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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 07-MAR-2025

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hu17
  • locus tag: SPNHU17_RS04275 [old locus tag: SPNHU17_00924 ]
  • pan locus tag?: PNEUPAN001836000
  • symbol: SPNHU17_RS04275
  • pan gene symbol?: —
  • synonym:
  • product: DUF6556 family protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPNHU17_RS04275 [old locus tag: SPNHU17_00924 ]
  • symbol: SPNHU17_RS04275
  • product: DUF6556 family protein
  • replicon: chromosome
  • strand: -
  • coordinates: 853809..854243
  • length: 435
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP020549 (853809..854243) NCBI
  • BioCyc: SPNHU17_RS04275 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0775 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGTCTAATTATCGTAGAACTTCAAAACCAAAAACAGAACACATCAAAAAAGGCTTTACA
    GTCTTTCAAAAAACCGTTGCGACTATCGCTAGTATCCTTGGCTTGATTACCGCTAGTATC
    ACGATTATGAACGCCTTGGATAATAACAAAAATACTAAAAAGGAACCTACAACAAGCCAG
    ACGACAACAATTGTCAAAGAAATTCAAAAGGAATCCCCTCAGGAAAATACTAGTCCCAAT
    AAGGAAAATAAGACTTCTCAAGAAAAAACACAACAAGAAGAAACGCCAAAATCCAGCGTC
    AAGGAAGAGAAAAAAGAAGAGCAGAAAACATCAACTCAGGATTCTTCTACTCCTGCTCCT
    ACTCCAAGTAAACCTGCTACTGAAAACGAAAAACAGTCCAATACCCCAACTTCGGAAAAT
    AAAACTAATCAATAA
    60
    120
    180
    240
    300
    360
    420
    435

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPNHU17_RS04275 [old locus tag: SPNHU17_00924 ]
  • symbol: SPNHU17_RS04275
  • description: DUF6556 family protein
  • length: 144
  • theoretical pI: 10.104
  • theoretical MW: 16027.6
  • GRAVY: -1.4

⊟Function[edit | edit source]

  • TIGRFAM:
    mobilome CxxCx(11)CxxC protein (TIGR04402; HMM-score: 16.8)
    and 8 more
    cobaltochelatase subunit (TIGR02442; EC 6.6.1.2; HMM-score: 12.8)
    Genetic information processing Transcription Degradation of RNA ribonuclease Y (TIGR03319; EC 3.1.-.-; HMM-score: 9)
    Metabolism Biosynthesis of cofactors, prosthetic groups, and carriers Heme, porphyrin, and cobalamin cobaltochelatase, CobT subunit (TIGR01651; EC 6.6.1.2; HMM-score: 8.3)
    Cellular processes Cellular processes Pathogenesis putative immunoglobulin-blocking virulence protein (TIGR04526; HMM-score: 6.5)
    mycoides cluster lipoprotein, LppA/P72 family (TIGR03490; HMM-score: 6.3)
    pullulanase, extracellular (TIGR02102; HMM-score: 5.7)
    integral membrane protein (TIGR04561; HMM-score: 4.6)
    Metabolism Energy metabolism TCA cycle dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex (TIGR01347; EC 2.3.1.61; HMM-score: 4.3)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined DUF6556; Family of unknown function (DUF6556) (PF20193; HMM-score: 104)
    and 25 more
    Pep1_7; Elicitor peptide 1-7 (PF17232; HMM-score: 19.6)
    MFS (CL0015) BT1; BT1 family (PF03092; HMM-score: 14.9)
    HTH (CL0123) DUF2551; Protein of unknown function (DUF2551) (PF10826; HMM-score: 13.8)
    SGNH_hydrolase (CL0264) Lipase_GDSL_3; GDSL-like Lipase/Acylhydrolase family (PF14606; HMM-score: 13.1)
    DMT (CL0184) Zip; ZIP Zinc transporter (PF02535; HMM-score: 12.7)
    no clan defined MotA_ExbB; MotA/TolQ/ExbB proton channel family (PF01618; HMM-score: 12.2)
    Ycf1; Ycf1 (PF05758; HMM-score: 9.8)
    O-anti_assembly (CL0499) O-antigen_lig; O-antigen ligase like membrane protein (PF13425; HMM-score: 9.5)
    no clan defined Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region (PF02932; HMM-score: 9.4)
    Miga; Mitoguardin (PF10265; HMM-score: 9.1)
    GPCR_A (CL0192) SID-1_RNA_chan; dsRNA-gated channel SID-1 (PF13965; HMM-score: 9.1)
    GT-B (CL0113) FUT8_N_cat; Alpha-(1,6)-fucosyltransferase N- and catalytic domains (PF19745; HMM-score: 8.5)
    no clan defined vMSA; Major surface antigen from hepadnavirus (PF00695; HMM-score: 8)
    Serinc; Serine incorporator (Serinc) (PF03348; HMM-score: 8)
    MPDZ_u10; Unstructured region 10 on multiple PDZ protein (PF16667; HMM-score: 7.8)
    Shisa; Wnt and FGF inhibitory regulator (PF13908; HMM-score: 7.7)
    DUF5427; Family of unknown function (DUF5427) (PF10310; HMM-score: 7.6)
    CIS_TMP; Contractile injection system tape measure protein (PF19268; HMM-score: 7.4)
    RR_TM4-6; Ryanodine Receptor TM 4-6 (PF06459; HMM-score: 6.9)
    DDHD; DDHD domain (PF02862; HMM-score: 6.4)
    MFS (CL0015) CLN3; CLN3 protein (PF02487; HMM-score: 6.3)
    AhpD-like (CL0423) PA26; PA26 p53-induced protein (sestrin) (PF04636; HMM-score: 5.6)
    Peptidase_AD (CL0130) Presenilin; Presenilin (PF01080; HMM-score: 5.4)
    no clan defined SLC12; Solute carrier family 12 (PF03522; HMM-score: 5.4)
    DUF4551; Protein of unknown function (DUF4551) (PF15087; HMM-score: 5)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • DeepLocPro: Cell wall & surface
    • Cytoplasmic Score: 0.0112
    • Cytoplasmic Membrane Score: 0.3913
    • Cell wall & surface Score: 0.432
    • Extracellular Score: 0.1656
  • SignalP: Signal peptide SP(Sec/SPI) length 45 aa
    • SP(Sec/SPI): 0.57298
    • TAT(Tat/SPI): 0.023284
    • LIPO(Sec/SPII): 0.017124
    • Cleavage Site: CS pos: 45-46. MNA-LD. Pr: 0.4813
  • predicted transmembrane helices (TMHMM): 1

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000073945 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MSNYRRTSKPKTEHIKKGFTVFQKTVATIASILGLITASITIMNALDNNKNTKKEPTTSQTTTIVKEIQKESPQENTSPNKENKTSQEKTQQEETPKSSVKEEKKEEQKTSTQDSSTPAPTPSKPATENEKQSNTPTSENKTNQ

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Transcription[edit | edit source]

  • transcription start site:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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