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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS10815 [old locus tag: SPH_2207 ]
  • symbol: comGA
  • product: competence type IV pilus ATPase ComGA
  • replicon: chromosome
  • strand: -
  • coordinates: 2026403..2027344
  • length: 942
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: NC_010380 (2026403..2027344) NCBI
  • BioCyc: SPH_RS10815 BioCyc
  • MicrobesOnline: see SPH_2207
  • PneumoBrowse for strain D39V: SPV_1863 PneumoBrowse

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGTTCAAGAAATTGCACAAGAAATCATTCGCTCGGCTCGGAAAAAAGGGGCGCAAGAC
    ATTTATTTTGTCCCCAAGTTAGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGC
    TGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCGTTATCAGTCACTTTAAGTTT
    GTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
    TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAG
    AGTTTGGTTATCCGTTTGTTGCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGAT
    ATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCTATCTTTTTGCTGGTCCGGTT
    GGAAGTGGTAAGACGACCTTGATGCATGGATTGTCCAAGTCACTCTTTAAAGGACAGCAA
    GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGATATGCTTCAGTTGCAGTTG
    AACGAAGCAATCGGCCTAACCTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCA
    GATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGGCGCGTGCAGTGGTCAGAGCT
    AGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
    GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTC
    TGCTACCAGAGATTAATCGGGGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAA
    GAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGCTTCTTAAAGATGGACATATC
    ACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    942

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SPH_RS10815 [old locus tag: SPH_2207 ]
  • symbol: ComGA
  • description: competence type IV pilus ATPase ComGA
  • length: 313
  • theoretical pI: 6.19015
  • theoretical MW: 35489.2
  • GRAVY: -0.314377

Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Pathogenesis type II secretion system protein E (TIGR02533; HMM-score: 148.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type II secretion system protein E (TIGR02533; HMM-score: 148.5)
    Cell structure Cell envelope Surface structures type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 127.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 127.2)
    and 20 more
    Cell structure Cell envelope Surface structures twitching motility protein (TIGR01420; HMM-score: 93.9)
    Cellular processes Cellular processes Chemotaxis and motility twitching motility protein (TIGR01420; HMM-score: 93.9)
    Genetic information processing Mobile and extrachromosomal element functions Plasmid functions plasmid transfer ATPase TraJ (TIGR02525; HMM-score: 63.1)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 55.3)
    helicase/secretion neighborhood ATPase (TIGR03819; HMM-score: 53)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 50.2)
    Dot/Icm secretion system ATPase DotB (TIGR02524; HMM-score: 45.4)
    Cellular processes Cellular processes Sporulation and germination stage III sporulation protein AA (TIGR02858; HMM-score: 26.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative secretion ATPase, PEP-CTERM locus subfamily (TIGR03015; HMM-score: 22.6)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 16.4)
    Metabolism Central intermediary metabolism Nitrogen metabolism urease accessory protein UreG (TIGR00101; HMM-score: 16.2)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 14.9)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 12.9)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 12.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 12.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 12.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair checkpoint protein rad24 (TIGR00602; HMM-score: 12)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 11.7)
    Cellular processes Cellular processes Pathogenesis type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.2)
  • TheSEED: see SPH_2207
  • PFAM:
    P-loop_NTPase (CL0023) T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 169.3)
    and 24 more
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 20.5)
    AAA_14; AAA domain (PF13173; HMM-score: 19.7)
    SRPRB; Signal recognition particle receptor beta subunit (PF09439; HMM-score: 19.2)
    AAA_23; AAA domain (PF13476; HMM-score: 19.1)
    Rad17; Rad17 P-loop domain (PF03215; HMM-score: 18.2)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 17)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 16.5)
    AAA_18; AAA domain (PF13238; HMM-score: 15.6)
    AAA_22; AAA domain (PF13401; HMM-score: 15.1)
    AFG1_ATPase; AFG1-like ATPase (PF03969; HMM-score: 14.9)
    dNK; Deoxynucleoside kinase (PF01712; HMM-score: 14.7)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 14.5)
    AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 13.8)
    AAA_33; AAA domain (PF13671; HMM-score: 13.8)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 13.5)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 13.4)
    AAA_30; AAA domain (PF13604; HMM-score: 13.2)
    ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 12.8)
    NACHT; NACHT domain (PF05729; HMM-score: 12.8)
    AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 12.5)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 12.5)
    AAA_25; AAA domain (PF13481; HMM-score: 12.5)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 12.3)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 12)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.89
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004211
    • TAT(Tat/SPI): 0.000328
    • LIPO(Sec/SPII): 0.000576
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHGLSKSLFKGQQVMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Regulation[edit | edit source]

Expression data[edit | edit source]

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]

NCBI: 24-APR-2024

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_RS10815 [old locus tag: SPH_2207 ]
  • pan locus tag?: PNEUPAN003806000
  • symbol: comGA
  • pan gene symbol?: comGA
  • synonym:
  • product: competence type IV pilus ATPase ComGA

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: SPH_RS10815 [old locus tag: SPH_2207 ]
  • symbol: comGA
  • product: competence type IV pilus ATPase ComGA
  • replicon: chromosome
  • strand: -
  • coordinates: 2026403..2027344
  • length: 942
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: NC_010380 (2026403..2027344) NCBI
  • BioCyc: SPH_RS10815 BioCyc
  • MicrobesOnline: see SPH_2207
  • PneumoBrowse for strain D39V: SPV_1863 PneumoBrowse

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    ATGGTTCAAGAAATTGCACAAGAAATCATTCGCTCGGCTCGGAAAAAAGGGGCGCAAGAC
    ATTTATTTTGTCCCCAAGTTAGACGCCTATGAGCTTCATATGAGGGTAGGAGACGAGCGC
    TGTAAAATTGGTAGCTATGATTTTGAAAAGTTTGCAGCCGTTATCAGTCACTTTAAGTTT
    GTGGCGGGTATGAATGTGGGAGAAAAAAGACGTAGTCAACTGGGTTCCTGTGATTATGCC
    TATGACCAGAAGATGGCGTCTCTACGTTTATCTACTGTAGGCGATTATCGGGGGCATGAG
    AGTTTGGTTATCCGTTTGTTGCACGATGAGGAGCAGGACTTGCATTTTTGGTTTCAGGAT
    ATTGAAGAATTAGGCAAGCAGTACAGGCAACGGGGACTCTATCTTTTTGCTGGTCCGGTT
    GGAAGTGGTAAGACGACCTTGATGCATGGATTGTCCAAGTCACTCTTTAAAGGACAGCAA
    GTTATGTCCATCGAAGATCCTGTCGAAATCAAGCAGGACGATATGCTTCAGTTGCAGTTG
    AACGAAGCAATCGGCCTAACCTATGAAAATCTAATCAAACTTTCCTTGCGTCATCGACCA
    GATCTCTTGATTATCGGAGAAATTCGTGACAGCGAGACGGCGCGTGCAGTGGTCAGAGCT
    AGTTTGACAGGTGCGACAGTCTTTTCAACCATTCACGCCAAGAGTATCCGAGGTGTTTAT
    GAGCGTCTGCTGGAGTTGGGTGTGAGTGAAGAAGAATTGGCAGTTGTTCTGCAAGGAGTC
    TGCTACCAGAGATTAATCGGGGGAGGAGGAATCGTTGACTTTGCAAACAGAGATTATCAA
    GAACACCAAGCAGCCAAGTGGAATGAGCAAATTGACCAGCTTCTTAAAGATGGACATATC
    ACAAGTCTTCAGGCTGAGACGGAAAAAATTAGCTACAGCTAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    942

This data comes from external databases and cannot be edited.

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: SPH_RS10815 [old locus tag: SPH_2207 ]
  • symbol: ComGA
  • description: competence type IV pilus ATPase ComGA
  • length: 313
  • theoretical pI: 6.19015
  • theoretical MW: 35489.2
  • GRAVY: -0.314377

Function[edit | edit source]

  • TIGRFAM:
    Cellular processes Cellular processes Pathogenesis type II secretion system protein E (TIGR02533; HMM-score: 148.5)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type II secretion system protein E (TIGR02533; HMM-score: 148.5)
    Cell structure Cell envelope Surface structures type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 127.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type IV-A pilus assembly ATPase PilB (TIGR02538; HMM-score: 127.2)
    and 20 more
    Cell structure Cell envelope Surface structures twitching motility protein (TIGR01420; HMM-score: 93.9)
    Cellular processes Cellular processes Chemotaxis and motility twitching motility protein (TIGR01420; HMM-score: 93.9)
    Genetic information processing Mobile and extrachromosomal element functions Plasmid functions plasmid transfer ATPase TraJ (TIGR02525; HMM-score: 63.1)
    P-type DNA transfer ATPase VirB11 (TIGR02788; HMM-score: 55.3)
    helicase/secretion neighborhood ATPase (TIGR03819; HMM-score: 53)
    Cellular processes Cellular processes Conjugation P-type conjugative transfer ATPase TrbB (TIGR02782; HMM-score: 50.2)
    Dot/Icm secretion system ATPase DotB (TIGR02524; HMM-score: 45.4)
    Cellular processes Cellular processes Sporulation and germination stage III sporulation protein AA (TIGR02858; HMM-score: 26.8)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking putative secretion ATPase, PEP-CTERM locus subfamily (TIGR03015; HMM-score: 22.6)
    Genetic information processing Protein synthesis tRNA and rRNA base modification tRNA threonylcarbamoyl adenosine modification protein YjeE (TIGR00150; HMM-score: 16.4)
    Metabolism Central intermediary metabolism Nitrogen metabolism urease accessory protein UreG (TIGR00101; HMM-score: 16.2)
    Cellular processes Cellular processes Chemotaxis and motility flagellar biosynthesis protein FlhF (TIGR03499; HMM-score: 14.9)
    Metabolism Transport and binding proteins Anions phosphate ABC transporter, ATP-binding protein (TIGR00972; EC 3.6.3.27; HMM-score: 12.9)
    Genetic information processing Protein fate Protein folding and stabilization ATP-dependent chaperone protein ClpB (TIGR03346; HMM-score: 12.9)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DnaA regulatory inactivator Hda (TIGR03420; HMM-score: 12.6)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, subunit gamma and tau (TIGR02397; EC 2.7.7.7; HMM-score: 12.4)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair checkpoint protein rad24 (TIGR00602; HMM-score: 12)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA polymerase III, delta' subunit (TIGR00678; EC 2.7.7.7; HMM-score: 11.7)
    Cellular processes Cellular processes Pathogenesis type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.2)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type VI secretion ATPase, ClpV1 family (TIGR03345; HMM-score: 11.2)
  • TheSEED: see SPH_2207
  • PFAM:
    P-loop_NTPase (CL0023) T2SSE; Type II/IV secretion system protein (PF00437; HMM-score: 169.3)
    and 24 more
    TsaE; Threonylcarbamoyl adenosine biosynthesis protein TsaE (PF02367; HMM-score: 20.5)
    AAA_14; AAA domain (PF13173; HMM-score: 19.7)
    SRPRB; Signal recognition particle receptor beta subunit (PF09439; HMM-score: 19.2)
    AAA_23; AAA domain (PF13476; HMM-score: 19.1)
    Rad17; Rad17 P-loop domain (PF03215; HMM-score: 18.2)
    AAA; ATPase family associated with various cellular activities (AAA) (PF00004; HMM-score: 17)
    AAA_29; P-loop containing region of AAA domain (PF13555; HMM-score: 16.5)
    AAA_18; AAA domain (PF13238; HMM-score: 15.6)
    AAA_22; AAA domain (PF13401; HMM-score: 15.1)
    AFG1_ATPase; AFG1-like ATPase (PF03969; HMM-score: 14.9)
    dNK; Deoxynucleoside kinase (PF01712; HMM-score: 14.7)
    Zeta_toxin; Zeta toxin (PF06414; HMM-score: 14.5)
    AAA_2; AAA domain (Cdc48 subfamily) (PF07724; HMM-score: 13.8)
    AAA_33; AAA domain (PF13671; HMM-score: 13.8)
    ResIII; Type III restriction enzyme, res subunit (PF04851; HMM-score: 13.5)
    cobW; CobW/HypB/UreG, nucleotide-binding domain (PF02492; HMM-score: 13.4)
    AAA_30; AAA domain (PF13604; HMM-score: 13.2)
    ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 12.8)
    NACHT; NACHT domain (PF05729; HMM-score: 12.8)
    AAA_5; AAA domain (dynein-related subfamily) (PF07728; HMM-score: 12.5)
    Roc; Ras of Complex, Roc, domain of DAPkinase (PF08477; HMM-score: 12.5)
    AAA_25; AAA domain (PF13481; HMM-score: 12.5)
    AAA_7; P-loop containing dynein motor region (PF12775; HMM-score: 12.3)
    RNA_helicase; RNA helicase (PF00910; HMM-score: 12)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 9.89
    • Cytoplasmic Membrane Score: 0.09
    • Cellwall Score: 0.01
    • Extracellular Score: 0.02
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004211
    • TAT(Tat/SPI): 0.000328
    • LIPO(Sec/SPII): 0.000576
  • predicted transmembrane helices (TMHMM): 0

Accession numbers[edit | edit source]

Protein sequence[edit | edit source]

  • MVQEIAQEIIRSARKKGAQDIYFVPKLDAYELHMRVGDERCKIGSYDFEKFAAVISHFKFVAGMNVGEKRRSQLGSCDYAYDQKMASLRLSTVGDYRGHESLVIRLLHDEEQDLHFWFQDIEELGKQYRQRGLYLFAGPVGSGKTTLMHGLSKSLFKGQQVMSIEDPVEIKQDDMLQLQLNEAIGLTYENLIKLSLRHRPDLLIIGEIRDSETARAVVRASLTGATVFSTIHAKSIRGVYERLLELGVSEEELAVVLQGVCYQRLIGGGGIVDFANRDYQEHQAAKWNEQIDQLLKDGHITSLQAETEKISYS

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Regulation[edit | edit source]

Expression data[edit | edit source]

Biological Material[edit | edit source]

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

This data comes from external databases and cannot be edited.

Other Information[edit | edit source]

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]