PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 11-DEC-2024

⊟Summary

• organism: Streptococcus pneumoniae A026
• locus tag: T308_RS01865 [old locus tag: T308_01870 ]
• pan locus tag^?: PNEUPAN001212000
• symbol: cbpC
• pan gene symbol^?: cbpF
• synonym: cbpJ
• product: choline-binding protein CbpC

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: T308_RS01865 [old locus tag: T308_01870 ]
• symbol: cbpC
• product: choline-binding protein CbpC
• replicon: chromosome
• strand: +
• coordinates: 349834..350796
• length: 963
• essential: unknown

⊟Accession numbers

• Location: NC_022655 (349834..350796) NCBI
• BioCyc: T308_RS01865 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0345 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  481
  541
  601
  661
  721
  781
  841
  901
  961
  
  ATGAAAATTTTGAAAAAAATGATGCAAGTTCTACTAGCAGTCTTTTTCTTTGGTTTGCTA
  GCTACAAATACGGTATTTGCGAATACCACAGGTGGCCGATTTGTTGATAAGGATAATAGA
  AAATATTATGTAAAAGATGATCATAAAGCAATCTATTGGCATAAAATAGACGGTAAAACC
  TACTATTTTGGTGATGGAGGAGAGATGGTTGTCGGTTGGCAATACTTAGAAATTCCTGGA
  ACAGGTTATCGTGATAATTTATTCGATAACCAACCAGTTAATGAAATTGGCCTTCAGGAG
  AAGTGGTACTATTTTGGACAAGATGGTGCTTTGTTAGAACAAACAGATAAACAAGTACTA
  GAGGCAAAAACGTCTGAAAATACAGGAAAAGTATACGGTGAACAATATCCTCTATCTGCT
  GAAAAGAGAACTTATTATTTTGATAATAATTATGTTGTAAAGACAGGCTGGATTTATGAA
  GACGGCAATTGGTATTATTTAAATAAGCTAGGAAATTTTGGCGATGATTCTTACAATCCA
  CTACCAATTGGTGAAGTTGCTAAGGGTTGGACTCAAGATTTTCATGTTACTATTGACATT
  GATAGAAGCAAACCTGCTCCATGGTACTACCTAGATGCTTCCGGTAAGATGCTTACAGAT
  TGGCAAAAAGTAAACGGAAAATGGTATTATTTTGGCTCCTCTGGTTCTATGGCAACAGGT
  TGGAAATATGTACGAGGCAAATGGTATTACTTAGATAATAAAAATGGTGATATGAAGACT
  GGTTGGTATCAAGATGGTTCAACTTGGTACTATTTAGATCCTTCTAATGGAGATATGAAA
  ATAGGTTGGACAAAAGTAAATGGAAAATGGTATTATCTCAATTCAAATGGAGCAATGGTT
  ACAGGTAGTCAAACTATCGATGGTAAAGTTTATAACTTCGCTTCATCTGGTGAGTGGATT
  TAA
  60
  120
  180
  240
  300
  360
  420
  480
  540
  600
  660
  720
  780
  840
  900
  960
  963
  

⊟Protein

⊟General

• locus tag: T308_RS01865 [old locus tag: T308_01870 ]
• symbol: CbpC
• description: choline-binding protein CbpC
• length: 320
• theoretical pI: 6.30238
• theoretical MW: 37133.3
• GRAVY: -0.673437

⊟Function

• TIGRFAM:
  glucan-binding repeat (TIGR04035; HMM-score: 78.2)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  Choline_binding (CL0694) Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 140.7)
  Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 119.9)
  and 4 more
  Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 21.7)
  no clan defined CoV_S1_C; Coronavirus spike glycoprotein S1, C-terminal (PF19209; HMM-score: 11.4)
  DUF5754; Family of unknown function (DUF5754) (PF19058; HMM-score: 9.8)
  Phage_Orf51; Phage Conserved Open Reading Frame 51 (PF06194; HMM-score: 7.4)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: Extracellular
  • Cytoplasmic Score: 0.01
  • Cytoplasmic Membrane Score: 0.09
  • Cellwall Score: 0.18
  • Extracellular Score: 9.72
  • Internal Helix: 1
• DeepLocPro: Extracellular
  • Cytoplasmic Score: 0
  • Cytoplasmic Membrane Score: 0.0009
  • Cell wall & surface Score: 0.1318
  • Extracellular Score: 0.8673
• SignalP: Signal peptide SP(Sec/SPI) length 27 aa
  • SP(Sec/SPI): 0.994714
  • TAT(Tat/SPI): 0.001256
  • LIPO(Sec/SPII): 0.002932
  • Cleavage Site: CS pos: 27-28. VFA-NT. Pr: 0.9733
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: WP_000698035 NCBI
• UniProt:

⊟Protein sequence

• MKILKKMMQVLLAVFFFGLLATNTVFANTTGGRFVDKDNRKYYVKDDHKAIYWHKIDGKTYYFGDGGEMVVGWQYLEIPGTGYRDNLFDNQPVNEIGLQEKWYYFGQDGALLEQTDKQVLEAKTSENTGKVYGEQYPLSAEKRTYYFDNNYVVKTGWIYEDGNWYYLNKLGNFGDDSYNPLPIGEVAKGWTQDFHVTIDIDRSKPAPWYYLDASGKMLTDWQKVNGKWYYFGSSGSMATGWKYVRGKWYYLDNKNGDMKTGWYQDGSTWYYLDPSNGDMKIGWTKVNGKWYYLNSNGAMVTGSQTIDGKVYNFASSGEWI

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0345 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You are kindly invited to share additional interesting facts.

⊟Literature

⊟References

⊟Relevant publications