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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BM6001serotype 19F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7465serotype 1
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 17-DEC-2024
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae A66
- locus tag: A66_RS05195 [old locus tag: A66_01038 ]
- pan locus tag?: PNEUPAN002295000
- symbol: A66_RS05195
- pan gene symbol?: zmpA
- synonym: iga
- product: ZmpA/ZmpB/ZmpC family metallo-endopeptidase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS, pseudogene
- locus tag: A66_RS05195 [old locus tag: A66_01038 ]
- symbol: A66_RS05195
- product: ZmpA/ZmpB/ZmpC family metallo-endopeptidase
- replicon: chromosome
- strand: +
- coordinates: 997874..1003698
- length: 5825
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NZ_LN847353 (997874..1003698) NCBI
- BioCyc:
- MicrobesOnline:
- PneumoBrowse for strain D39V:
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1981
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5821ATGGAAAAGTATTTTGGTGAAAAACAAGAGCGTTTTTCATTTAGAAAATTATCAGTAGGA
CTTGTATCTGCAACGATTTCAAGTTTATTTTTTATGTCTGTATTAGCTAGTTCATCTGTG
GATGCTCAAGAAACTGCGGGAGTTCACTATAAATATGTGGCAGATTCAGAGCTATCATCA
GAAGAAAAGAAGCAGCTTGTCTATGATATTCCGACATACGTGGAGAATGATGATGAAACT
TATTATCTTGTTTATAAGTTAAATTCTCAAAATCAACTGGCGGAATTACCAAATACTGGA
AGCAAGAATGAGAGGCAAGCCCTAGTTGCTGGTGCTAGCTTAGCTGCTCTGGGAATTTTA
ATTTTTGCTGTTTCCAAGAAAAAGGTTAAGAATAAAACGGTATTACATTTAGTATTGGTT
GCGGGAATAGGAAATGGTGTCTTAGTTTCAGTCCATGCTTTAGAAAATCATCTTTTGCTA
AATTACAATACGGACTATGAATTGACCTCTGGAGAAAAATTACCTCTTCCTAAAGAGATT
TCAGGTTACACTTATATTGGATATATCAAAGAGGGAAAAACGACTTCTGATTTTGAAGTA
AGTAATCAAGAAAAATCAGCAGCCACTCCTACAAAACAACAAAAGGTGGATTATAATGTT
ACACCAAATTTTGTAGACCATCCATCAACAGTACAAGCTATTCAGGAACAAACACCTGTT
TCTTCAACTAAGCCGACAGAAGTTCAAGTAGTTGAAAAACCTTTCTCTACTGAATTAATC
AATCCAAGAAAAGAAGAGAAACAATCTTCAGATTCTCAAGAACAATTAGCCGAACATAAG
AATCTAGAAACGAAGAAAGAGGAGAAGATTTCTCCAAAAGAAAAGACTGGGGTAAATACA
TTAAATCCACAGGATGAAGTTTTATCAGGTCAATTGAACAAACCTGAACTCTTATATCGT
GAGGAAACTATAGAGACAAAAATAGATTTTCAAGAAGAAATTCAAGAAAATCCTGATTTA
GCTGAAGGAACTGTAAGAGTAAAACAAGAAGGTAAATTAGGTAAGAAAGTTGAAATCGTC
AGAATATTCTCTGTAAACAAGGAAGAAGTTTCGCGAGAAATTGTTTCAACTTCAACGACT
GCGCCTATTCCAAGAATAGTCGAAAAAGGTACTAAAAAAACTCAAGTTATAAAGGAACAA
CCTGAGACTGGTGTAGAACATAAGGACGTACAGTCTGGAGCTATTGTTGAACCCGCAATT
CAGCCTGAGTTGCCAGAAGCAGTAGTAAGTGATAAAGGTGAACCAGAGCAGGTAGCCCCA
TTGCCAGAATATAAGGGTAATATTGAGCAAGTAAAACCTGAAACTCCGGTTGAGAAGACC
AAAGAACAAGGTCCAGAAAAAACTGAAGAAGTTCCAATAAAACCAACAGAAGAAACACCA
GTAAATCCAAATGAAGGTACTACAGAAGGAACCTCAATTCAAGAAGCAGAAAATCCAGTT
CAACCTGCAGAAGAATCAACAACGAATTCAGAGAAAGTATCACCAGATACATCTAGCGAA
AATACTGGGGAAGTGTCCAGTAATCCTAGTGATTCGACAACCTCAGTTGGAGAATCAAAT
AAACCAGAACATAATGACTCTAAAAATGAAAATTCAGAAAAAACTGGAGAAGAAGTTCCA
GTAAATCCAAATGAAGGCACAGTAGAAGGTACCTCAAATCAAGAAACAGAAACACCAGTT
CAACCTGCAGAAGAAACACAAACAAACTCTGGGAAAATAGCTAACGAAAATACTGGAGAA
GTATCCAATAAACCTAGTGATTCAAAACCACCAGTTGAAGAATCAAATCAACCAGAAAAT
TCAGGTAATACAACATCAGAGAATGGACAAACAGAACCAGAACCATCAAACGGAAATTCA
ACTGAGGATGTTTCAACCGAATCAAACACATACAATTCAAATGGAAATGAAGAAATTAAA
CAAGAAAATGAACTAGACCCTGATAAAAAGGTAGAAGAACCAGAGAAAACACTTGAATTA
AGAAATGTGTCAGAAATTGAATTGTACAGTGTGACAGATAACGTGTATAAACAGCAAGTG
TTTTTAGAGAAGCTTCCAAGTAATATCGATAGATTCTTTGTAAAAGTAAAATCGACCACC
ATTAAAGATGTCTATCTACCAGTAGAATCAATTGTGGAAGAAACTAAAGATGGTAAGCAA
GTTTATAAAATCACAGCAAAAGTAGAGAAGCTTCAGCAGGAGATAGAAAGTAGATATAAA
GATAATTTTACCTTCTATCTAGCTAAGAAGGGAACAGAAGAAACAACAAACTTTACTTCC
TTTAGTAATCTGGTCAAAGCTATAAACCAAAATCTCTCTGGAACCTATCATTTAGGAGCT
AGCCTGAATGCTAACGAAGTGGAGCTTAGTACTGATGATAAATCCTATATCAAGGGAACC
TTTACTGGTCAGTTGATTGGTGAAAAAGATGGTAAGCATTATGCTATTTACAACTTGAAA
AAGCCTCTTTTTGAAAGCTTGAGAGGGGCCACAATAGAAAAGTTGAGTCTGAAAAATGTA
TCTATTTCAGGGAAAGATGATATCGGTTCACTGGCAAATGAAGCTAAAAATGGAACAACC
ATTAATGAAGTTCATGTTGACGGTCTCTTAGGAGGTGAACGTGGTATTGGTGGTTTAGTG
GCTAAAGTGGATCAATCCAATATCACAAATAGTAGTTTTACTGGAAGAATTGTTAATACT
TATGAAACAACTGCTTCCTATAATATCGGCGGCCTGGTCGGTCATTTGACAGGAAGCAAA
GCTTCACTGACTAAGTCAAAAGCGACAGTGGTCATTTCATCAAATACAAATAGTTCTGAC
CAGACCGTTGGAGGTATCGCTGGTCTTGTAGACAAAGATGCGCATATTCAGAATAGCTAT
TCTGAAGGGGATATTAATAATAGCCAACGTTTTGGAAAAGTTGCTGGTATAGCAGGTAAC
TTATGGGATCGTGAATCAAATAGTGAAAATCATGCTGGAAGATTGACTAATGTGCTTAGT
GGTGTCAATGTAACTAATGGAAATGCCATTAGTAGTTACCATTATAATGGAATGAAAATT
ACTGATGCATTTAGTAATAAAGCGAATAAAGTTTTCAATGTCACTTTAGAGAAGGATGAG
GTCGTCAGCAAAGAATCCTTTGAGGAAAGAGGAACAATGCTAGATGCTTCTCAAATTGCA
AGCAAAAAAGCAGAAATCAATCTTCTCACTCCACCAATAGTGGAACCCCTCTCAACAAGC
GGTAAGAAAGACAGTGATTTTTCTAAGATAGCCCATTATCAAGCCAACCGTGCTTTGGTT
TATAAGAACATTGAAAAATTGTTACCTTTCTATAACAAGGCGACCATCGTGAAATACGGA
AACCTGGTTAAGGAGAACAGTATCTTATATCAAAAAGAACTCTTGTCTGCAGTTATGATG
AAGGATGACCAAGTAATCACAGATATTATTTCCAACAAACAGACTGCAAACAAACTCTTG
CTTCACTACAAGGACCATTCATCTGAAAAGTTTGATCTCAGGTACCAGGATGATTTTGCC
AATTTGGCAGAATATAGCATTGGAGATAGTGGGCTTCTCTATACGCCAAATCAATTCTTG
TATGACCAAGACTCTATCATCAATCAAGTTTTACCTGAATTACAGCAGGTTGCCTACGAT
TCAGAAGCTATCAGAAAGACACTCGGAATTTCTCCAGAGGTCAAGCAAACTGAGCTCTAT
ATGGAAGACCAGTTTACCAAAACAAAGCAAGATTTGGCAAACAGTTTGAAAAAACTCTTG
TCTGCAGATGCTGGACTTGCTGGTGACAACCCAGTTACCAGAGGCTATCTTAACGTTGGT
ATAACTTTAGCTATGGTCAGGTGAATGTCAAAGACCTAGTTATGTATCATCCGGACTTCT
TTGGTAAAGGAAATACTTCACCATTAGATACTCTGATTGAGTTAGGTAAATCTGGCTTTA
ACAATCTTCTTGCTAAAAACAATATCGATACTTATGCTATCAGCCTTGCCAGCCATCATG
GAACGACAGATTTGTTTAGCACGTTGGAAAATTACCGAAAAGTCTTTCTACCAGACAAAA
CCAATAATAACTGGTTTAAATCACAGACTAAGGCTTACATTGTCGAAGAAAAATCCAATA
TCGAAGAGGTGAAAACGAAGCAAGGACTAGTTGGCACTAAGTATTCTATTGGTGTCTATG
ACCGTATCACTAGTGCTACATGGAAATACCGCAATATGGTCTTGCCGCTCCTAACCTTGC
CGGAGAAATCAGTCTTTGTCATCTCGACCATCTCTAGTCTAGGATTTGGAGCTTATGATC
GTTACCGCAATAGTGAGCACAAAGCAGGCAAGGACCTCAATGATTTTGTTGAAGAAAATG
CACGTGAAACAGCCAAACGTCAGCGAGATCACTACGATTATTGGTATCGTATTTTAGACG
ACAATGCACGTGAAAAACTTTATAGAAATATTTTGCTTTACGATGCTTATAAATTTGGCG
ATGATAATACCGTAGGGAAAGCTACAGAAGTGGCAGATTTTGATAATCCAAATCCTGCAA
TGCAACATTTCTTTGGACCTGTTGGAAATAAAGTTGGGCATAATCAACACGGTGCTTATG
CTACAGGTGATGCAGTTTATTATATGGGTTATCGAATGTTGGATAAGGATGGAGCTATTA
CTTATACGCATGAGATGACACATGACTCAGATCAGGACATTTATCTTGGAGGATATGGTC
GAAGAAGTGGCTTGGGACCAGAGTTCTTTGCTAAAGGATTATTACAAGCACCAGACCATC
CAGATGATGCGACCATTACCATCAACTCCATCTTGAAACATTCAAAATCTGATAGTACAG
AAAGTCGACGATTACAAGTACTTGATCCAACTACAAGATTTAATAATGCAGATGATTTGA
AGCAATATGTCCACAACATGTTTGACGTTGTTTATATGTTGGAATATCTCGAAGGAAATT
CAATTCTTAAATTGGATACGAATCAAAAACAACAACTTCTTAGAAAAGTTACAAATGAGT
ACCATCCTGATCCTGATGGAAATAAGGTCTATGCAACAAATGTTGTCAGAAATCTAACAG
TAGAAGAAGTTGAAAGACTACGTTCATTCAATGATTTGATTGATAATAATATTCTTTCGT
CTAGGGAATATGCCTCAGGTAAATACGAAAGAAATGGCTATTTCACTATTAAATTATTTG
CGCCGATTTATGCAGCATTAAGTAATGATGACGGAACGCCAGGTGATCTGATGGGACGTC
GTATGGCCTATGAACTATTAGCTGCAAAAGGCTTTAAAGATGGTATGGTGCCATATATCT
CAAATCAATTTGAAGCAGATGCTAGGGCAAATAATAAAACGATTACCTCATATGGTAAGA
CCAAAGGATTAGTAACAGATACATTAGTTCTTCAAAAATTATTTAATGGACAATACAATA
CCTGGAGTGATTTTAAGAAAGCTATGTATAAAGAACGTCAGGATAAATTCAATAAATTGA
ACAAAATTTCATTTAAAGATCCGTCTCAACCTTGGACGCGCAATATTATTAAGACAATTC
ACAGTGTAAATGAACTGCAGAACTTAATGAATGAAGCTGTCCGCAAGGATACAGAAACTC
CTCATTGGTATAACTATAATCCAGAAATAGACAGTGCAGTTCATAAGTTGAAGAGAGCAA
TCTTTAAAGCCTATCTTGACCAAACAAATGATTTTAGAAGTTCAATTTTTGAGAATAAAA
AATAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: A66_RS05195 [old locus tag: A66_01038 ]
- symbol: A66_RS05195
- description: ZmpA/ZmpB/ZmpC family metallo-endopeptidase
- length:
- theoretical pI:
- theoretical MW:
- GRAVY:
⊟Function[edit | edit source]
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb:
- DeepLocPro:
- SignalP:
- predicted transmembrane helices (TMHMM):
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: see A66_01038
- UniProt:
⊟Protein sequence[edit | edit source]
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V:
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Jeffrey N Weiser, Deborah Bae, Claudine Fasching, Ronald W Scamurra, Adam J Ratner, Edward N Janoff
Antibody-enhanced pneumococcal adherence requires IgA1 protease.
Proc Natl Acad Sci U S A: 2003, 100(7);4215-20
[PubMed:12642661] [WorldCat.org] [DOI] (P p)Damiana Chiavolini, Guido Memmi, Tiziana Maggi, Francesco Iannelli, Gianni Pozzi, Marco R Oggioni
The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.
BMC Microbiol: 2003, 3;14
[PubMed:12841855] [WorldCat.org] [DOI] (I e)E N Janoff, J B Rubins, C Fasching, D Charboneau, J T Rahkola, A G Plaut, J N Weiser
Pneumococcal IgA1 protease subverts specific protection by human IgA1.
Mucosal Immunol: 2014, 7(2);249-56
[PubMed:23820749] [WorldCat.org] [DOI] (I p)H Lomholt
Evidence of recombination and an antigenically diverse immunoglobulin A1 protease among strains of Streptococcus pneumoniae.
Infect Immun: 1995, 63(11);4238-43
[PubMed:7591053] [WorldCat.org] [DOI] (P p)K Poulsen, J Reinholdt, M Kilian
Characterization of the Streptococcus pneumoniae immunoglobulin A1 protease gene (iga) and its translation product.
Infect Immun: 1996, 64(10);3957-66
[PubMed:8926055] [WorldCat.org] [DOI] (P p)J H Wani, J V Gilbert, A G Plaut, J N Weiser
Identification, cloning, and sequencing of the immunoglobulin A1 protease gene of Streptococcus pneumoniae.
Infect Immun: 1996, 64(10);3967-74
[PubMed:8926056] [WorldCat.org] [DOI] (P p)