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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae TIGR4
  • locus tag: SP_1544 [new locus tag: SP_RS07605 ]
  • pan locus tag?: PNEUPAN002828000
  • symbol: aspC
  • pan gene symbol?: aspC
  • synonym:
  • product: aspartate aminotransferase

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SP_1544 [new locus tag: SP_RS07605 ]
  • symbol: aspC
  • product: aspartate aminotransferase
  • replicon: chromosome
  • strand: -
  • coordinates: 1451512..1452699
  • length: 1188
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    ATGAAACTATCCAACCGTGTTTTAGAAATGGAAGAAAGTGTGACTTTGGCTGCTGGAGCC
    CGTGCCAAAGCACTGAAGGCTGAGGGTAGAGATATTTTGTCTCTAACCTTGGGTGAGCCA
    GATTTCACTACTCCCAAAAATATCCAAGATGCCGCCATTGCATCGATTCGAGATGGGCGT
    GCTTCTTTTTATACAGTAACCTCAGGTCTGCCAGAGCTTAAGGCGGCGGTCAATAGCTAC
    TTTGAGCGCTTTTACGGCTATTCTGTAGCGTCAAATCAAGTGACAGTCGCTGCGGGAGCC
    AAATATTCTCTCTATACCTTCTTTATGGCTGTGGTCAATCCAGGTGATGAAGTCATCATC
    CCAACCCCATACTGGGTTAGCTATGGAGATCAGGTCAAGATGGCAGAAGGCGTTCCCGTC
    TTTGTTTCTGCTAAGGAAGACAATCACTTTAAGGTGACCGTAGAGCAGTTAGAAGCAGCT
    CGCACTGACAAGACCAAGGTTTTGGTGCTGAATTCGCCATCTAATCCCACAGGTATGATT
    TACACCCGTGAGGAACTCTTGGCAATTGGAAACTGGGCTGTAGAAAATGATATTCTCATC
    CTAGCAGACGATATCTATGGCCGCTTGGTTTATAATGGTCATGAGTTCACACCGATTTCT
    AGCCTATCGGAAGCGATTCGCAAGCAAACAGTGGTCATCAATGGTGTGTCTAAAACTTAT
    GCCATGACTGGTTGGCGGATTGGTTATGCCGTTGGAGAAGCAGACATTATCGCTGCCATG
    TCCAAGATTGCAGGTCAAACAACTTCGAATCCGTCAGCAGTAGCCCAATATGCAGCAGTT
    GAGGCTCTATCAGGTGAGCAAGATACTGTAGAAAGCATGCGTCAGGCCTTTGAGGAACGT
    CTTAATACCATCTATCCCCTCCTTGCAGAGGTACCAGGATTTGAAGTGGTCAAACCGCAA
    GGGGCCTTCTATCTCTTCCCAAATGTCAAAAAGGCCATGGAGATGAAAGGCTACACGGAT
    GTGACAGACTTTACAACTGTTATCTTAGAAGAAGCCGAAGTGGCCTTGGTAACAGGAGCT
    GGATTTGGAGCACCAGAAAATGTCCGCCTCAGCTATGCGACAGACCTAGACACGCTTAAA
    GAAGCAGTCGAACGCTTGAAAGCATTTATGGGTAGTGAGAATGATTGA
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1188

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SP_1544 [new locus tag: SP_RS07605 ]
  • symbol: AspC
  • description: aspartate aminotransferase
  • length: 395
  • theoretical pI: 4.46076
  • theoretical MW: 43014.5
  • GRAVY: -0.0349367

⊟Function[edit | edit source]

  • reaction:
    EC 2.6.1.1?  ExPASy
    Aspartate transaminase L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate
  • TIGRFAM:
    LL-diaminopimelate aminotransferase (TIGR03540; EC 2.6.1.83; HMM-score: 231.5)
    tyrosine/nicotianamine family aminotransferase (TIGR01265; HMM-score: 204.9)
    and 18 more
    Metabolism Energy metabolism Amino acids and amines tyrosine aminotransferase (TIGR01264; EC 2.6.1.5; HMM-score: 177.3)
    putative C-S lyase (TIGR04350; EC 4.4.-.-; HMM-score: 154.1)
    succinyldiaminopimelate transaminase (TIGR03537; EC 2.6.1.17; HMM-score: 138.8)
    succinyldiaminopimelate transaminase (TIGR03538; EC 2.6.1.17; HMM-score: 134.9)
    Cellular processes Cellular processes Biosynthesis of natural products capreomycidine synthase (TIGR03947; HMM-score: 129.7)
    Metabolism Amino acid biosynthesis Histidine family histidinol-phosphate transaminase (TIGR01141; EC 2.6.1.9; HMM-score: 119.2)
    succinyldiaminopimelate transaminase (TIGR03539; EC 2.6.1.17; HMM-score: 101.4)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin threonine-phosphate decarboxylase (TIGR01140; EC 4.1.1.81; HMM-score: 97)
    beta-methylarginine biosynthesis bifunctional aminotransferase (TIGR04544; EC 2.6.-.-; HMM-score: 88.2)
    LL-diaminopimelate aminotransferase (TIGR03542; EC 2.6.1.83; HMM-score: 75.3)
    enduracididine biosynthesis enzyme MppQ (TIGR04461; EC 2.-.-.-; HMM-score: 52.9)
    Metabolism Energy metabolism Amino acids and amines aspartate 4-decarboxylase (TIGR03801; EC 4.1.1.12; HMM-score: 48.1)
    Unknown function Enzymes of unknown specificity cysteine desulfurase family protein (TIGR01977; HMM-score: 23.9)
    Cell structure Cell envelope Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides TDP-4-keto-6-deoxy-D-glucose transaminase (TIGR02379; HMM-score: 21.2)
    aminotransferase, LLPSF_NHT_00031 family (TIGR04181; HMM-score: 17.3)
    Metabolism Amino acid biosynthesis Aspartate family O-succinylhomoserine sulfhydrylase (TIGR01325; EC 4.2.99.-; HMM-score: 15)
    enduracididine biosynthesis enzyme MppP (TIGR04462; EC 2.-.-.-; HMM-score: 13.8)
    cysteine desulfurase, NifS family (TIGR03403; EC 2.8.1.7; HMM-score: 11.3)
  • TheSEED  :
    • Aspartate aminotransferase (EC 2.6.1.1)
    Amino Acids and Derivatives Glutamine, glutamate, aspartate, asparagine; ammonia assimilation Glutamine, Glutamate, Aspartate and Asparagine Biosynthesis  Aspartate aminotransferase (EC 2.6.1.1)
    and 1 more
    Amino Acids and Derivatives Lysine, threonine, methionine, and cysteine Threonine and Homoserine Biosynthesis  Aspartate aminotransferase (EC 2.6.1.1)
  • PFAM:
    PLP_aminotran (CL0061) Aminotran_1_2; Aminotransferase class I and II (PF00155; HMM-score: 240.9)
    and 5 more
    DegT_DnrJ_EryC1; DegT/DnrJ/EryC1/StrS aminotransferase family (PF01041; HMM-score: 25.3)
    Aminotran_5; Aminotransferase class-V (PF00266; HMM-score: 16.2)
    Cys_Met_Meta_PP; Cys/Met metabolism PLP-dependent enzyme (PF01053; HMM-score: 15.1)
    OKR_DC_1; Orn/Lys/Arg decarboxylase, major domain (PF01276; HMM-score: 14.8)
    no clan defined Trypco1; Trypsin-co-occurring domain 1 (PF19493; HMM-score: 14.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helices: 0
  • DeepLocPro: Cytoplasmic
    • Cytoplasmic Score: 0.998
    • Cytoplasmic Membrane Score: 0.0002
    • Cell wall & surface Score: 0.0001
    • Extracellular Score: 0.0017
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.029116
    • TAT(Tat/SPI): 0.005369
    • LIPO(Sec/SPII): 0.003678
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MKLSNRVLEMEESVTLAAGARAKALKAEGRDILSLTLGEPDFTTPKNIQDAAIASIRDGRASFYTVTSGLPELKAAVNSYFERFYGYSVASNQVTVAAGAKYSLYTFFMAVVNPGDEVIIPTPYWVSYGDQVKMAEGVPVFVSAKEDNHFKVTVEQLEAARTDKTKVLVLNSPSNPTGMIYTREELLAIGNWAVENDILILADDIYGRLVYNGHEFTPISSLSEAIRKQTVVINGVSKTYAMTGWRIGYAVGEADIIAAMSKIAGQTTSNPSAVAQYAAVEALSGEQDTVESMRQAFEERLNTIYPLLAEVPGFEVVKPQGAFYLFPNVKKAMEMKGYTDVTDFTTVILEEAEVALVTGAGFGAPENVRLSYATDLDTLKEAVERLKAFMGSEND

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

  1. ↑ 1.0 1.1 Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, Ariana Hazery, Haley Echlin, Jason Rosch, Michelle M Meyer, Tim van Opijnen
    The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence.
    PLoS Pathog: 2018, 14(12);e1007461
    [PubMed:30517198] [WorldCat.org] [DOI] (I e)

⊟Relevant publications[edit | edit source]

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