PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

⊟Summary

• pan ID^?: PNEUPAN002295000
• symbol^?: zmpA
• synonym: iga
• description^?: immunoglobulin A1 protease

  descriptions from strain specific annotations:

  • immunoglobulin A1 protease
  • IgA-protease
  • ZmpA/ZmpB/ZmpC family metallo-endopeptidase
  • zinc metalloprotease A
  • IgA1 protease
  • immunoglobulin A1 protease precursor
  • pseudogene
• strand^?: +
• coordinates^?: 2864826..2879075
• occurrence^?: in 51% of 43 strains

⊟Orthologs

(4)^?
TIGR4:
SP_RS05695 (iga)
(2)
D39:
SPD_RS05470 (iga)
(2)
D39V:
—
(19A)
Hungary19A-6:
—
(19F)
EF3030:
—
(6B)^?
670-6B:
—
(6A)
6A-10:
HKM25_RS05430 (iga)
(5)
70585:
SP70585_RS06015 (iga)
(19F)
A026:
—
(3)
A66:
A66_RS05195
(11A)
AP200:
—
(12F)
ASP0581:
—
(19F)
ATCC 49619:
—
(23F)
ATCC 700669:
SPN23F_RS05375 (zmpA)
(19F)
BM6001:
—
(1)
BVJ1JL:
JN057_RS05775 (zmpA)
(14)
CGSP14:
—
(19F)
G54:
—
(1)
gamPNI0373:
—
(3)
HU-OH:
EL271_RS05455
(19A)
Hu15:
—
(19A)
Hu17:
—
(1)
INV104:
INV104_RS05770 (iga)
(14)
INV200:
—
(14)
JJA:
SPJ_RS05365 (zmpA)
(19F)
MDRSPN001:
—
(1)
NCTC7465:
AT689_RS08175 (zmpA)
(2)
NCTC7466:
—
(4)
NU83127:
EL277_RS05710 (iga)
(3)
OXC141:
SPNOXC_RS05605
(1)
P1031:
SPP_RS05660 (zmpA)
(2)
R6:
SPR_RS05200 (iga)
(19A)
SP49:
—
(1)
SPN032672:
SPN032672_RS00640 (iga)
(3)
SPN034156:
SPN034156_RS00660
(3)
SPN034183:
SPN034183_RS05620
(3)
SPN994038:
SPN994038_RS05525
(3)
SPN994039:
SPN994039_RS05530
(3)
SPNA45:
SPNA45_RS07995
(19F)
ST556:
—
(19F)
Taiwan19F-14:
—
(19A)
TCH8431/19A:
—
(4)
Xen35:
CXP32_RS05745 (iga)

⊟Genome Viewer

TIGR4
D39

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
  
  
  TIGR4           MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSS
  D39             MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSS
                  ************************************************************
  
  TIGR4           EEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAAMGIL
  D39             EEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAALGIL
                  ********************************************************:***
  
  TIGR4           IFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEI
  D39             IFAVSKKKVKNKTVLHLVLVAGMGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEI
                  **********************:*************************************
  
  TIGR4           SGYTYIGYIKEGKTTSESEVSNQKSSVATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPV
  D39             SGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPV
                  ****************: *****:.*.*********************************
  
  TIGR4           SSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNT
  D39             SSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNT
                  ************************************************************
  
  TIGR4           LNPQDEVLSGQLNKPELLYREETMETKIDFQEEIQENPDLAEGTVRVKQEGKLGKKVEIV
  D39             LNPQDEVLSGQLNKPELLYREETIETKIDFQEEIQENPDLAEGTVRVKQEGKLGKKVEIV
                  ***********************:************************************
  
  TIGR4           RIFSVNKEEVSREIVSTSTTAPSPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAI
  D39             RIFSVNKEEVSREIVSTSTTAPSPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAI
                  ************************************************************
  
  TIGR4           QPELPEAVVSDKGEPEVQPTLPEAVVTDKGETEVQPESPDTVVSDKGEPEQVAPLPEYKG
  D39             QPELPEAVVSDKGEPEVQPTLPEAVVTDKGETEVQPESPDTVVSDKGEPEQVAPLPEYKG
                  ************************************************************
  
  TIGR4           NIEQVKPETPVEKTKEQGPEKTEEVPVKPTEETPVNPNEGTTEGTSIQEAENPVQPAEES
  D39             NIEQVKPETPVEKTKEQGPEKTEEVPVKPTEETPVNPNEGTTEGTSIQEAENPVQPAEES
                  ************************************************************
  
  TIGR4           TTNSEKVSPDTSSKNTGEVSSNPSDSTTSVGESNKPEHNDSKNENSEKTVEEVPVNPNEG
  D39             TTNSEKVSPDTSSENTGEVSSNPSDSTTSVGESNKPEHNDSKNENSEKTVEEVPVNPNEG
                  *************:**********************************************
  
  TIGR4           TVEGTSNQETEKPVQPAEETQTNSGKIANENTGEVSNKPSDSKPPVEESNQPEKNGTATK
  D39             TVEGTSNQETEKPVQPAEETQTNSGKIANENTGEVSNKPSDSKPPVEESNQPEKNGTATK
                  ************************************************************
  
  TIGR4           PENSGNTTSENGQTEPEPSNGNSTEDVSTESNTSNSNGNEEIKQENELDPDKKVEEPEKT
  D39             PENSGNTTSENGQT-----------------------------------------EPEKK
                  **************                                         ****.
  
  TIGR4           LELRNVSDLELYSLSNGTYKQHISLEQVPSNPNSYFVKVKSSSFKDVYLPVASISEERKN
  D39             LELRNVSDIELYSQTNGTYRQHVSLDGIPENTDTYFVKVKSSAFKDVYIPVASITEEKRN
                  ********:**** :****:**:**: :*.*.::********:*****:*****:**::*
  
  TIGR4           DKILYKITAKVEKLQQEIESRYKDNFTFYLAKKGTEETTNFTSFSNLVKAINQNPSGTYH
  D39             GQSVYKITAKAEKLQQELENKYVDNFTFYLDKKAKEENTNFTSFSNLVKAINQNPSGTYH
                  .: :******.******:*.:* ******* **..**.**********************
  
  TIGR4           LAASLNANEVELGPDERSYIKDTFTGRLIGEKDGKNYAIYNLKKPLFENLSGATVEKLSL
  D39             LAASLNANEVELGPDERSYIKDTFTGRLIGEKDGKNYAIYNLKKPLFENLSGATVEKLSL
                  ************************************************************
  
  TIGR4           KNVAISGKDDIGSLANEAQNNTKIKQVHVDGVLAGERGIGGLLAKAEQSSITESSFKGRI
  D39             KNVAISGKNDIGSLANEATNGTKIKQVHVDGVLAGERGVGGLLAKADQSSIAESSFKGRI
                  ********:********* *.*****************:*******:****:********
  
  TIGR4           INTYETTAAYNIGGMVGHLTGDKALLTKSKATVAISSNTNTSDQTVGGLAGLVDRDAQIQ
  D39             VNTYETTDAYNIGGLVGHLTGKNASIAKSKATVTISSNTNRSDQTVGGLAGLVDQDAHIQ
                  :****** ******:******.:* ::******:****** *************:**:**
  
  TIGR4           DSYAEGDINNVKHFGRVAGVAGNLWDRTSGDVRHAGSLTNVLSDVNVTNGNAITGYHYNE
  D39             NSYAEGDINNVKHFGKVAGVAGYLWDRTSGEEKHAGELTNVLSDVNVTNGNAITGYHYTG
                  :**************:****** *******: :***.*********************. 
  
  TIGR4           MKVKDTFSSKANRVYNVTLVKDEVVSKESFEERGTMLDASQIASKKAEINPLILPTVEPL
  D39             MKVANTFSSKANRVFNVTLEKDEVVSKESFEERGTMLDASQIVSKKAEINPLTLPTVEPL
                  *** :*********:**** **********************.********* *******
  
  TIGR4           STSGKKDSDFSKVAYYQAKRNLTYKNIEKLLPFYNKATIVKYGNLVNENSLLYQKELLSA
  D39             STSGKKDSDFSKIAHYQANRALVYKNIEKLLPFYNKSTIVKYGNLVKENSLLYQKELLSA
                  ************:*:***:* *.*************:*********:*************
  
  TIGR4           VMMKDNQVITDIVSNKQTANKLLLHYKDDLSEKLDLKYQNDFAKLAEYSLGNTGLLYTPN
  D39             VMMKDDQVITDIVSNKQTANKLLLHYNDHSSEKFDLKYQTDFANLAEYNLGNTGLLYTPN
                  *****:********************:*. ***:*****.***:****.***********
  
  TIGR4           QFLYDQTSIIKQVLPDLQKVDYHSEAIRKTLGISPNVKQTELYLEDQFAKTKQQLEDSLK
  D39             QFLYDRDSIVKEVLPELQKLDYQSDAIRKTLGISPEVKLTELYLEDQFSKTKQNLGDSLK
                  *****: **:*:***:***:**:*:**********:** *********:****:* ****
  
  TIGR4           KLLSADAGLASANPVTEGYLVDKIKRNKEALLLGLTYLERWYNFSYGQVNVKDLVLYHLD
  D39             KLLSADAGLASDNSVTRGYLVDKIKNNKEALLLGLTYLERWYNFNYGQVNVKDLVMYHPD
                  *********** *.**.********.******************.**********:** *
  
  TIGR4           FFGKGNASPLDTLIELGKSGFNNLLAKNNVDTYGISLASQHGTTDLFSTLEHYRKVFLPN
  D39             FFGKGNTSPLDTLIELGKSGFNNLLAKNNVDTYGISLASQHGATDLFSTLEHYRKVFLPN
                  ******:***********************************:*****************
  
  TIGR4           TSNNDWFKSETKAYIVEEKSTIEEVKTKQGLAGTKYSIGVYDRITSATWKYRNMVLPLLT
  D39             TSNNDWFKSETKAYIVEEKSTIEEVKTKQGLAGTKYSIGVYDRITSATWKYRNMVLPLLT
                  ************************************************************
  
  TIGR4           LPERSVFVISTMSSLGFGAYDRYRSSDHKAGKALNDFVEENARETAKRQRDHYDYWYRIL
  D39             LPERSVFVISTMSSLGFGAYDRYRSSDHKAGKALNDFVEENARETAKRQRDHYDYWYRIL
                  ************************************************************
  
  TIGR4           DDNAREKLYRNILLYDAYKFGDDNTVGKATEVADFDNPNPAMQHFFGPVGNKVGHNQHGA
  D39             DEQSREKLYRTILLYDAYKFGDDTTSGKATAEAKFDSSNPAMKNFFGPVGNKVVHNQHGA
                  *:::******.************.* ****  *.**..****::********* ******
  
  TIGR4           YATGDAVYYMGYRMLDKDGAITYTHEMTHDSDQDIYLGGYGRRSGLGPEFFAKGLLQAPD
  D39             YATGDGVYYMSYRMLDKDGAITYTHEMTHDSDQDIYLGGYGRRNGLGPEFFAKGLLQAPD
                  *****.****.********************************.****************
  
  TIGR4           HPDDATITINSILKHSKSDSTESRRLQVLDPTTRFNNADDLKQYVHNMFDVVYMLEYLEG
  D39             QPSDATITINSILKHSKSDSTEGSRLQVLDPTERFQNAADLQNYVHNMFDLIYMMEYLEG
                  :*.*******************. ******** **:** **::*******::**:*****
  
  TIGR4           NSIL-KLDTNQKQQLLRKVTNEYHPDP-DGNKVYATNVVRNLTVEEVERLRSFNDLIDNN
  D39             QSIVNKLSVYQKMAALRKIENKYVKDPADGNEVYATNVVKELTEAEARNLNSFESLIDHN
                  :**: **.. **   ***: *:*  ** ***:*******::**  *...*.**:.***:*
  
  TIGR4           ILSSREYASGKYERNGYFTIKLFAPIYAALSNDIGTPGDLMGRRIAYELLAAKGFKDGMV
  D39             ILSAREYQSGDYERNGYYTIKLFAPIYSALSSEKGTPGDLMGRRIAYELLAAKGFKDGMV
                  ***:*** **.******:*********:***.: **************************
  
  TIGR4           PYISNQYEEEAKQKGKTINLYGKTRGLVTDDLVLEKVFNNQYHTWSEFKKAMYQERQDQF
  D39             PYISNQYEEDAKQQGQTINLYGKERGLVTDELVLKKVFDGKYKTWAEFKTAMYQERVDQF
                  *********:***:*:******* ******:***:***:.:*:**:***.****** ***
  
  TIGR4           DRLNKVTFNDTTQPWQTFAKKTTSSVDELQKLMDVAVRKDAEHNYYHWNNYNPDIDSEVH
  D39             GNLKQVTFKDPTKPWPSYGTKTINNVDELQALMDQAVLKDAEGP--RWSNYDPEIDSAVH
                  ..*::***:*.*:** ::..** ..***** *** ** ****    :*.**:*:*** **
  
  TIGR4           KLKRAIFKAYLDQTNDFRSSIFENKK
  D39             KLKRAIFKAYLDQTNDFRSSIFENKK
                  **************************