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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 23-APR-2024

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_RS02100 [old locus tag: SP_0425 ]
  • pan locus tag?: PNEUPAN001314000
  • symbol: accC
  • pan gene symbol?: accC
  • synonym:
  • product: acetyl-CoA carboxylase biotin carboxylase subunit

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_RS02100 [old locus tag: SP_0425 ]
  • symbol: accC
  • product: acetyl-CoA carboxylase biotin carboxylase subunit
  • replicon: chromosome
  • strand: +
  • coordinates: 401863..403230
  • length: 1368
  • essential: yes [1] DEG

⊟Accession numbers[edit | edit source]

  • Location: NC_003028 (401863..403230) NCBI
  • BioCyc: SP_RS02100 BioCyc
  • MicrobesOnline: see SP_0425
  • PneumoBrowse for strain D39V: SPV_0388 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    ATGTTTCGAAAAATTTTAATTGCCAATCGTGGTGAAATTGCGGTTCGTATTATCCGTGCG
    GCACGTGAATTGGGGATTGCGACGGTAGCGGTTTATTCAACTGCTGATAAGGAAGCTCTT
    CATACGCTTTTGGCAGATGAAGCAGTTTGTATTGGTCCTGGCAAGGCAACAGAGTCTTAT
    CTCAATATTAATGCAGTTCTATCAGCTGCAGTCTTGACTGAGGCAGAAGCTATTCACCCT
    GGTTTTGGATTTCTCAGTGAAAATTCCAAATTTGCGACCATGTGTGAAGAAGTAGGTATC
    AAGTTTATCGGTCCATCTGGTCATGTTATGGATATGATGGGGGATAAGATCAATGCGCGT
    GCTCAGATGATTAAAGCAGGTGTGCCTGTTATACCAGGTTCAGATGGAGAAGTGCATAAC
    TCTGAAGAAGCTTTGATTGTTGCTGAAAAAATTGGCTATCCTGTTATGCTCAAGGCTTCA
    GCAGGTGGAGGTGGTAAAGGGATTCGTAAGGTTGAAAAACCAGATGACCTCGTTTCTGCC
    TTTGAAACTGCCTCTAGTGAGGCCAAGGCCAATTATGGCAATGGTGCCATGTACATAGAA
    CGGGTTATCTATCCAGCTCGGCACATTGAGGTTCAAATCCTAGGTGATGAGCATGGACAT
    GTGATTCACTTGGGTGAACGGGATTGTTCTCTTCAAAGGAATAACCAAAAGGTTTTGGAA
    GAAAGTCCCTCGATTGCAATCGGAAAAACGCTGCGTCATGAAATAGGTGCTGCTGCTGTT
    CGAGCGGCAGAGTTTGTTGGCTATGAGAATGCAGGAACCATTGAATTTCTTCTTGATGAA
    GCAAGTAGCAATTTCTATTTCATGGAGATGAATACTCGTGTTCAGGTAGAACATCCAGTA
    ACAGAGTTTGTTTCAGGTGTTGATATCGTTAAGGAACAGATTTGCATTGCGGCAGGTCAG
    CCTTTGTCTGTTAAGCAAGAAGATATTGTCCTACGCGGTCATGCCATCGAGTGTCGTATC
    AATGCAGAAAACCCAGCCTTTAACTTTGCTCCAAGTCCAGGTAAGATTACTAATCTCTAT
    CTGCCAAGTGGTGGAGTTGGCTTGCGCGTGGATTCAGCAGTTTATCCAGGTTATACCATT
    CCGCCTTATTATGATAGTATGATTGCCAAAATCATAGTACACGGCGAAAATCGTTTTGAC
    GCCTTGATGAAAATGCAACGTGCCCTCTATGAATTAGAAATTGAAGGAGTGCAGACCAAT
    GCAGATTTCCAGCTTGACCTCATTTCAGATCGCAATGTCATTGCTGGGGATTATGATACT
    TCCTTCTTGATGGAAACCTTCTTACCTAAATATCAAGAAAAAGAATAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1368

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_RS02100 [old locus tag: SP_0425 ]
  • symbol: AccC
  • description: acetyl-CoA carboxylase biotin carboxylase subunit
  • length: 455
  • theoretical pI: 4.85858
  • theoretical MW: 49539.2
  • GRAVY: -0.0432967

⊟Function[edit | edit source]

  • ⊞reaction:
    EC 6.3.4.14?  ExPASy
    Biotin carboxylase ATP + biotin-[carboxyl-carrier-protein] + HCO3(-) = ADP + phosphate + carboxy-biotin-[carboxyl-carrier-protein]
  • ⊞TIGRFAM:
    Metabolism Fatty acid and phospholipid metabolism Biosynthesis acetyl-CoA carboxylase, biotin carboxylase subunit (TIGR00514; EC 6.3.4.14; HMM-score: 674.4)
    Metabolism Energy metabolism Glycolysis/gluconeogenesis pyruvate carboxylase (TIGR01235; EC 6.4.1.1; HMM-score: 548.6)
    Metabolism Central intermediary metabolism Nitrogen metabolism urea carboxylase (TIGR02712; EC 6.3.4.6; HMM-score: 539.6)
    and 7 more
    alpha-L-glutamate ligase, RimK family (TIGR00768; EC 6.3.2.-; HMM-score: 50.4)
    lysine biosynthesis enzyme LysX (TIGR02144; HMM-score: 49.8)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan D-alanine--D-alanine ligase (TIGR01205; EC 6.3.2.4; HMM-score: 49.1)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Pyrimidine ribonucleotide biosynthesis carbamoyl-phosphate synthase, large subunit (TIGR01369; EC 6.3.5.5; HMM-score: 36.4)
    Cellular processes Cellular processes Biosynthesis of natural products cyanophycin synthetase (TIGR02068; EC 6.3.2.29,6.3.2.30; HMM-score: 31.5)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylglycinamide formyltransferase 2 (TIGR01142; EC 2.1.2.-; HMM-score: 24.7)
    Metabolism Purines, pyrimidines, nucleosides, and nucleotides Purine ribonucleotide biosynthesis phosphoribosylamine--glycine ligase (TIGR00877; EC 6.3.4.13; HMM-score: 18.1)
  • TheSEED: see SP_0425
  • ⊞PFAM:
    ATP-grasp (CL0179) CPSase_L_D2; Carbamoyl-phosphate synthase L chain, ATP binding domain (PF02786; HMM-score: 241.3)
    and 7 more
    PreATP-grasp (CL0483) Biotin_carb_N; Biotin carboxylase, N-terminal domain (PF00289; HMM-score: 153.7)
    Hybrid (CL0105) Biotin_carb_C; Biotin carboxylase C-terminal domain (PF02785; HMM-score: 132.4)
    ATP-grasp (CL0179) Dala_Dala_lig_C; D-ala D-ala ligase C-terminus (PF07478; HMM-score: 49.5)
    ATP-grasp; ATP-grasp domain (PF02222; HMM-score: 23.9)
    RimK; RimK-like ATP-grasp domain (PF08443; HMM-score: 14.6)
    ATP-grasp_4; ATP-grasp domain (PF13535; HMM-score: 12.7)
    ATP-grasp_3; ATP-grasp domain (PF02655; HMM-score: 12.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • ⊞PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • ⊞SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.052372
    • TAT(Tat/SPI): 0.007584
    • LIPO(Sec/SPII): 0.005732
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFRKILIANRGEIAVRIIRAARELGIATVAVYSTADKEALHTLLADEAVCIGPGKATESYLNINAVLSAAVLTEAEAIHPGFGFLSENSKFATMCEEVGIKFIGPSGHVMDMMGDKINARAQMIKAGVPVIPGSDGEVHNSEEALIVAEKIGYPVMLKASAGGGGKGIRKVEKPDDLVSAFETASSEAKANYGNGAMYIERVIYPARHIEVQILGDEHGHVIHLGERDCSLQRNNQKVLEESPSIAIGKTLRHEIGAAAVRAAEFVGYENAGTIEFLLDEASSNFYFMEMNTRVQVEHPVTEFVSGVDIVKEQICIAAGQPLSVKQEDIVLRGHAIECRINAENPAFNFAPSPGKITNLYLPSGGVGLRVDSAVYPGYTIPPYYDSMIAKIIVHGENRFDALMKMQRALYELEIEGVQTNADFQLDLISDRNVIAGDYDTSFLMETFLPKYQEKE

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊞Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊞Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)

⊟Relevant publications[edit | edit source]

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