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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 04-FEB-2016

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae INV200
  • locus tag: SPNINV200_10720 [new locus tag: SPNINV200_RS05740 ]
  • pan locus tag?: PNEUPAN002294000
  • symbol: zmpA
  • pan gene symbol?: zmpA
  • synonym: iga
  • product: IgA-protease

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNINV200_10720 [new locus tag: SPNINV200_RS05740 ]
  • symbol: zmpA
  • product: IgA-protease
  • replicon: chromosome
  • strand: -
  • coordinates: 1092356..1098082
  • length: 5727
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    3961
    4021
    4081
    4141
    4201
    4261
    4321
    4381
    4441
    4501
    4561
    4621
    4681
    4741
    4801
    4861
    4921
    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    5461
    5521
    5581
    5641
    5701
    ATGGAAAAGTATTTTGGTGAAAAACAAGAGCGTTTTTCATTTAGAAAATTATCAGTAGGA
    CTTGTATCTGCAACGATTTCAAGTTTATTTTTTATGTCTGTATTAGCTAGTTCATCTGTG
    GATGCTCAAGAAACTGCGGGAGTTCACTATAAATATGTGGCAGATTCAGAGCTATCATCA
    GAAGAAAAGAAGCAGCTTGTCTATGATATTCCGACATACGTGGAGAATGATGATGAAACT
    TATTATCTTGTTTATAAGTTAAATTCTCAAAATCAACTGGCGGAATTACCAAATACTGGA
    AGCAAGAATGAGAGGCAAGCCCTAGTTGCTGGTGCTAGCTTAGCTGCTCTGGGAATTTTA
    ATTTTTGCTGTTTCCAAGAAAAAGGTTAAGAATAAAACGGTATTACATTTAGTATTGGTT
    GCAGGAATAGGAAATGGTGTCTTAGTTTCAGTCCATGCTTTAGAAAATCATCTTTTGCTA
    AATTACAATACGGACTATGAATTGACCTCTGGAGAAAAATTACCTCTTCCTAAAGAGATT
    TCAGGTTACACTTATATTGGATATATCAAAGAGGGAAAAACGACTTCTGATTTTGAAGTA
    AGTAATCAAGAAAAATCAGCAGCCACTCCTACAAAACAACAAAAGGTGGATTATAATGTT
    ACACCAAATTTTGTAGACCATCCATCAACAGTACAAGCTATTCAGGAACAAACACCTGTT
    TCTTCAACTAAGCCGACAGAAGTTCAAGTAGTTGAAAAACCTTTCTCTACTAAATTAATC
    AATCCAAGAAAAGAAGAGAAACAATCTTCAGATTCTCAAGAACAATTAGCCGAACATAAG
    AATCTAGAAACGAAGAAAGAGGAGAAGATTTCTCCAAAAGAAAAGACTGGGGTAAATACA
    TTAAATCCACAGGATGAAGTTTTATCAGGTCAATTGAACAAACCTGAACTCTTATATCGT
    GAGGAAACTATAGAGACAAAAATAGATTTTCAAGAAGAAACTCAAGAAAATCCTGATTTA
    GCTGAAGGAACTGTAAGAGTAAAACAAGAAGGTAAATTAGGTAAGAAAGTTGAAATCGTC
    AGAATATTCTCTGTAAACAAGGAAGAAGTTTCGCGAGAAATTGTTTCAACTTCAACGACT
    GCGCCTAGTCCAAGAATAGTCGAAAAAGGTACTAAAAAAACTCAAGTTATAAAGGAACAA
    CCTGAGACTGGTGTAGAACATAAGGACGTACAGTCTGGAGCTATTGTTGAACCCGCAATT
    CAGCCTGAGTTGCCCGAAGCAGTAGTAAGTGATAAAGGCGTACCAGAAGTTCAACCAGCG
    TTATCGGAAGCAGTCGTAACCGACAAAGGTGAGCCCGCTGTCCAACCAGAGCTATCGGAA
    GCAGTCGTAACCGACAAAGGTGAGCCCGCTGTCCAACCAGAGCTATCGGAAGCAGTCGTA
    ACCGACAAAGGTGAGCCCGCTGTCCAACCAGAGCTACCGGAAGCAGTAGTAAGTGATAAA
    GGTGAACCAGCAGTCCAACCAGAGCTACCGGAAGCGGTTGTGACTGACAAAGGTGAGACT
    GAGGTTCAACCAGAGTCGCCAGATACTGTGGTAAGTGATAAAGGTGAACCTAAACAGGTA
    GCACCGCTTCCAGAATATACAGGACCACAAGCCAGCGCTATTGTTGAACCAGAGCAGGTA
    GCACCACTACCAGAATACACAGGGGTACAAGCCGGATCGATAGTCGAGCCAGAGAAAGTA
    GAAGCACCGAAAGAATATACTGGTAAAATCGAACAACCTAGTGCAGAAGATACTAAACCT
    GAAAATGAGGCAAGCTCTACAAATGGGGAATCGGAACGTCCTAAAGATAAAATTAAAGAA
    GAAAAACAAGTCGACAAGAAACTAGAACTTAGAAATGTTTCAAACGTGGAATTATATACG
    GTAGAAAATAATAAATATCGACATATTACGGCTGTAGATGGTGCTTTAGATAGTTCATTG
    AAGTATTTCATGAAGGTAAAATCAGAAAATTTTAAAGATATAATGTTGCCTGTTACTAAA
    ATTGAAAGTACAACAAAAAACAATAAAGAAGTATACAAAATTGTGGCTCATGCAGAAAAT
    CTAATTCAACACGAAAACAATGTTATTTCGAATGACTATACATATTATTTACCAAAAACT
    CAGCAAAGTGAAACTGGCGTCTATACATCATTTAAAAATTTAGTTGATGCAATGAATAGT
    GACCCTAATGGAACATTCCATTTAGGTGCAACTATGGATGCTCGTGAAGTTGAACTTCCG
    GATGATCAAGAAAGTTATGTAAAAAATGAATTTTACGGAAAATTAATAGGTGAAAATAAT
    GGTAAGTATTATGCTATTTATAACTTGAAAAAACCTTTATTTAAAACTCTAAACACCGCT
    ACTATTCAGAATCTTTCAATAAAAGAAGCGAATGTTTCTTCTAAAGAAGATGCTGCTACA
    ATATCGAAAGAAGCAAAATACAATACTCTTATAGATAATGTTCATTCTGATGGTATTATA
    GCTGGTGAACGTGGAATTGGTGGATTGGTTTCAAAAGTAGATAACTCGAGAATTTCTAAT
    AGTAGTTTTACAGGCAGAATAACTAACACATATGATACAACTGCAGGGTATGAAATTGGT
    GGTTTAGTAGGTAAACTTTCTGGTTCGCTTGCTTCTATAGAGAAATCAATAGCATCGATT
    GACATAGCCTCTAATGCAAAATCAGGAGATCAAATTGTTGGTGGTATAGCCGGAGTTGTT
    GAGAAAAGTGCGACAATTAAGTATAGCTATGTTGAAGGAAATGTTAACAATGTGCGACAC
    TTTGGTAAAGTTGGGGGAGTTGCAGGTAATCTTTGGGATAGAGATTCACAAGATGTAAGT
    AAATCAGGTAAACTATCATATGTTTTAAGTGATGTCAATGTTACGAATGGTAATGCTATA
    GCTGGCTATAATTTCAATGGAATAAAAACGATTGAAACATATAGCAATAAAAATAATAAG
    GTAGTAAACGTAGTACAAGAAGATGATGAGGTTGTGACTAAAGATTCAGATGTACAAAGA
    GGTACGGTATTAGATGCTGATAAAGTAAAAGAGAAAAAGGTAGAATTGGTTTCTAAACAC
    AGCACTAAAGTAGAAGATTTTGATTTTACTTCAAGATACAATACTAATTACAATGAAGTA
    ACAGGTTACCAACAGTCGAGAGAACAAGTATATAAAAATATTGAAAAATTACTTCCTTTC
    TATAACAGAGAAACAATAGTTAAGTATGGTAATTTAGTAGAGGATAACAGTGACTTATTT
    ACTAAAAAACTTCTATCAGTTGTTCCTATGAAGAACAATGAAGTAATAACTGATATTAAT
    AAAAATAAACAAGAAATAAACAAATTGTTATTACATTTTGAAGGTAACAAATCACGAGTA
    TTAAATATTGCATATAAGAATGATTTCTCTAAAGTTGCTGAGTATGATATAGCTAATACA
    AAATTAATGTATACACCTAATACAATGCTGCATGATTATAATAATATTGTAAAAACTATT
    TTAAATGATCTGAAATCTGTTCAATATAGTTCAGCTGACGTTAGAAAAGTATTAGATATT
    TCTGGTAATATAAAATTAACAGAGTTATATTTAGGTGAACAATTTGAAAAAACAAAAGCA
    AATATAGAAGACAGTTTATCAAAACTACTTACTGCAGATGCTGCAATAGTGGAAAATAAC
    AATAAGGTAATAGATAATTATGTAATTGAGAAAATAAAAAATAATAAGGAAGCCTTATTG
    TTAGGATTAACGTATTTAGAACGCTGGTATAATTTTAATTATGGAGAAACCAATGCTAAA
    GATTTAATAATGTACCACTTGGATTTCTTTGGTAAATCAAATAGTTCTGCATTAGATAAT
    GTTATTGAGTTAGGTAAATCTGGATTTAACAATTTATTAGCAAAAAATAATGTAATTACT
    TATAATGTATTATTAGCGAAAAATTATGGAACTGAAAGTTTATTTAAAGCATTAGAAGGA
    TATAGAAAAGTATTCTTACCAACAATTTCTAACAATGAGTGGTTTAAAAAACAAACAAAA
    GCATATATTGTAGAAGAAAAATCTACAATTGAAGAGGGAAGAGAAAAACAAGGAAAAGAG
    GGAACTAAATATTCTATTGGGGTATATGATAGATTAACTAATCCATCTTGGAAATATCAA
    AGTATGGTCTTACCACTATTAACTTTACCTGAAGAAAAAACAGTGTTTATGATAGCGAAT
    ATTTCCACTATTGGATTTGGAGCCTATGACAGATATAGAAGTTCAGAATATCCTAAGGGA
    GAAAAGTTAAACAAATTTGTAGAAGATAACGCCAAAGAAGCGGCTAAACGATTTAGAGAT
    CATTATGATTATTGGTATAAGATATTAGATAACGATAATAAAGAAAAATTATATAGAAGT
    ATTCTAGTATATGATGCTTTCAAATTTGGTACTGACAAAGATAAAGACAAAGTAACTCAT
    CAAGCTACTTTTGAAACTGATCATCCAGCTATAAAATACTTCTTTGGACCTGCGGGAAAT
    AATGTTGTTCATAATGGACACGGAGCATATGCTACCGGAGATGCATTCTATTATATGGCA
    TATCGTATGTTGGATAAAGATGGAGCTGTAACATATACTCATGAAATGACACATAACTCA
    GATAGAGAGATTTATCTTGGAGGATATGGAAGAAGAAGCGGATTAGGACCTGAGTTTTAT
    GCAAAAGGATTATTACAAGCTCCGGATCATCCATATGATCCAACAATAACAATTAACTCT
    GTCTTGAAATATGAGGATTCAGAAAATTCAACAAGACTTCAAGTAGCTGATCCAACTCAA
    CGATTTAATAGTGCAGAAGACCTACATAATTATATGCATAATATGTTTGATGTAATTTAT
    ATGTTAGAATATTTAGAAGGAAAAGCTGTAGCTAATTTAGAAACAAATCAAAAATATGAG
    TTACTAAGAAAAATTGAAAATAAATTTGATCTTGATCAAGACGGTAATAATGTATACGCG
    ACAAATGTTGTTCGCAGATTAACGATGGATGAAGTTAATAAATTAAATTCTTTTGATAGT
    TTAATTGAAAATGATATTATTACTAGCAGAGGGTACAAAGACCAAGAATATAAGAGAAAT
    GGTTATTATACAATTGATTTATTTTCACCGATTTATTCAGCTCTTAGTGGAGAGAAAGGG
    ACTCCTGGTGATTTAATGGGACGCCGTATAGCATTCGAATTATTAGCTGCAAAAGGATAT
    AAAGAGGGCATGGTACCTTATATCTCAAATCAATATGAAAAAGATGCAAAAGCGGCGGGA
    AGTAAGATTAATTCTTATGGTAAAGAAGTAGGTTTAGTTACAGATGAATTAGTACTTGAA
    AAAGTATTTAATGGTCAATATAAAACTTGGACACAATTCAAGAAGGATATGTATAAGGAA
    AGAGAAAAACAATTCAGTAAACTAAATAGAGTTAACTTTATTAATCCTAATAATCCATTG
    AGTCGTCAACGAAATGTATCGGTTACGGATATAGGTGTACTAGAGAGAATGATTGTCGAA
    GCAGTGAGAGATGATGCGCAAGATGACGTAGCAAAATTTTACCCAGAAACAAATAGTAGA
    GTTCTTAAACTGAAAAAAGCAATATATAAAGCTTATCTTGACCAAACAAATGATTTTAGA
    AGTTCAATTTTTGAGAATAAAAAATAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3660
    3720
    3780
    3840
    3900
    3960
    4020
    4080
    4140
    4200
    4260
    4320
    4380
    4440
    4500
    4560
    4620
    4680
    4740
    4800
    4860
    4920
    4980
    5040
    5100
    5160
    5220
    5280
    5340
    5400
    5460
    5520
    5580
    5640
    5700
    5727

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNINV200_10720 [new locus tag: SPNINV200_RS05740 ]
  • symbol: ZmpA
  • description: IgA-protease
  • length: 1908
  • theoretical pI: 5.17225
  • theoretical MW: 214227
  • GRAVY: -0.615671

⊟Function[edit | edit source]

  • reaction:
    EC 3.4.24.-?  ExPASy
  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 43.3)
    and 2 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 21.3)
    Genetic information processing DNA metabolism DNA replication, recombination, and repair DNA (cytosine-5-)-methyltransferase (TIGR00675; EC 2.1.1.37; HMM-score: 15.6)
  • TheSEED  :
    • IgA-specific metalloendopeptidase (EC 3.4.24.13)
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 884.7)
    and 5 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 242.3)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 55.8)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 36.1)
    Glug; The GLUG motif (PF07581; HMM-score: 31.8)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 29.6)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0002
    • Cytoplasmic Membrane Score: 0.0044
    • Cell wall & surface Score: 0.8005
    • Extracellular Score: 0.195
  • SignalP: Signal peptide SP(Sec/SPI) length 42 aa
    • SP(Sec/SPI): 0.91723
    • TAT(Tat/SPI): 0.067255
    • LIPO(Sec/SPII): 0.005174
    • Cleavage Site: CS pos: 42-43. VDA-QE. Pr: 0.9143
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CBW34705 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTKLINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIETKIDFQEETQENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPSPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAIQPELPEAVVSDKGVPEVQPALSEAVVTDKGEPAVQPELSEAVVTDKGEPAVQPELSEAVVTDKGEPAVQPELPEAVVSDKGEPAVQPELPEAVVTDKGETEVQPESPDTVVSDKGEPKQVAPLPEYTGPQASAIVEPEQVAPLPEYTGVQAGSIVEPEKVEAPKEYTGKIEQPSAEDTKPENEASSTNGESERPKDKIKEEKQVDKKLELRNVSNVELYTVENNKYRHITAVDGALDSSLKYFMKVKSENFKDIMLPVTKIESTTKNNKEVYKIVAHAENLIQHENNVISNDYTYYLPKTQQSETGVYTSFKNLVDAMNSDPNGTFHLGATMDAREVELPDDQESYVKNEFYGKLIGENNGKYYAIYNLKKPLFKTLNTATIQNLSIKEANVSSKEDAATISKEAKYNTLIDNVHSDGIIAGERGIGGLVSKVDNSRISNSSFTGRITNTYDTTAGYEIGGLVGKLSGSLASIEKSIASIDIASNAKSGDQIVGGIAGVVEKSATIKYSYVEGNVNNVRHFGKVGGVAGNLWDRDSQDVSKSGKLSYVLSDVNVTNGNAIAGYNFNGIKTIETYSNKNNKVVNVVQEDDEVVTKDSDVQRGTVLDADKVKEKKVELVSKHSTKVEDFDFTSRYNTNYNEVTGYQQSREQVYKNIEKLLPFYNRETIVKYGNLVEDNSDLFTKKLLSVVPMKNNEVITDINKNKQEINKLLLHFEGNKSRVLNIAYKNDFSKVAEYDIANTKLMYTPNTMLHDYNNIVKTILNDLKSVQYSSADVRKVLDISGNIKLTELYLGEQFEKTKANIEDSLSKLLTADAAIVENNNKVIDNYVIEKIKNNKEALLLGLTYLERWYNFNYGETNAKDLIMYHLDFFGKSNSSALDNVIELGKSGFNNLLAKNNVITYNVLLAKNYGTESLFKALEGYRKVFLPTISNNEWFKKQTKAYIVEEKSTIEEGREKQGKEGTKYSIGVYDRLTNPSWKYQSMVLPLLTLPEEKTVFMIANISTIGFGAYDRYRSSEYPKGEKLNKFVEDNAKEAAKRFRDHYDYWYKILDNDNKEKLYRSILVYDAFKFGTDKDKDKVTHQATFETDHPAIKYFFGPAGNNVVHNGHGAYATGDAFYYMAYRMLDKDGAVTYTHEMTHNSDREIYLGGYGRRSGLGPEFYAKGLLQAPDHPYDPTITINSVLKYEDSENSTRLQVADPTQRFNSAEDLHNYMHNMFDVIYMLEYLEGKAVANLETNQKYELLRKIENKFDLDQDGNNVYATNVVRRLTMDEVNKLNSFDSLIENDIITSRGYKDQEYKRNGYYTIDLFSPIYSALSGEKGTPGDLMGRRIAFELLAAKGYKEGMVPYISNQYEKDAKAAGSKINSYGKEVGLVTDELVLEKVFNGQYKTWTQFKKDMYKEREKQFSKLNRVNFINPNNPLSRQRNVSVTDIGVLERMIVEAVRDDAQDDVAKFYPETNSRVLKLKKAIYKAYLDQTNDFRSSIFENKK

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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