PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 12-FEB-2025

⊟Summary

• organism: Streptococcus pneumoniae HU-OH
• locus tag: EL271_RS04070 [old locus tag: SPOH_0752 ]
• pan locus tag^?: PNEUPAN001836000
• symbol: EL271_RS04070
• pan gene symbol^?: —
• synonym:
• product: DUF6556 family protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: EL271_RS04070 [old locus tag: SPOH_0752 ]
• symbol: EL271_RS04070
• product: DUF6556 family protein
• replicon: chromosome
• strand: -
• coordinates: 758278..758706
• length: 429
• essential: unknown

⊟Accession numbers

• Location: NZ_AP018937 (758278..758706) NCBI
• BioCyc: EL271_RS04070 BioCyc
• MicrobesOnline:
• PneumoBrowse for strain D39V: SPV_0775 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  
  ATGTCTAACTATCGTAGAACTTCAAAACCGAAAACAGAACATATCAAAAAAGGCTTTACT
  GTTTTTCAAAAAACCATTACTACTATCGGTAGTATCCTTGGTTTGATTACAGCGGGTATC
  ACGATCATGAACGCCTTGGATAATAATAATAAAAATACTAAAAAAGAACCTACGACAAGC
  CAGACGACAACCTTTGTCAAAGAAATTCAAAAAGAATCCCCTCAGGAAAATACTACTCCA
  AATAAGGAAAATAACACTTCTCAAGAAAAAACACAACAAGAAGAAACGCCAAAATCTAGC
  GTCAAGGAAGAGAAAAAAAAAGATCAGAAAACAGCAACTCAGGACTCTACTACACCTGCT
  ACAAGTAAACCTGCCACTGAAAATGAAAAACAGCCCAATACTCCAACTTCAGAAAATAAT
  ACTCAATGA
  60
  120
  180
  240
  300
  360
  420
  429
  

⊟Protein

⊟General

• locus tag: EL271_RS04070 [old locus tag: SPOH_0752 ]
• symbol: EL271_RS04070
• description: DUF6556 family protein
• length: 142
• theoretical pI: 10.1273
• theoretical MW: 15846.4
• GRAVY: -1.42042

⊟Function

• TIGRFAM:
  integral membrane protein (TIGR04561; HMM-score: 11.9)
  Genetic information processing Transcription Degradation of RNA ribonuclease Y (TIGR03319; EC 3.1.-.-; HMM-score: 10.1)
  and 4 more
  Cellular processes Cellular processes Pathogenesis putative immunoglobulin-blocking virulence protein (TIGR04526; HMM-score: 7.5)
  Metabolism Energy metabolism TCA cycle dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex (TIGR01347; EC 2.3.1.61; HMM-score: 7.2)
  cobaltochelatase subunit (TIGR02442; EC 6.6.1.2; HMM-score: 6.3)
  pullulanase, extracellular (TIGR02102; HMM-score: 6)
• TheSEED: data available for D39, Hungary19A-6, TIGR4
• PFAM:
  no clan defined DUF6556; Family of unknown function (DUF6556) (PF20193; HMM-score: 97.1)
  and 19 more
  TrbC_VirB2 (CL0690) DUF4134; Domain of unknown function (DUF4134) (PF13572; HMM-score: 16.8)
  DMT (CL0184) Zip; ZIP Zinc transporter (PF02535; HMM-score: 13.1)
  no clan defined DUF3807; Protein of unknown function (DUF3807) (PF12720; HMM-score: 12.7)
  Multiheme_cytos (CL0317) C_GCAxxG_C_C; Putative redox-active protein (C_GCAxxG_C_C) (PF09719; HMM-score: 12.4)
  no clan defined DUF5427; Family of unknown function (DUF5427) (PF10310; HMM-score: 11.4)
  GPCR_A (CL0192) SID-1_RNA_chan; dsRNA-gated channel SID-1 (PF13965; HMM-score: 8.8)
  AhpD-like (CL0423) PA26; PA26 p53-induced protein (sestrin) (PF04636; HMM-score: 8.2)
  no clan defined RR_TM4-6; Ryanodine Receptor TM 4-6 (PF06459; HMM-score: 8.2)
  Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region (PF02932; HMM-score: 8)
  CIS_TMP; Contractile injection system tape measure protein (PF19268; HMM-score: 7.6)
  vMSA; Major surface antigen from hepadnavirus (PF00695; HMM-score: 7.5)
  Serinc; Serine incorporator (Serinc) (PF03348; HMM-score: 7.1)
  SLC12; Solute carrier family 12 (PF03522; HMM-score: 7.1)
  DDHD; DDHD domain (PF02862; HMM-score: 6.9)
  APC (CL0062) HCO3_cotransp; HCO3- transporter family (PF00955; HMM-score: 6.7)
  TPR (CL0020) Suf; Suppressor of forked protein (Suf) (PF05843; HMM-score: 6.6)
  no clan defined Snu56_snRNP; Snu56-like U1 small nuclear ribonucleoprotein component (PF19097; HMM-score: 6.2)
  Nucleocapsid (CL0156) Paramyxo_ncap; Paramyxovirus nucleocapsid protein (PF00973; HMM-score: 5.5)
  Peptidase_AD (CL0130) Presenilin; Presenilin (PF01080; HMM-score: 5.1)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helix: 1
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.0067
  • Cytoplasmic Membrane Score: 0.5376
  • Cell wall & surface Score: 0.2795
  • Extracellular Score: 0.1762
• SignalP: no predicted signal peptide
  • SP(Sec/SPI): 0.405518
  • TAT(Tat/SPI): 0.014053
  • LIPO(Sec/SPII): 0.020374
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: WP_000073933 NCBI
• UniProt:

⊟Protein sequence

• MSNYRRTSKPKTEHIKKGFTVFQKTITTIGSILGLITAGITIMNALDNNNKNTKKEPTTSQTTTFVKEIQKESPQENTTPNKENNTSQEKTQQEETPKSSVKEEKKKDQKTATQDSTTPATSKPATENEKQPNTPTSENNTQ

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0775 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications