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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 09-DEC-2016

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SP49
  • locus tag: BMJ42_01682 [new locus tag: BMJ42_RS08865 ]
  • pan locus tag?: PNEUPAN003090000
  • symbol: BMJ42_01682
  • pan gene symbol?: nanR
  • synonym:
  • product: phosphosugar-binding transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: BMJ42_01682 [new locus tag: BMJ42_RS08865 ]
  • symbol: BMJ42_01682
  • product: phosphosugar-binding transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 1590465..1591316
  • length: 852
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    ATGGACAAACCAGATATCGCAACTATCATTGATTCACATTTTGAAGAAATGACAGACCTA
    GAGCAAGAAATCGCTCGCTATTTTTTGCAAGCTGAAACGATTACAGATGATTTATCTTCT
    CAACAAGTCACCCAAAAATTACATATTTCTCAAGCTGCTTTGACCCGCTTTGCTAAAAAG
    TGTGGCTTTACTGGCTACCGAGAATTTATTTTCCAATACCAACATCAGGCAGAAAATCAA
    GCCAACCAAGTTTCCAAGCACAGTCCACTGACCAAACGAGTCCTCAGAAGTTATAGCAAC
    ATGAGGGAACAAACACAAGACTTGATTGACGAAATCCAACTAGAGCGAATTGCCCAGCTA
    ATCGAAGATGCTGAGCGTATCTACTTCTTTGGAACAGGGAGTTCTGGCCTCGTCGCCCGT
    GAAATGAAATTACGTTTTATGCGACTAGGTGTGGTCTGCGAAGCTTTGACAGACCAAGAC
    GGCTTTGCCTGGACAACCAGCATCATGGATGAAAATTGTCTAGTACTGGGTTTCTCACTT
    TCAGGCTCAACTCCTTCTATTTTAGATAGTCTATTAGATGCCAAGGAGATGGGGGCAAAG
    ACTGTACTCTTTACAAGTGTTCCCAATAAAGATAGCCAGACCTATACAGAGACTGTTCTT
    GTAGCCACCCACAGCCAACCCTCCTACATCCAACGAATATCCGCTCAACTTCCTATGCTC
    TTCTTTATCGATTTGATTTATGCCTACTTTTTGGAAATCAATCGCGAAAGCAAGGAAAAA
    ATCTTTAATAGCTACTGGGAAAATAAAAAACTCAACGGCTATCGTAGACAAAAACGTGTA
    AGAAAATCCTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    852

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: BMJ42_01682 [new locus tag: BMJ42_RS08865 ]
  • symbol: BMJ42_01682
  • description: phosphosugar-binding transcriptional regulator
  • length: 283
  • theoretical pI: 6.05809
  • theoretical MW: 32670.9
  • GRAVY: -0.387986

⊟Function[edit | edit source]

  • TIGRFAM:
    6-phospho 3-hexuloisomerase (TIGR03127; EC 5.3.-.-; HMM-score: 53.1)
    and 6 more
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan N-acetylmuramic acid 6-phosphate etherase (TIGR00274; EC 4.2.1.126; HMM-score: 19.8)
    bifunctional phosphoglucose/phosphomannose isomerase (TIGR02128; EC 5.3.1.9; HMM-score: 18.1)
    Cell structure Cell envelope Biosynthesis and degradation of murein sacculus and peptidoglycan glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 17.5)
    Metabolism Central intermediary metabolism Amino sugars glutamine-fructose-6-phosphate transaminase (isomerizing) (TIGR01135; EC 2.6.1.16; HMM-score: 17.5)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides phosphoheptose isomerase (TIGR00441; EC 5.3.1.28; HMM-score: 13.5)
    rad50 (TIGR00606; HMM-score: 10.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    SIS (CL0067) SIS; SIS domain (PF01380; HMM-score: 58.8)
    HTH (CL0123) HTH_6; Helix-turn-helix domain, rpiR family (PF01418; HMM-score: 49.9)
    and 4 more
    SIS (CL0067) SIS_2; SIS domain (PF13580; HMM-score: 31.6)
    Transthyretin (CL0287) DUF3869; Domain of unknown function (DUF3869) (PF12985; HMM-score: 14.8)
    no clan defined DUF6756; Family of unknown function (DUF6756) (PF20541; HMM-score: 12.9)
    RNase_E_G; Ribonuclease E/G family (PF10150; HMM-score: 11.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:
  • genes regulated by 
    NanRTF important in Sialic acid utilization: in D39V
    NanR*TF important in Sialic acid utilization: in TIGR4

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9367
    • Cytoplasmic Membrane Score: 0.0623
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.001
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.007025
    • TAT(Tat/SPI): 0.001205
    • LIPO(Sec/SPII): 0.000295
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: APJ30970 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MDKPDIATIIDSHFEEMTDLEQEIARYFLQAETITDDLSSQQVTQKLHISQAALTRFAKKCGFTGYREFIFQYQHQAENQANQVSKHSPLTKRVLRSYSNMREQTQDLIDEIQLERIAQLIEDAERIYFFGTGSSGLVAREMKLRFMRLGVVCEALTDQDGFAWTTSIMDENCLVLGFSLSGSTPSILDSLLDAKEMGAKTVLFTSVPNKDSQTYTETVLVATHSQPSYIQRISAQLPMLFFIDLIYAYFLEINRESKEKIFNSYWENKKLNGYRRQKRVRKS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Muhammad Afzal, Sulman Shafeeq, Hifza Ahmed, Oscar P Kuipers
Sialic acid-mediated gene expression in Streptococcus pneumoniae and role of NanR as a transcriptional activator of the nan gene cluster.
Appl Environ Microbiol: 2015, 81(9);3121-31
[PubMed:25724955] [WorldCat.org] [DOI] (I p)

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