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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu15
  • locus tag: SPNHU15_RS10545 [old locus tag: SPNHU15_02229 ]
  • pan locus tag?: PNEUPAN003837000
  • symbol: pspC
  • pan gene symbol?: cbpA
  • synonym:
  • product: pneumococcal surface protein PspC, choline-binding form

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU15_RS10545 [old locus tag: SPNHU15_02229 ]
  • symbol: pspC
  • product: pneumococcal surface protein PspC, choline-binding form
  • replicon: chromosome
  • strand: -
  • coordinates: <2099863..2101486
  • length: 1624
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020551 <2099863..2101486 NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V:

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    ATGTTTGCATCAAAAAGCGAAAGAAAAGTACATTATTCAATTCGTAAATTTAGTATTGGA
    GTAGCTAGTGTAGTAGTTGCTAGCTTGTTCTTAGGAGGAGTAGTTCATGCAGAAGGGGTT
    AGAAGTGGGGATACCCCCAAGGTTACATCTAGTGGGGATGAAGTCGAGTCGCATCTAAAA
    AAAATATTGAGTGAGATCCAAACACAATTAGATAGAAAACGACATGCCAAAACTGTAGCG
    CTAATTAACAAGTTGCAAGACATTAAGAGAACGTATTCGTATAAATTAAATGTTTTAGAA
    GAGAAGCCGAAAGCTGAGTTGACGTCAAAAGCTAAAGCAGAGTTAGACGCAGCTTTTGAG
    CAGTTTAAAAAAGAACCAGAACTTACTAAAAAAGTAGCAGAAGCTCAGAAGAAGGTTGAA
    GAAGCTAAGAAAAAAGCCGAGGATCAAAAAGAAGAAGATTTCCGTAACTACCCAACCAAT
    ACTTACAAAACAATCGAACTTGAAATTGCTGAGTCCGATGTGAAAGTTAAAGAAGCGGAG
    CTTGAACTATTGAAAGAGGAAGCTAAGGAACATCGAGACGAGGGCACAATTAAGCAAGTA
    GAAGAGAAAGTTAAGAGTGAAAAAGCTGAGGCTACAAGGTTAGAAGAAATCAAGACAGAT
    CGTGAAGAAGCTAAACGAAAAGCAGATGCTAAGTTGAAGGAAGCTGTTGAAAAGAATGTA
    GCGACTTCAGAGCAAGATAAACTAAAGGGGCGGAGAAAACGAGGAGTTCTTGGAGAGCCA
    GCAACACCTGATAAAAAAGAAAATGATGCGAAGTCTTCAGATTCTAGCGTAGGTGAAGAA
    ACTCTTCCAAGCCCATCCCTGAAACCAGAAAAAAAGGTTGCAGAAGCTGAGAAGAAGGTT
    GAAGAAGCTAAGAAAAAAGCCGAGGATCAAAAAGAAGAAGATCGTCGTAACTACCCAACC
    AATACTTACAAAACGCTTGAACTTGAAATTGCTGAGTCCGATGTGGAAGTTAAAAAAGCG
    GAGCTTGAACTAGTAAAAGAGGAAGCTAAGGAACCTCAAAACGAGGAAAAAGTTAAGCAA
    GCAAAAGCGGAAGTTGAGAGTAAACAAGCTGAGGCTACAAGGTTAGAAAAAATCAAGACA
    GATCGTAAAAAAGCAGAAGAAGAAGCTAAACGAAAAGCAGCAGAAGAAGATAAAGTTAAA
    GAAAAACCAGCTGAACAACCACAACCAGCGCCGGCTCCTCAACCAGAAAAACCAGCTCCA
    AAACCAGAAAAACCAGCTCCAGCTCCAAAACCAGAGAATCCAGCTGAACAACCAAAAGCA
    GAAAAACCAGCTGATCAACAAGCTGAAGAAGACTATGCTCGTAGATCAGAAGAAGAATAT
    AATCGCTTGACTCAACAGCAACCGCCAAAAACTGAAAAACCAGCACAACCATCTACTCCA
    AAAACAGGCTGGAAACAAGAAAATGGTATGTGGTACTTCTACAATACTGATGGTTCAATG
    GCGACAGGATGGCTCCAAAACAATGGCTCATGGTACTACCTCAACAGCAATGGCGCTATG
    GCGACAGGATGGCTCCAAAACAATGGTTCATGGTACTATCTAAACGCTAATGGTTCAATG
    GCAA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1624

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU15_RS10545 [old locus tag: SPNHU15_02229 ]
  • symbol: PspC
  • description: pneumococcal surface protein PspC, choline-binding form
  • length: 541
  • theoretical pI: 6.46885
  • theoretical MW: 61176
  • GRAVY: -1.23715

⊟Function[edit | edit source]

  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 52.7)
    and 2 more
    glucan-binding repeat (TIGR04035; HMM-score: 19.8)
    ectoine hydroxylase (TIGR02408; EC 1.-.-.-; HMM-score: 6)
  • TheSEED:
  • PFAM:
    no clan defined RICH; RICH domain (PF05062; HMM-score: 93.4)
    and 5 more
    Choline_binding (CL0694) Choline_bind_3; Choline-binding repeat (PF19127; HMM-score: 66)
    Choline_bind_1; Putative cell wall binding repeat (PF01473; HMM-score: 61)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 42.4)
    Choline_binding (CL0694) Choline_bind_2; Choline-binding repeat (PF19085; HMM-score: 9.9)
    WW (CL0680) WW; WW domain (PF00397; HMM-score: 6.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • SignalP: Signal peptide SP(Sec/SPI) length 37 aa
    • SP(Sec/SPI): 0.955481
    • TAT(Tat/SPI): 0.025951
    • LIPO(Sec/SPII): 0.004276
    • Cleavage Site: CS pos: 37-38. VHA-EG. Pr: 0.8850
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_208941171 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFASKSERKVHYSIRKFSIGVASVVVASLFLGGVVHAEGVRSGDTPKVTSSGDEVESHLKKILSEIQTQLDRKRHAKTVALINKLQDIKRTYSYKLNVLEEKPKAELTSKAKAELDAAFEQFKKEPELTKKVAEAQKKVEEAKKKAEDQKEEDFRNYPTNTYKTIELEIAESDVKVKEAELELLKEEAKEHRDEGTIKQVEEKVKSEKAEATRLEEIKTDREEAKRKADAKLKEAVEKNVATSEQDKLKGRRKRGVLGEPATPDKKENDAKSSDSSVGEETLPSPSLKPEKKVAEAEKKVEEAKKKAEDQKEEDRRNYPTNTYKTLELEIAESDVEVKKAELELVKEEAKEPQNEEKVKQAKAEVESKQAEATRLEKIKTDRKKAEEEAKRKAAEEDKVKEKPAEQPQPAPAPQPEKPAPKPEKPAPAPKPENPAEQPKAEKPADQQAEEDYARRSEEEYNRLTQQQPPKTEKPAQPSTPKTGWKQENGMWYFYNTDGSMATGWLQNNGSWYYLNSNGAMATGWLQNNGSWYYLNANGSMA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

  • PneumoExpress for strain D39V:

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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