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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS02090 [old locus tag: SP_0423 ]
  • pan locus tag?: PNEUPAN001267000
  • symbol: accB
  • pan gene symbol?: accB
  • synonym:
  • product: acetyl-CoA carboxylase biotin carboxyl carrier protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS02090 [old locus tag: SP_0423 ]
  • symbol: accB
  • product: acetyl-CoA carboxylase biotin carboxyl carrier protein
  • replicon: chromosome
  • strand: +
  • coordinates: 400947..401432
  • length: 486
  • essential: yes [1] DEG

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (400947..401432) NCBI
  • BioCyc:
  • MicrobesOnline: see SP_0423
  • PneumoBrowse for strain D39V: SPV_0386 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    ATGAATTTAAACGATATTAAAGACTTGATGACTCAATTTGACCAGTCAAGTTTGAGAGAA
    TTTTCTTATAAAAATGGGACGGATGAGTTGCAGTTTAGCAAGAATGAAGCAAGACCTGTG
    CCTGAAGTTGCAACTCAAGTCGCTCCAGCACCCGTTCTAGCAACACCGAGTCCAGTAGCT
    CCTACATCTGCTCCAGCAGAGACTGTAGCAGAAGAAGTTCCAGCTCCAGCTGAAGCAAGT
    GTGGCTACTGAGGGAAATCTTGTAGAGAGTCCACTTGTTGGAGTGGTTTACTTGGCTGCT
    GGACCAGATAAACCTGCCTTCGTTACAGTTGGTGATAGTGTCAAAAAAGGTCAAACATTG
    GTAATTATCGAAGCCATGAAAGTCATGAATGAAATCCCAGCTCCTAAGGATGGTGTGGTA
    ACGGAAATTCTCGTCTCTAACGAAGAAATGGTTGAGTTTGGTAAAGGATTGGTACGTATC
    AAATGA
    60
    120
    180
    240
    300
    360
    420
    480
    486

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS02090 [old locus tag: SP_0423 ]
  • symbol: AccB
  • description: acetyl-CoA carboxylase biotin carboxyl carrier protein
  • length: 161
  • theoretical pI: 4.17105
  • theoretical MW: 17033.3
  • GRAVY: -0.0192547

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 6.4.1.2?  ExPASy
    Acetyl-CoA carboxylase ATP + acetyl-CoA + HCO3(-) = ADP + phosphate + malonyl-CoA
  • ⊞TIGRFAM:
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis acetyl-CoA carboxylase, biotin carboxyl carrier protein (TIGR00531; HMM-score: 139.6)
    and 13 more
    Metabolism Transport and binding proteins Cations and iron carrying compounds oxaloacetate decarboxylase alpha subunit (TIGR01108; EC 4.1.1.3; HMM-score: 40.6)
    Metabolism Energy metabolism Other oxaloacetate decarboxylase alpha subunit (TIGR01108; EC 4.1.1.3; HMM-score: 40.6)
    Metabolism Central intermediary metabolism Nitrogen metabolism urea carboxylase (TIGR02712; EC 6.3.4.6; HMM-score: 40.5)
    Metabolism Energy metabolism Pyruvate dehydrogenase dihydrolipoyllysine-residue acetyltransferase (TIGR01348; EC 2.3.1.12; HMM-score: 33.8)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis pyruvate carboxylase (TIGR01235; EC 6.4.1.1; HMM-score: 31.7)
    Metabolism Energy metabolism TCA cycle dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex (TIGR01347; EC 2.3.1.61; HMM-score: 31.3)
    2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase (TIGR02927; EC 2.3.1.61; HMM-score: 27.7)
    Metabolism Transport and binding proteins Unknown substrate efflux transporter, RND family, MFP subunit (TIGR01730; HMM-score: 24.6)
    glycine cleavage protein H-like protein (TIGR03077; HMM-score: 16.2)
    Metabolism Energy metabolism Amino acids and amines glycine cleavage system H protein (TIGR00527; HMM-score: 16.1)
    Genetic information processing Protein fate Protein and peptide secretion and trafficking type I secretion membrane fusion protein, HlyD family (TIGR01843; HMM-score: 12.8)
    Cellular processes Cellular processes Biosynthesis of natural products NHLM bacteriocin system secretion protein (TIGR03794; HMM-score: 11.3)
    Metabolism Transport and binding proteins Amino acids, peptides and amines NHLM bacteriocin system secretion protein (TIGR03794; HMM-score: 11.3)
  • TheSEED: see SP_0423
  • ⊞PFAM:
    Hybrid (CL0105) Biotin_lipoyl; Biotin-requiring enzyme (PF00364; HMM-score: 72.9)
    and 6 more
    Biotin_lipoyl_2; Biotin-lipoyl like (PF13533; HMM-score: 24.9)
    GCV_H; Glycine cleavage H-protein (PF01597; HMM-score: 21.3)
    RnfC_N; RnfC Barrel sandwich hybrid domain (PF13375; HMM-score: 17.3)
    HlyD_D23; Barrel-sandwich domain of CusB or HlyD membrane-fusion (PF16576; HMM-score: 14.6)
    no clan defined DEC-1_N; DEC-1 protein, N-terminal region (PF04625; HMM-score: 12.4)
    POTRA (CL0191) YqfD; Putative stage IV sporulation protein YqfD (PF06898; HMM-score: 11)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • ⊞DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.8974
    • Cytoplasmic Membrane Score: 0.0724
    • Cell wall & surface Score: 0.0009
    • Extracellular Score: 0.0293
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.027977
    • TAT(Tat/SPI): 0.069952
    • LIPO(Sec/SPII): 0.00266
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNLNDIKDLMTQFDQSSLREFSYKNGTDELQFSKNEARPVPEVATQVAPAPVLATPSPVAPTSAPAETVAEEVPAPAEASVATEGNLVESPLVGVVYLAAGPDKPAFVTVGDSVKKGQTLVIIEAMKVMNEIPAPKDGVVTEILVSNEEMVEFGKGLVRIK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)    Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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