PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

NCBI: 24-APR-2024

⊟Summary

• organism: Streptococcus pneumoniae G54
• locus tag: SPG_RS04060 [old locus tag: SPG_0804 ]
• pan locus tag^?: PNEUPAN001836000
• symbol: SPG_RS04060
• pan gene symbol^?: —
• synonym:
• product: DUF6556 family protein

⊟Genome View

⊟Gene

⊟General

• type: CDS
• locus tag: SPG_RS04060 [old locus tag: SPG_0804 ]
• symbol: SPG_RS04060
• product: DUF6556 family protein
• replicon: chromosome
• strand: -
• coordinates: 778902..779330
• length: 429
• essential: unknown

⊟Accession numbers

• Location: NC_011072 (778902..779330) NCBI
• BioCyc: SPG_RS04060 BioCyc
• MicrobesOnline: see SPG_0804
• PneumoBrowse for strain D39V: SPV_0775 PneumoBrowse

⊟Phenotype

Share your knowledge and add information here. [edit]

⊟DNA sequence

• 1
  61
  121
  181
  241
  301
  361
  421
  
  ATGTCTAACTATCGTAGAACTTCAAAACCAAAAACAGAACACATCAAAAAAGGCTTTACA
  GTCTTTCAAAAAACCGTTGCTACAATCGCTAGTATCCTTGGCTTGATTACCGCAAGTATC
  ACGATTATGAACGCCTTGGATAATAACAAAAATATTAAAAAAGAACCTACGACAAGCCAG
  ACGACAACCANTGTCAAAGAAATCCAAAAGGAATCCCCTAAGGAAAACACCAGTCCAACT
  AAAGAGACTAACACTAGTCAAGAAAAAACACAGCAAGAGGAAACACCAAAATCTAGCGTC
  AAGGAAGAGAAAAAAGAAGATCAGAAAACAGCAACTCAGGACTCTTCTACTCCTGCTTCA
  AGTAAACCTGCTACTGAAAACGAAAAACAGTCCAATGCGCCAACTTCAGAAAATAAAAGC
  AATCAATAG
  60
  120
  180
  240
  300
  360
  420
  429
  

⊟Protein

⊟General

• locus tag: SPG_RS04060 [old locus tag: SPG_0804 ]
• symbol: SPG_RS04060
• description: DUF6556 family protein
• length: 142
• theoretical pI: 10.104
• theoretical MW: 15604.1
• GRAVY: -1.32766

⊟Function

• TIGRFAM:
  mobilome CxxCx(11)CxxC protein (TIGR04402; HMM-score: 17.1)
  and 6 more
  cobaltochelatase subunit (TIGR02442; EC 6.6.1.2; HMM-score: 12.2)
  integral membrane protein (TIGR04561; HMM-score: 9.1)
  Metabolism Energy metabolism TCA cycle dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex (TIGR01347; EC 2.3.1.61; HMM-score: 6.1)
  mycoides cluster lipoprotein, LppA/P72 family (TIGR03490; HMM-score: 5.6)
  Cellular processes Cellular processes Pathogenesis putative immunoglobulin-blocking virulence protein (TIGR04526; HMM-score: 5.5)
  pullulanase, extracellular (TIGR02102; HMM-score: 5.3)
• TheSEED: see SPG_0804
• PFAM:
  no clan defined DUF6556; Family of unknown function (DUF6556) (PF20193; HMM-score: 101.2)
  and 20 more
  Pep1_7; Elicitor peptide 1-7 (PF17232; HMM-score: 19.6)
  SGNH_hydrolase (CL0264) Lipase_GDSL_3; GDSL-like Lipase/Acylhydrolase family (PF14606; HMM-score: 14.5)
  no clan defined DUF6479; Family of unknown function (DUF6479) (PF20087; HMM-score: 14.3)
  MFS (CL0015) BT1; BT1 family (PF03092; HMM-score: 13)
  HTH (CL0123) DUF2551; Protein of unknown function (DUF2551) (PF10826; HMM-score: 12.7)
  no clan defined MotA_ExbB; MotA/TolQ/ExbB proton channel family (PF01618; HMM-score: 11.5)
  DUF3807; Protein of unknown function (DUF3807) (PF12720; HMM-score: 11.1)
  DMT (CL0184) Zip; ZIP Zinc transporter (PF02535; HMM-score: 10.9)
  no clan defined DUF5427; Family of unknown function (DUF5427) (PF10310; HMM-score: 8.5)
  GPCR_A (CL0192) SID-1_RNA_chan; dsRNA-gated channel SID-1 (PF13965; HMM-score: 8.2)
  no clan defined Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region (PF02932; HMM-score: 7.8)
  Ycf1; Ycf1 (PF05758; HMM-score: 7.5)
  RR_TM4-6; Ryanodine Receptor TM 4-6 (PF06459; HMM-score: 7.1)
  FAM220; FAM220 family (PF15487; HMM-score: 7.1)
  CDC45; CDC45-like protein (PF02724; HMM-score: 6.1)
  SLC12; Solute carrier family 12 (PF03522; HMM-score: 5.9)
  O-anti_assembly (CL0499) O-antigen_lig; O-antigen ligase like membrane protein (PF13425; HMM-score: 5.9)
  no clan defined Serinc; Serine incorporator (Serinc) (PF03348; HMM-score: 5.8)
  CIS_TMP; Contractile injection system tape measure protein (PF19268; HMM-score: 5.7)
  Peptidase_AD (CL0130) Presenilin; Presenilin (PF01080; HMM-score: 5.6)

⊟Structure, modifications & cofactors

• domains:
• modifications:
• cofactors:
• effectors:

⊟Localization

• PSORTb: unknown (no significant prediction)
  • Cytoplasmic Score: 2.5
  • Cytoplasmic Membrane Score: 2.5
  • Cellwall Score: 2.5
  • Extracellular Score: 2.5
  • Internal Helix: 1
• DeepLocPro: Cytoplasmic Membrane
  • Cytoplasmic Score: 0.0097
  • Cytoplasmic Membrane Score: 0.4655
  • Cell wall & surface Score: 0.3155
  • Extracellular Score: 0.2094
• SignalP: Signal peptide SP(Sec/SPI) length 45 aa
  • SP(Sec/SPI): 0.578193
  • TAT(Tat/SPI): 0.020354
  • LIPO(Sec/SPII): 0.013807
  • Cleavage Site: CS pos: 45-46. MNA-LD. Pr: 0.4894
• predicted transmembrane helices (TMHMM): 1

⊟Accession numbers

• GI:
• RefSeq: WP_000073939 NCBI
• UniProt:

⊟Protein sequence

• MSNYRRTSKPKTEHIKKGFTVFQKTVATIASILGLITASITIMNALDNNKNIKKEPTTSQTTTXVKEIQKESPKENTSPTKETNTSQEKTQQEETPKSSVKEEKKEDQKTATQDSSTPASSKPATENEKQSNAPTSENKSNQ

⊟Experimental data

• protein localization:
• interaction partners:

⊟Expression & Regulation

⊟Operon

• MicrobesOnline: no polycistronic organisation predicted

⊟Regulation

• regulator:

⊟Transcription

• transcription start site:

⊟Expression data

• PneumoExpress for strain D39V: SPV_0775 PneumoExpress

⊟Biological Material

⊟Mutants

⊟Expression vector

⊟lacZ fusion

⊟GFP fusion

⊟two-hybrid system

⊟FLAG-tag construct

⊟Antibody

⊟Other Information

You can add further information about the gene and protein here. [edit]

⊟Literature

⊟References

⊟Relevant publications