2.4.1; HMM-score: 9.3)
- TheSEED :
- Ribosome recycling factor
- PFAM: no clan defined RRF; Ribosome recycling factor (PF01765; HMM-score: 208.3)and 7 moreTPR (CL0020) 14-3-3; 14-3-3 protein (PF00244; HMM-score: 19.7)no clan defined DUF6076; Family of unknown function (DUF6076) (PF19553; HMM-score: 16.1)EspB; Enterobacterial EspB protein (PF05802; HMM-score: 15.4)YtxH; YtxH-like protein (PF12732; HMM-score: 14)Enkurin; Calmodulin-binding (PF13864; HMM-score: 11.4)DUF2390; Protein of unknown function (DUF2390) (PF09523; HMM-score: 11.2)Phage_holin_6_1; Bacteriophage holin of superfamily 6 (Holin_LLH) (PF09682; HMM-score: 10.9)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cytoplasmic
- Cytoplasmic Score: 9.97
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 0.01
- Extracellular Score: 0.02
- Internal Helices: 0
- DeepLocPro: Cytoplasmic
- Cytoplasmic Score: 0.9968
- Cytoplasmic Membrane Score: 0.0002
- Cell wall & surface Score: 0
- Extracellular Score: 0.003
- SignalP: no predicted signal peptide
- SP(Sec/SPI): 0.004637
- TAT(Tat/SPI): 0.006705
- LIPO(Sec/SPII): 0.000753
- predicted transmembrane helices (TMHMM): 0
⊟Accession numbers[edit | edit source]
⊟Protein sequence[edit | edit source]
- MANAIIEKAKERMTQSHQSLAREFGGIRAGRANASLLDRVHVEYYGVETPLNQIASITIPEARVLLVTPFDKSSLKDIERALNASDIGITPANDGSVIRLVIPALTEETRRDLAKEVKKVGENAKVAVRNIRRDAMDEAKKREKAKEITEDELKTLEKDIQKVTDDAVKHIDDMTANKEKELLEV
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
- MicrobesOnline: pyrH > frr > SP_0946 > SP_0947
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site: 894948 [2]
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0835 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
- ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
Nucleic Acids Res: 2002, 30(14);3152-62
[PubMed:12136097] [WorldCat.org] [DOI] (I p)Tim van Opijnen, Andrew Camilli
A fine scale phenotype-genotype virulence map of a bacterial pathogen.
Genome Res: 2012, 22(12);2541-51
[PubMed:22826510] [WorldCat.org] [DOI] (I p) - ↑ 2.0 2.1 2.2 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
PLoS Pathog: 2018, 14(12);e1007461
[PubMed:30517198] [WorldCat.org] [DOI] (I e)