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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 02-MAY-2018

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae D39
  • locus tag: SPD_0280 [new locus tag: SPD_RS01530 ]
  • pan locus tag?: PNEUPAN001093000
  • symbol: SPD_0280
  • pan gene symbol?: celR
  • synonym:
  • product: transcriptional regulator, putative

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPD_0280 [new locus tag: SPD_RS01530 ]
  • symbol: SPD_0280
  • product: transcriptional regulator, putative
  • replicon: chromosome
  • strand: +
  • coordinates: 276844..278817
  • length: 1974
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    GTGTTAAACATTAAAGAGAAAGATATCCTTCAATTTTTAATAAAAAATAAGGAACGTTTT
    GTTACAAGCAAAGAACTGGCAGAATATTTATCCTGTTCAGATAGAACTGTCCGTAATGTA
    CTGAAATTAATTGAGAAGACAATGATTATTCAAGGAGTCCGGTTGATTTCAAAACAAGGT
    CAAGGGTATCAAATATTTTTTGAGAATCAAGGCGCTTATCAAGAGTTTAGACAAACTTAT
    GAACTGGCAGAAGACTATACGAAAACTGCGGTTTCAAAAGGTGATGATCGTTTAGTATTT
    ATCTTAAATAAATTATTATTTGAGCAAGTTCCAGTTCTTTTTGATGATTTAGCTGATGAA
    CTTTACGTTAGTCGTTCAACATTATCTCATGATTTCAAAAAGATACGAGTGATGTTATCA
    GAGTATAATTTGTCCATTGAGAGTAGGGCGAATAAAGGAGTTTATGTCTCAGGCGAGGAA
    CGTGATAAACGACGTTTTATCATAAATTATTTCCTAGAGAATCAATTTTTTAAAACAATA
    CATTGCTATGTAAAATTTAACTTTTTTGATCAAACTGTTCCATTAGAAGAATTTGCTAGA
    ATTGTTTTGGATGAATGCCAAGAGGCCAACCTAAAACTATCTGATTTTGTACTACAGAAT
    TTAGTAGTTCACATAGCATTGTCTGTGATTCGTTTAAAATCCGGATTTGAAATAAAAAAT
    ATAGACTGTCAGATGACTGATGATGCAATAGAGAGAAAGGTTGCCCAAAGAATTCTTTCT
    AAAGTAAGAGAAGTAACAAATCAGGAATTTCCAGTTCAGGAAATAGACTACATTACTTTG
    CATTTGTTAGCTAAGAGTCAACAATGTCAAAAAAATCAGAAGAATATTTCTGAAGAAGTT
    TTAAAAAAATCTTTACTTAAAACATTTCAGAATTTAGGATTAGATGATATGTATAACTTT
    TCTTCAGATTTCCAACTAATTGAAGGATTGATAACTCATCTAATGACACTACAAGTACGT
    TTAGAAAGCCGGATTACCTTAAATAACCCTTTGGTAGATGAAATTAAACAGAATTATAGT
    GATATATTCTTTATGACTAGAGAAATTCTTGCAAATATGGACAAGTTCTTGGAGTGGTCA
    ATATCAGATGATGAAATAGCATATGTAAGTCTTCACTTTTTAGCTGCTATGGAACGTAGC
    AAAGAGAGTACTAAGTTTAATATTCTTGCTATTTGTGCAACGGGATTTGGTGCAGCCCAA
    ATGTTAAGAAATCGTTTGGAAACGGAGTTTGGGAACCGAGTAGAAGTTGTTGATGTAATA
    GGCTATTATGAATTGAATCAAGAAAAACTTAAAGGAATAGATTTTATAGTGTCGGCTGTT
    GATTTATCAAATCTATATTTTCAAATTCCAGTTTTTAAAGTTAGTGTATTTCTTAAGAGT
    GATGAGATGGAAATGATTCGCAAAGCTATGGATCAGATGCAAGTTTCAAGTCATATACAA
    TCGTCAAAGATTAGCAAGTTTGAAAACAACAACTTTAGACAGTATTTTAGTAAAGAAAAT
    TTTTTAATATGTACTAAATATGACAAGGAAAATTTACTTGAAAAGATGGTTGAGGGTTTA
    TCTGTTGGTGAATCAAATGAGTTTGAACAATCTTTACTTTATGGAATTAAACAGCGAGAA
    GAATTAAGTTCAGTTGTTTTTTCTGAAAAAATTGCAGTTCCGCATCCTATTCAACCCTTT
    GGTACAGAGGGAAAGGTTTCGATTGCAATTTGTAAAGATTCGTTACTCTGGGATAATCAA
    AGTTCACATGTCCAGCTAGTATTTCTTCTATCTCCATCAATATATGGGAACGAAGGTTTG
    GCAACTGTGACTAAAAAGATAGTCTCTCTGACAGAGAATGATGAATTGCAAAATCAGCTA
    ATATCTTGCAATAACTTTGAAGATTTTATTAACATATTTGAGAAGATAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1974

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPD_0280 [new locus tag: SPD_RS01530 ]
  • symbol: SPD_0280
  • description: transcriptional regulator, putative
  • length: 657
  • theoretical pI: 5.10743
  • theoretical MW: 76297.1
  • GRAVY: -0.204871

⊟Function[edit | edit source]

  • TIGRFAM:
    Metabolism Transport and binding proteins Carbohydrates, organic alcohols, and acids PTS system, fructose subfamily, IIA component (TIGR00848; EC 2.7.1.69; HMM-score: 36.7)
    Signal transduction Signal transduction PTS PTS system, fructose subfamily, IIA component (TIGR00848; EC 2.7.1.69; HMM-score: 36.7)
    and 4 more
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 14.1)
    Signal transduction Regulatory functions DNA interactions iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 14.1)
    Unknown function General DNA binding domain, excisionase family (TIGR01764; HMM-score: 14)
    Signal transduction Signal transduction PTS PTS IIA-like nitrogen-regulatory protein PtsN (TIGR01419; HMM-score: 13.4)
  • TheSEED  :
    • Transcriptional antiterminator of lichenan operon, BglG family
    Carbohydrates Di- and oligosaccharides Beta-Glucoside Metabolism  Transcriptional antiterminator of lichenan operon, BglG family
  • PFAM:
    PRD (CL0166) PRD; PRD domain (PF00874; HMM-score: 127.2)
    and 23 more
    HTH (CL0123) HTH_11; HTH domain (PF08279; HMM-score: 77.5)
    Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 50.1)
    PTase-anion_tr (CL0340) PTS_EIIA_2; Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 (PF00359; HMM-score: 49.9)
    Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 24.9)
    HTH (CL0123) HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 22)
    HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 18.9)
    HrcA_DNA-bdg; Winged helix-turn-helix transcription repressor, HrcA DNA-binding (PF03444; HMM-score: 17.8)
    SgrR_N; Sugar transport-related sRNA regulator N-term (PF12793; HMM-score: 17.1)
    HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 16.7)
    PuR_N; Bacterial purine repressor, N-terminal (PF09182; HMM-score: 16.4)
    MarR_2; MarR family (PF12802; HMM-score: 15.7)
    HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 15.6)
    HTH_AraC; Bacterial regulatory helix-turn-helix proteins, AraC family (PF00165; HMM-score: 15.3)
    HTH_10; HTH DNA binding domain (PF04967; HMM-score: 15.2)
    Phage_CI_repr; Bacteriophage CI repressor helix-turn-helix domain (PF07022; HMM-score: 15)
    Trans_reg_C; Transcriptional regulatory protein, C terminal (PF00486; HMM-score: 14.9)
    HTH_20; Helix-turn-helix domain (PF12840; HMM-score: 14.7)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 14)
    PH (CL0266) DM10_dom; DM10 domain (PF06565; HMM-score: 13)
    UBC (CL0208) Prok-E2_D; Prokaryotic E2 family D (PF14460; HMM-score: 13)
    HTH (CL0123) TFIIE_beta; TFIIE beta subunit core domain (PF02186; HMM-score: 12.3)
    Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 12.3)
    HTH_36; Helix-turn-helix domain (PF13730; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors: CelB, cellobiose-specific PTS component EIIB; HPr, phosphocarrier protein
  • genes regulated by CelR*, TF important in Cellobiose utilizationRegPrecise
    repression
    bglA-1
    celB* > celR* > celC* > SPD_0282 > celD*
    transcription units transferred from TIGR4 data RegPrecise

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.00385
    • TAT(Tat/SPI): 0.000227
    • LIPO(Sec/SPII): 0.00217
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MLNIKEKDILQFLIKNKERFVTSKELAEYLSCSDRTVRNVLKLIEKTMIIQGVRLISKQGQGYQIFFENQGAYQEFRQTYELAEDYTKTAVSKGDDRLVFILNKLLFEQVPVLFDDLADELYVSRSTLSHDFKKIRVMLSEYNLSIESRANKGVYVSGEERDKRRFIINYFLENQFFKTIHCYVKFNFFDQTVPLEEFARIVLDECQEANLKLSDFVLQNLVVHIALSVIRLKSGFEIKNIDCQMTDDAIERKVAQRILSKVREVTNQEFPVQEIDYITLHLLAKSQQCQKNQKNISEEVLKKSLLKTFQNLGLDDMYNFSSDFQLIEGLITHLMTLQVRLESRITLNNPLVDEIKQNYSDIFFMTREILANMDKFLEWSISDDEIAYVSLHFLAAMERSKESTKFNILAICATGFGAAQMLRNRLETEFGNRVEVVDVIGYYELNQEKLKGIDFIVSAVDLSNLYFQIPVFKVSVFLKSDEMEMIRKAMDQMQVSSHIQSSKISKFENNNFRQYFSKENFLICTKYDKENLLEKMVEGLSVGESNEFEQSLLYGIKQREELSSVVFSEKIAVPHPIQPFGTEGKVSIAICKDSLLWDNQSSHVQLVFLLSPSIYGNEGLATVTKKIVSLTENDELQNQLISCNNFEDFINIFEKIK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CelR* (repression) regulon, CcpA regulon
    CelR*(TF)important in Cellobiose utilization; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 
    CcpA(TF)important in Global catabolite repression; RegPrecise    transcription unit transferred from TIGR4 data RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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