⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae SPNA45
- locus tag: SPNA45_RS14355 [old locus tag: SPNA45_00270 ]
- pan locus tag?: PNEUPAN003528000
- symbol: SPNA45_RS14355
- pan gene symbol?: lytA
- synonym:
- product: thiol-activated cytolysin family protein
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS, pseudogene
- locus tag: SPNA45_RS14355 [old locus tag: SPNA45_00270 ]
- symbol: SPNA45_RS14355
- product: thiol-activated cytolysin family protein
- replicon: chromosome
- strand: +
- coordinates: 283940..>285148
- length: 1209
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_018594 (283940..>285148) NCBI
- BioCyc:
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_1737 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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1201ATGGAAATTAATGTGAGTAAATTAAGAACAGATTTGCCTCAAGTCGGCGTGCAACCATAT
AGGCAAGTACACGCACACTCAACTGGGAATCCGCATTCAACCGTACAGAATGAAGCGGAT
TATCACTGGCGGAAAGACCCATAATTAGGTTTTTTCTCGCACATTGTTGGGAACGGTTGC
ATCATGCAGGTAGGACCTGTTGATAATGGTGCCTGGGACGTTGGGGGCGGTTGGAATGCT
GAGACCTATGCAGCGGTTGAACTGATTGAAAGCCATTCAACTAAAGAAGAGTTCATGACG
GACTACCGCCTTTATATCGAACTCTTACGCAATCTAGCAGATGAAGCAGGTTTGCCGAAA
ACGCTTGATACAGGGAGTTTAGCTGGAATTAAAACGCACGAGTATTGCACGAATAACCAA
CCAAACAACCACTCAGACCATGTGGATCCATACCCTTACTTGGCAAAATGGGGCATTAGC
CGTGAGCAGTTTAAGCATGATATTGAGAACGGCTTGACGATTGAAACAGGCTGGCAGAAG
AATGACACTGGCTACTGGTACGTACATTCAGACGGCTCTTATCCAAAAGACAAGTTTGAA
AAAATCACGGCTCACAGCATGGAACAACTCAAGGTCAAGTTTGGTTCTGACTTTGAAAAG
ACAGGGAATTCTCTTGATATTGATTTTAACTCTGTCCATTCAGGCGAAAAGCAGATTCAG
ATTGTTAATTTTAAGCAGATTTATTATACAGTCAGCGTAGATGCTGTTAAAAATCCAGGA
GATGTGTTTCAAGATACTGTAACGGTAGAGGATTTAAAACAGAGAGGAATTTCTGCAGAG
CGTCCTTTGGTCTATATTTCGAGTGTTGCTTATGGGCGCCAAGTCTATCTCAAGTTGGAA
ACCACGAGTAAGAGTGATGAAGTAGAGGCTGCTTTTGAAGCTTTGATAAAAGGAGTCAAG
GTAGCTCCTCAGACAGAGTGGAAGCAGATTTTGGACAATACAGAAGTGAAGGCGGTTATT
TTAGGGGGCGACCCAAGTTCGGGTGCCCGAGTTGTAACAGGCAAGGTGGATATGGTAGAG
GACTTGATTCAAGAAGGCAGTCGCTTTACAGCAGATCATCCAGGCTTGCCGATTTCCTAT
ACAACTTCTTTTTTACGTGACAATGTAGTTGCGACCTTTCAAAACAGTACAGACTATGTT
GAGACTAAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPNA45_RS14355 [old locus tag: SPNA45_00270 ]
- symbol: SPNA45_RS14355
- description: thiol-activated cytolysin family protein
- length:
- theoretical pI:
- theoretical MW:
- GRAVY:
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM:
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb:
- DeepLocPro:
- SignalP:
- predicted transmembrane helices (TMHMM):
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: see SPNA45_00270
- UniProt:
⊟Protein sequence[edit | edit source]
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_1737 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
P García, M Paz González, E García, J L García, R López
The molecular characterization of the first autolytic lysozyme of Streptococcus pneumoniae reveals evolutionary mobile domains.
Mol Microbiol: 1999, 33(1);128-38
[PubMed:10411730] [WorldCat.org] [DOI] (P p)P Balachandran, S K Hollingshead, J C Paton, D E Briles
The autolytic enzyme LytA of Streptococcus pneumoniae is not responsible for releasing pneumolysin.
J Bacteriol: 2001, 183(10);3108-16
[PubMed:11325939] [WorldCat.org] [DOI] (P p)E Díaz, R López, J L García
Role of the major pneumococcal autolysin in the atypical response of a clinical isolate of Streptococcus pneumoniae.
J Bacteriol: 1992, 174(17);5508-15
[PubMed:1355082] [WorldCat.org] [DOI] (P p)Peter Mellroth, Robert Daniels, Alice Eberhardt, Daniel Rönnlund, Hans Blom, Jerker Widengren, Staffan Normark, Birgitta Henriques-Normark
LytA, major autolysin of Streptococcus pneumoniae, requires access to nascent peptidoglycan.
J Biol Chem: 2012, 287(14);11018-29
[PubMed:22334685] [WorldCat.org] [DOI] (I p)J V Höltje, A Tomasz
Specific recognition of choline residues in the cell wall teichoic acid by the N-acetylmuramyl-L-alanine amidase of Pneumococcus.
J Biol Chem: 1975, 250(15);6072-6
[PubMed:238995] [WorldCat.org] (P p)A M Berry, R A Lock, D Hansman, J C Paton
Contribution of autolysin to virulence of Streptococcus pneumoniae.
Infect Immun: 1989, 57(8);2324-30
[PubMed:2568343] [WorldCat.org] [DOI] (P p)J F Garcia-Bustos, A Tomasz
Teichoic acid-containing muropeptides from Streptococcus pneumoniae as substrates for the pneumococcal autolysin.
J Bacteriol: 1987, 169(2);447-53
[PubMed:2879828] [WorldCat.org] [DOI] (P p)A Tomasz, P Moreillon, G Pozzi
Insertional inactivation of the major autolysin gene of Streptococcus pneumoniae.
J Bacteriol: 1988, 170(12);5931-4
[PubMed:2903859] [WorldCat.org] [DOI] (P p)L V Howard, H Gooder
Specificity of the autolysin of Streptococcus (Diplococcus) pneumoniae.
J Bacteriol: 1974, 117(2);796-804
[PubMed:4149515] [WorldCat.org] [DOI] (P p)P Usobiaga, F J Medrano, M Gasset, J L Garciá, J L Saiz, G Rivas, J Laynez, M Menéndez
Structural organization of the major autolysin from Streptococcus pneumoniae.
J Biol Chem: 1996, 271(12);6832-8
[PubMed:8636107] [WorldCat.org] [DOI] (P p)