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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_0306 [new locus tag: SP_RS01495 ]
  • pan locus tag?: PNEUPAN001093000
  • symbol: SP_0306
  • pan gene symbol?: celR
  • synonym:
  • product: putative transcriptional regulator

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_0306 [new locus tag: SP_RS01495 ]
  • symbol: SP_0306
  • product: putative transcriptional regulator
  • replicon: chromosome
  • strand: +
  • coordinates: 279127..280608
  • length: 1482
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    ATGAATGTGTTAAACATTAAAGAGAAAGATATCCTTCAATTTTTAATAAAAAATAAGGAA
    CGTTTTGTTACAAGCAAAGAACTGGCAGAATATTTATCCTGTTCAGATAGAACTGTCCGT
    AATGTACTGAAATTAATTGAGAAGACAATGATTATTCAAGGAGTCCGGTTGATTTCAAAA
    CAAGGTCAAGGGTATCAAATATTTTTTGAGAATCAAGGCGCTTACCAGGAGTTTAGACAA
    ACTTATGAACTGGAAGAAGACTATACGAAAACTGCGGTTTCAAAAGGTGATGATCGTTTA
    GTATTTATCTTAAATAAATTATTATTTGAGCAAGTTCCAGTTCTTTTTGATGATTTAGCT
    GATGAACTTTACGTTAGTCGTTCAACATTATCTCATGATTTCAGAAAGATACGAGTGATG
    TTATCAGAGTATAATTTGTCCATTGAGAGTAGGGCGAATAAAGGAGTTTATGTCTCAGGC
    GAGGAACGTGATAAACGACGTTTTATCATAAATTATTTCCTAGAGAATCAATTTTTTAAA
    ACAATACATTGCTATGTAAAATTTAACTTTTTTGATCAAACTGTTCCATTAGAAGAATTT
    GCTAGAATTGTTTTGGATGAATGCCAAGAGGCCAACCTAAAACTATCTGATTTTGTACTA
    CAGAATTTAGTAGTTCACATAGCATTGTCTGTGATTCGTTTAAAATCCGGATTTGAAATA
    AAAAATATAGACTGTCAGATGACTGATGATGCAATAGAGAGAAAGGTTGCCCAAAGAATT
    CTTTCTAAAGTAAGAGAAGTAACAAATCAGGAATTTCCAGTTCAGGAAATAGACTACATT
    ACTTTGCATTTGTTAGCTAAGAGTCAACAATGTCAAAAAAATCAGAAGAATATTTCTGAA
    GAAGTTTTAAAAAAATCTTTATTTAAAACATTTCAGAATTTAGGATTAGATGATATGTAT
    AACTTTTCTTCAGATTTCCAACTAATTGAAGGATTGATAACTCATCTAATGACACTACAA
    GTACGTTTAGAAAGCCGGATTACCTTAAATAACCCTTTGGTAGATGAAATTAAACAGAAT
    TATAGTGATATATTCTTTATGACTAGAGAAATTCTTGCAAATATGGACAAGTTCTTGGAG
    TGGACAATATCAGATGATGAAGTAGCATATGTAAGTCTTCACTTTTTAGCTGCTATGGAA
    CGTAGCAAAGAGAGTACTAAGTTTAATATTCTTGCTATTTGTGCAACAGGATTTGGTGCA
    GCCCAAATGTTAAGAAATCGTTTGGAAACGGAGTTTGGGAAGCGAGTAGAAGTTGTTGAT
    GTAATAGGCTACTATGAATTGAATCAAGAAAAACTTAAAGGAATAGATTTTATAGTGTCA
    GCTATTGATTTATCAAATCTATATTTTCAAATCCCAGTTTTTAAAGTTAGTGTGTTTCTT
    AAGAGTGATGAGATGGAAATGATTAGAAAAGCTATGGATTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1482

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_0306 [new locus tag: SP_RS01495 ]
  • symbol: SP_0306
  • description: putative transcriptional regulator
  • length: 493
  • theoretical pI: 5.2321
  • theoretical MW: 57714.1
  • GRAVY: -0.181744

⊟Function[edit | edit source]

  • TIGRFAM:
    Unknown function General DNA binding domain, excisionase family (TIGR01764; HMM-score: 14.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 14.6)
    Signal transduction Regulatory functions DNA interactions iron-sulfur cluster biosynthesis transcriptional regulator SufR (TIGR02702; HMM-score: 14.6)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Other FeS assembly SUF system regulator (TIGR02944; HMM-score: 13.2)
    Signal transduction Regulatory functions DNA interactions FeS assembly SUF system regulator (TIGR02944; HMM-score: 13.2)
    and 1 more
    RNA polymerase sigma factor, sigma-70 family (TIGR02937; HMM-score: 11)
  • TheSEED  :
    • Transcriptional antiterminator of lichenan operon, BglG family
    Carbohydrates Di- and oligosaccharides Beta-Glucoside Metabolism  Transcriptional antiterminator of lichenan operon, BglG family
  • PFAM:
    PRD (CL0166) PRD; PRD domain (PF00874; HMM-score: 129.1)
    and 24 more
    HTH (CL0123) HTH_11; HTH domain (PF08279; HMM-score: 76.2)
    Mga; Mga helix-turn-helix domain (PF05043; HMM-score: 50.3)
    Phosphatase (CL0031) PTS_IIB; PTS system, Lactose/Cellobiose specific IIB subunit (PF02302; HMM-score: 25.5)
    HTH (CL0123) HTH_Mga; M protein trans-acting positive regulator (MGA) HTH domain (PF08280; HMM-score: 23.8)
    HTH_DeoR; DeoR-like helix-turn-helix domain (PF08220; HMM-score: 19.4)
    HrcA_DNA-bdg; Winged helix-turn-helix transcription repressor, HrcA DNA-binding (PF03444; HMM-score: 17.8)
    HTH_5; Bacterial regulatory protein, arsR family (PF01022; HMM-score: 17.6)
    HTH_10; HTH DNA binding domain (PF04967; HMM-score: 17.6)
    PuR_N; Bacterial purine repressor, N-terminal (PF09182; HMM-score: 17.5)
    MBB (CL0193) Omp85_2; OMP85 superfamily (PF19143; HMM-score: 17)
    HTH (CL0123) SgrR_N; Sugar transport-related sRNA regulator N-term (PF12793; HMM-score: 16.9)
    MarR_2; MarR family (PF12802; HMM-score: 16.6)
    HTH_17; Helix-turn-helix domain (PF12728; HMM-score: 16.3)
    HTH_20; Helix-turn-helix domain (PF12840; HMM-score: 15.9)
    Trans_reg_C; Transcriptional regulatory protein, C terminal (PF00486; HMM-score: 15.8)
    HTH_AraC; Bacterial regulatory helix-turn-helix proteins, AraC family (PF00165; HMM-score: 15.3)
    HTH_Crp_2; Crp-like helix-turn-helix domain (PF13545; HMM-score: 15)
    Phage_CI_repr; Bacteriophage CI repressor helix-turn-helix domain (PF07022; HMM-score: 14.8)
    TFIIE_beta; TFIIE beta subunit core domain (PF02186; HMM-score: 13.3)
    Sigma70_r4_2; Sigma-70, region 4 (PF08281; HMM-score: 12.5)
    no clan defined Nas2_N; Nas2 N_terminal domain (PF18265; HMM-score: 12.5)
    HTH (CL0123) HTH_36; Helix-turn-helix domain (PF13730; HMM-score: 12.3)
    GerE; Bacterial regulatory proteins, luxR family (PF00196; HMM-score: 12.2)
    HTH_24; Winged helix-turn-helix DNA-binding (PF13412; HMM-score: 12)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors: CelB, cellobiose-specific PTS component EIIB; HPr, phosphocarrier protein
  • genes regulated by CelR*, TF important in Cellobiose utilizationRegPrecise
    repression
    bglA-1
    celB* > celR* > SP_0307 > celC* > SP_0309 > celD*

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.004825
    • TAT(Tat/SPI): 0.000206
    • LIPO(Sec/SPII): 0.001868
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MNVLNIKEKDILQFLIKNKERFVTSKELAEYLSCSDRTVRNVLKLIEKTMIIQGVRLISKQGQGYQIFFENQGAYQEFRQTYELEEDYTKTAVSKGDDRLVFILNKLLFEQVPVLFDDLADELYVSRSTLSHDFRKIRVMLSEYNLSIESRANKGVYVSGEERDKRRFIINYFLENQFFKTIHCYVKFNFFDQTVPLEEFARIVLDECQEANLKLSDFVLQNLVVHIALSVIRLKSGFEIKNIDCQMTDDAIERKVAQRILSKVREVTNQEFPVQEIDYITLHLLAKSQQCQKNQKNISEEVLKKSLFKTFQNLGLDDMYNFSSDFQLIEGLITHLMTLQVRLESRITLNNPLVDEIKQNYSDIFFMTREILANMDKFLEWTISDDEVAYVSLHFLAAMERSKESTKFNILAICATGFGAAQMLRNRLETEFGKRVEVVDVIGYYELNQEKLKGIDFIVSAIDLSNLYFQIPVFKVSVFLKSDEMEMIRKAMD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulators: CelR* (repression) regulon, CelR (repression) regulon, CcpA regulon
    CelR*(TF)important in Cellobiose utilization; RegPrecise 
    CelR(TF)important in Cellobiose utilization; RegPrecise 
    CcpA(TF)important in Global catabolite repression; RegPrecise 

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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