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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 16-MAY-2019

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae EF3030
  • locus tag: EF3030_04650 [new locus tag: EF3030_RS04650 ]
  • pan locus tag?: PNEUPAN001964000
  • symbol: pavA
  • pan gene symbol?: pavA
  • synonym:
  • product: fibronectin-binding protein PavA

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: EF3030_04650 [new locus tag: EF3030_RS04650 ]
  • symbol: pavA
  • product: fibronectin-binding protein PavA
  • replicon: chromosome
  • strand: -
  • coordinates: 870549..872204
  • length: 1656
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGTCATTTGACGGATTTTTTTTACACCACATAGTTGAGGAATTGCGAAGCGAATTAGTG
    AATGGTCGCATCCAGAAAATCAATCAGCCTTTTGAACAAGAGTTGGTCTTGCAAATCCGC
    AGCAATCGCCAAAGCCATCGCCTGCTCCTTTCTGCCCATCCAGTTTTTGGACGCATTCAG
    CTGACCCAAACGACTTTTGAAAATCCAGCTCAACCTTCTACCTTTATCATGGTTTTGAGA
    AAGTATTTGCAGGGGGCCCTGATTGAGTCGATTGAGCAAGTGGAAAATGACCGTATTGTG
    GAAATTACAGTTTCCAATAAAAACGAGATTGGAGACCATATCCAGGCTACCTTGATTATC
    GAAATTATGGGGAAACACAGTAATATTCTACTGGTCGATAAAAGCAGTCATAAAATCCTC
    GAAGTTATCAAACACGTCGGCTTTTCACAAAATAGCTACCGCACCTTACTTCCAGGATCG
    ACCTATATCGCTCCGCCAAGTACAAAATCTCTCAATCCTTTTACTATCAAGGATGAAAAG
    CTCTTTGAAATCCTGCAAACCCAAGAACTAACAGCAAAAAATCTTCAAAGCCTCTTTCAA
    GGTCTGGGACGCGATACGGCAAATGAATTGGAAAGGATACTGGTTAGTGAAAAACTTTCC
    GCTTTCCGAAATTTTTTCAATCAAGAAACCAAGCCATGCTTGACTGAGACTTCCTTCAGT
    CCAGTTCCTTTTGCAAATCAGGTGGGAGAGCCTTTTGCAAATCTTTCTGATTTGTTGGAC
    ACCTACTATAAGGATAAGGCTGAGCGCGACCGCGTCAAACAGCAGGCCAGTGAACTGATT
    CGTCGTGTTGAAAATGAACTTCAGAAAAACCGACACAAACTCAAAAAACAGGAAAAAGAG
    TTACTGGCGACAGACAACGCTGAAGAATTTCGTCAAAAAGGAGAATTGCTGACAACCTTC
    CTCCACCAAGTGCCTAACGACCAAGACCAGGTTATCCTAGACAACTACTATACCAACCAA
    CCTATCATGATTGCGCTTGATAAGGCTCTGACTCCCAACCAGAATGCCCAACGCTATTTT
    AAACGGTATCAGAAACTCAAAGAAGCTGTCAAATACTTGACTGATTTGATTGAAGAAACC
    AAAGCCACTATTCTCTATCTGGAAAGTGTAGAAACCGTCCTCAACCAAGCTGGACTGGAA
    GAAATCGCTGAAATCCGTGAAGAATTGATTCAAACAGGTTTTATCCGCAGAAGACAACGG
    GAGAAAATCCAGAAACGCAAAAAACTAGAACAATATCTAGCAAGCGATGGCAAAACCATC
    ATCTATGTCGGACGAAACAATCTTCAAAATGAGGAATTGACCTTTAAAATGGCCCGCAAG
    GAGGAACTTTGGTTCCATGCTAAGGACATTCCTGGAAGCCATGTTGTCATCTCAGGAAAT
    CTTGACCCATCTGATGCAGTCAAGACAGACGCAGCAGAGTTAGCTGCCTACTTCTCTCAA
    GGGCGCCTGTCGAATCTGGTGCAGGTAGATATGATTGAAGTCAAAAAACTCAATAAACCA
    ACTGGTGGAAAACCCGGCTTTGTCACTTACACAGGACAAAAGACCCTCCGCGTCACACCA
    GACTCCAAAAAAATTGCATCCATGAAAAAATCCTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1656

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: EF3030_04650 [new locus tag: EF3030_RS04650 ]
  • symbol: PavA
  • description: fibronectin-binding protein PavA
  • length: 551
  • theoretical pI: 9.13313
  • theoretical MW: 63289.8
  • GRAVY: -0.517967

⊟Function[edit | edit source]

  • TIGRFAM:
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    H2TH (CL0303) NFACT_N; NFACT N-terminal and middle domains (PF05833; HMM-score: 497.5)
    and 6 more
    NFACT_RNA-bind (CL0684) NFACT-R_1; NFACT protein RNA binding domain (PF05670; HMM-score: 32.8)
    NFACT-R_2; NFACT protein RNA binding domain (PF18297; HMM-score: 30.8)
    no clan defined RbcX; RbcX protein (PF02341; HMM-score: 13.1)
    Siah-Interact_N; Siah interacting protein, N terminal (PF09032; HMM-score: 11.4)
    DUF5798; Family of unknown function (DUF5798) (PF19111; HMM-score: 10.7)
    ALC; Phage ALC protein (PF17527; HMM-score: 6.9)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.7293
    • Cytoplasmic Membrane Score: 0.0026
    • Cell wall & surface Score: 0.1039
    • Extracellular Score: 0.1642
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.002942
    • TAT(Tat/SPI): 0.001268
    • LIPO(Sec/SPII): 0.000387
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: QBF68849 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSFDGFFLHHIVEELRSELVNGRIQKINQPFEQELVLQIRSNRQSHRLLLSAHPVFGRIQLTQTTFENPAQPSTFIMVLRKYLQGALIESIEQVENDRIVEITVSNKNEIGDHIQATLIIEIMGKHSNILLVDKSSHKILEVIKHVGFSQNSYRTLLPGSTYIAPPSTKSLNPFTIKDEKLFEILQTQELTAKNLQSLFQGLGRDTANELERILVSEKLSAFRNFFNQETKPCLTETSFSPVPFANQVGEPFANLSDLLDTYYKDKAERDRVKQQASELIRRVENELQKNRHKLKKQEKELLATDNAEEFRQKGELLTTFLHQVPNDQDQVILDNYYTNQPIMIALDKALTPNQNAQRYFKRYQKLKEAVKYLTDLIEETKATILYLESVETVLNQAGLEEIAEIREELIQTGFIRRRQREKIQKRKKLEQYLASDGKTIIYVGRNNLQNEELTFKMARKEELWFHAKDIPGSHVVISGNLDPSDAVKTDAAELAAYFSQGRLSNLVQVDMIEVKKLNKPTGGKPGFVTYTGQKTLRVTPDSKKIASMKKS

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

A R Holmes, R McNab, K W Millsap, M Rohde, S Hammerschmidt, J L Mawdsley, H F Jenkinson
The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence.
Mol Microbiol: 2001, 41(6);1395-408
[PubMed:11580843] [WorldCat.org] [DOI] (P p)Daniela Pracht, Christine Elm, Joachim Gerber, Simone Bergmann, Manfred Rohde, Marleen Seiler, Kwang S Kim, Howard F Jenkinson, Roland Nau, Sven Hammerschmidt
PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation.
Infect Immun: 2005, 73(5);2680-9
[PubMed:15845469] [WorldCat.org] [DOI] (P p)Nadja Noske, Ulrike Kämmerer, Manfred Rohde, Sven Hammerschmidt
Pneumococcal interaction with human dendritic cells: phagocytosis, survival, and induced adaptive immune response are manipulated by PavA.
J Immunol: 2009, 183(3);1952-63
[PubMed:19570831] [WorldCat.org] [DOI] (I p)A Kadioglu, H Brewin, T Härtel, J L Brittan, M Klein, S Hammerschmidt, H F Jenkinson
Pneumococcal protein PavA is important for nasopharyngeal carriage and development of sepsis.
Mol Oral Microbiol: 2010, 25(1);50-60
[PubMed:20331793] [WorldCat.org] [DOI] (I p)Sajida Kanwal, Inga Jensch, Gottfried J Palm, Mark Brönstrup, Manfred Rohde, Thomas P Kohler, Daniela Somplatzki, Werner Tegge, Howard F Jenkinson, Sven Hammerschmidt
Mapping the recognition domains of pneumococcal fibronectin-binding proteins PavA and PavB demonstrates a common pattern of molecular interactions with fibronectin type III repeats.
Mol Microbiol: 2017, 105(6);839-859
[PubMed:28657670] [WorldCat.org] [DOI] (I p)Kartik Manne, Sthanam V L Narayana, Debasish Chattopadhyay
Crystal structure of the N-terminal domain of the fibronectin-binding protein PavA from Streptococcus pneumoniae.
Acta Crystallogr F Struct Biol Commun: 2019, 75(Pt 10);657-662
[PubMed:31584015] [WorldCat.org] [DOI] (I p)

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