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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1079 [new locus tag: SP_RS05335 ]
  • pan locus tag?: PNEUPAN002217000
  • symbol: SP_1079
  • pan gene symbol?: obgE
  • synonym:
  • product: GTP-binding protein, GTP1/Obg family

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1079 [new locus tag: SP_RS05335 ]
  • symbol: SP_1079
  • product: GTP-binding protein, GTP1/Obg family
  • replicon: chromosome
  • strand: +
  • coordinates: 1014604..1015908
  • length: 1305
  • essential: yes [1] DEG

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    ATGTTTTTAGATACAGCTAAGATTAAGGTCAAGGCTGGTAATGGTGGCGATGGTATGGTT
    GCCTTTCGTCGTGAAAAATATGTCCCTAATGGAGGCCCTTGGGGTGGTGATGGTGGTCGT
    GGAGGCAATGTGGTCTTCGTTGTAGACGAAGGACTACGTACCTTGATGGATTTCCGCTAC
    AATCGTCATTTCAAGGCTGATTCTGGTGAAAAAGGGATGACCAAAGGGATGCATGGTCGT
    GGTGCTGAGGACCTTAGAGTTCGAGTACCACAAGGTACGACTGTTCGTGATGCGGAGACT
    GGCAAGGTTTTAACAGATTTGATTGAACATGGGCAAGAATTTATCGTTGCCCACGGTGGT
    CGTGGTGGACGTGGAAATATTCGTTTCGCGACACCAAAAAATCCTGCACCGGAAATCTCT
    GAAAATGGAGAACCAGGTCAGGAACGTGAGTTACAATTGGAACTAAAAATCTTGGCAGAT
    GTCGGTTTAGTAGGATTCCCATCTGTAGGGAAGTCAACACTTTTAAGTGTTATTACCTCA
    GCTAAGCCTAAAATTGGTGCCTACCACTTTACCACTATTGTACCAAATTTAGGTATGGTT
    CGCACCCAATCAGGTGAATCCTTTGCAGTAGCCGACTTGCCAGGTTTGATTGAAGGGGCT
    AGTCAAGGTGTTGGTTTGGGAACTCAGTTCCTCCGTCACATCGAGCGTACACGTGTTATC
    CTTCACATCATTGATATGTCAGCTAGCGAGGGCCGTGATCCATATGAGGACTACCTAGCT
    ATCAATAAAGAGCTGGAGTCTTACAATCTTCGCCTCATGGAGCGTCCACAGATTATTGTA
    GCTAATAAGATGGACATGCCTGAGAGTCAGGAAAATCTTGAAGACTTTAAGAAAAAATTG
    GCTGAAAATTATGATGAATTTGAAGAGTTACCAGCTATCTTCCCAATTTCTGGATTGACC
    AAGCAAGGTCTGGCAACACTTTTAGATGCTACAGCTGAATTGTTAGACAAGACACCAGAA
    TTTTTGCTCTACGACGAGTCCGATATGGAAGAAGAAGCTTACTATGGATTTGACGAAGAA
    GAAAAAGCCTTTGAAATTAGTCGTGATGACGATGCGACATGGGTACTTTCTGGTGAAAAA
    CTCATGAAACTCTTTAATATGACCAACTTTGATCGTGATGAATCTGTCATGAAATTTGCC
    CGTCAGCTTCGTGGTATGGGGGTTGATGAAGCCCTTCGTGCGCGTGGAGCTAAAGATGGG
    GATTTGGTCCGCATTGGTAAATTTGAGTTTGAATTTGTAGACTAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1305

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1079 [new locus tag: SP_RS05335 ]
  • symbol: SP_1079
  • description: GTP-binding protein, GTP1/Obg family
  • length: 434
  • theoretical pI: 4.69344
  • theoretical MW: 48130.1
  • GRAVY: -0.423272

⊟Function[edit | edit source]

  • TIGRFAM:
    Genetic information processing Protein synthesis Other Obg family GTPase CgtA (TIGR02729; HMM-score: 461.2)
    and 13 more
    Obg family GTPase CgtA, C-terminal extension (TIGR03595; HMM-score: 92.6)
    Unknown function General GTP-binding protein YchF (TIGR00092; HMM-score: 60.8)
    Unknown function General small GTP-binding protein domain (TIGR00231; HMM-score: 49.1)
    Unknown function General GTP-binding protein HflX (TIGR03156; HMM-score: 43)
    Genetic information processing Protein synthesis Other ribosome-associated GTPase EngA (TIGR03594; HMM-score: 39.7)
    Genetic information processing Protein synthesis Other GTP-binding protein Era (TIGR00436; HMM-score: 36.9)
    Metabolism Transport and binding proteins Amino acids, peptides and amines LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 23.3)
    Signal transduction Regulatory functions Protein interactions LAO/AO transport system ATPase (TIGR00750; EC 2.7.-.-; HMM-score: 23.3)
    Metabolism Transport and binding proteins Cations and iron carrying compounds ferrous iron transport protein B (TIGR00437; HMM-score: 19.8)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YlqF (TIGR03596; HMM-score: 16.7)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTP-binding protein YsxC (TIGR03598; HMM-score: 15.5)
    Genetic information processing Protein synthesis Other ribosome biogenesis GTPase YqeH (TIGR03597; HMM-score: 12.8)
    Metabolism Transport and binding proteins Nucleosides, purines and pyrimidines GTP-binding protein (TIGR00991; HMM-score: 11.8)
  • TheSEED  :
    • GTP-binding protein Obg
    Protein Metabolism Protein biosynthesis Universal GTPases  GTP-binding protein Obg
  • PFAM:
    no clan defined GTP1_OBG; GTP1/OBG (PF01018; HMM-score: 198.9)
    and 9 more
    DUF1967; Domain of unknown function (DUF1967) (PF09269; HMM-score: 87.9)
    P-loop_NTPase (CL0023) MMR_HSR1; 50S ribosome-binding GTPase (PF01926; HMM-score: 80.6)
    FeoB_N; Ferrous iron transport protein B (PF02421; HMM-score: 39.7)
    MeaB; Methylmalonyl Co-A mutase-associated GTPase MeaB (PF03308; HMM-score: 23.7)
    GTP_EFTU; Elongation factor Tu GTP binding domain (PF00009; HMM-score: 20.8)
    ATP_bind_1; Conserved hypothetical ATP binding protein (PF03029; HMM-score: 16)
    Arf; ADP-ribosylation factor family (PF00025; HMM-score: 15.1)
    ABC_tran; ABC transporter (PF00005; HMM-score: 12.7)
    RsgA_GTPase; RsgA GTPase (PF03193; HMM-score: 12.3)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cytoplasmic
    • Cytoplasmic Score: 7.5
    • Cytoplasmic Membrane Score: 1.15
    • Cellwall Score: 0.62
    • Extracellular Score: 0.73
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.9906
    • Cytoplasmic Membrane Score: 0.0016
    • Cell wall & surface Score: 0
    • Extracellular Score: 0.0078
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.024799
    • TAT(Tat/SPI): 0.000807
    • LIPO(Sec/SPII): 0.002634
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFLDTAKIKVKAGNGGDGMVAFRREKYVPNGGPWGGDGGRGGNVVFVVDEGLRTLMDFRYNRHFKADSGEKGMTKGMHGRGAEDLRVRVPQGTTVRDAETGKVLTDLIEHGQEFIVAHGGRGGRGNIRFATPKNPAPEISENGEPGQERELQLELKILADVGLVGFPSVGKSTLLSVITSAKPKIGAYHFTTIVPNLGMVRTQSGESFAVADLPGLIEGASQGVGLGTQFLRHIERTRVILHIIDMSASEGRDPYEDYLAINKELESYNLRLMERPQIIVANKMDMPESQENLEDFKKKLAENYDEFEELPAIFPISGLTKQGLATLLDATAELLDKTPEFLLYDESDMEEEAYYGFDEEEKAFEISRDDDATWVLSGEKLMKLFNMTNFDRDESVMKFARQLRGMGVDEALRARGAKDGDLVRIGKFEFEFVD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ Jane A Thanassi, Sandra L Hartman-Neumann, Thomas J Dougherty, Brian A Dougherty, Michael J Pucci
    Identification of 113 conserved essential genes using a high-throughput gene disruption system in Streptococcus pneumoniae.
    Nucleic Acids Res: 2002, 30(14);3152-62
    [PubMed:12136097] [WorldCat.org] [DOI] (I p)    Tim van Opijnen, Andrew Camilli
    A fine scale phenotype-genotype virulence map of a bacterial pathogen.
    Genome Res: 2012, 22(12);2541-51
    [PubMed:22826510] [WorldCat.org] [DOI] (I p)
  2. ↑ 2.0 2.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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