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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 09-FEB-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae 6A-10
  • locus tag: HKM25_RS02435 [old locus tag: HKM25_494 ]
  • pan locus tag?: PNEUPAN001382000
  • symbol: HKM25_RS02435
  • pan gene symbol?: endoD
  • synonym:
  • product: bacterial Ig-like domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: HKM25_RS02435 [old locus tag: HKM25_494 ]
  • symbol: HKM25_RS02435
  • product: bacterial Ig-like domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 464721..469697
  • length: 4977
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NZ_CP053210 (464721..469697) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0444 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
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    481
    541
    601
    661
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    1021
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    1381
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    1681
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    2041
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    3001
    3061
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    3181
    3241
    3301
    3361
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    4441
    4501
    4561
    4621
    4681
    4741
    4801
    4861
    4921
    ATGAAGAATCCATTTTTTGAAAGACGTTGTCGTTACAGTATTCGTAAGTTATCAGTAGGA
    GCCTGCTCGCTGATGATTGGTGCTGTTTTATTTGCTGGTCCAGCCTTGGCTGAAGAAACT
    GCAGTTCCTGAAAATAGCGGAGCTAATACAGAGCTTGTTTCAGGAGAGAGTGAGCATTCG
    ACCAATGAAGCTGATAAGCAGAATGAAGGGGAACATACTAGAGAAAACAAGCTAGAAAAG
    GCAGAAGGAGTAGCGACAGCATCTGAAACTGCAGAAGCAGCTAGCGCAGCTAAACCAGAG
    GAAAAAGCAAGTGAGGTGGTTGCAGAAACACCATCTGCAGAAGCAAAACCTAAGTCTGAC
    AAGGAAACAGAAGCAAAGCCCGAAGCAACTAACCAAGGGGATGAGTCTAAGCCAGCAGCC
    GAAGCTAATAAGACTGAAAAAGAAGTCCAGCCAGATGTCCCTAAAAATACAGAAAAAACA
    TTAAAACCAAAGGAAATCAAATTTAATTCTTGGGAAGAATTGTTAAAATGGGAACCAGGT
    GCTCGTGAAGATGATGCTATTAACCGCGGATCTGTTGTCCTCGCTTCACGTCGGACAGGT
    CATTTAGTCAATGAAAAAGCTAGCAAGGAAGCAAAAGTTCAAGCCTTATCAAACACCAAT
    TCTAAAGCAAAAGACCATGCTTCTGTTGGTGGAGAAGAGTTCAAGGCCTATGCTTTTGAC
    TATTGGCAATATCTAGATTCAATGGTCTTCTGGGAAGGTCTCGTACCAACTCCTGACGTT
    ATTGATGCAGGTCACCGTAACGGGGTTCCTGTATACGGTACACTCTTCTTCAACTGGTCT
    AATAGTATTGCAGATCAAGAAAGATTTGCTGAAGCTTTGAAGCAAGACGCAGATGGTAGC
    TTCCCAATTGCCCGTAAATTGGTAGACATGGCAAAGTATTATGGCTATGATGGCTATTTC
    ATCAACCAAGAAACAACTGGAGATTTGGTTAAACCTCTTGGAGAAAAGATGCGCCAGTTT
    ATGCTCTATAGCAAGGAATATGCTGCCAAGGTAAACCATCCAATCAAGTATTCTTGGTAT
    GATGCCATGACCTATAACTATGGACGTTACCATCAAGATGGTTTGGGAGAATACAACTAC
    CAATTCATGCAACCAGAAGGAGATAAGGTTCCGGTAGATAACTTCTTTGCTAACTTTAAC
    TGGGATAAGGCTAAAAATGATTACACTATTGCAACTGCCAACTGGATTGGTCGTAATCCT
    TATGATGTATTTGCAGGTTTGGAATTGCAACAGGGTGGTTCCTACAAGACAAAGGTTAAG
    TGGAATGACATTTTAGACGAAAATGGGAAATTGCGCCTTTCTCTTGGTTTATTTGCCCCA
    GATACCATTACAAGTTTAGGAAAAACTGGTGAAGATTATCATAAAAATGAAGATATCTTC
    TTTACAGGTTATCAAGGAGACCCTACTGGCCAAAAACCAGGTGACAAAGATTGGTATGGT
    ATTGCTAACCTAGTTGCGGACCGTACGCCAGCGGTAGGTAATACTTTTACTACTTCTTTT
    AATACAGGTCATGGTAAAAAATGGTTCGTAGATGGTAAGGTTTCTAAGGATTCTGAGTGG
    AATTATCGTTCAGTATCAGGTGTTCTTCCAACATGGCGCTGGTGGCAGACTTCAACAGGG
    GAAAAACTTCGTGCAGAATATGATTTTACAGATGCCTATAATGGCGGAAATTCCCTTAAA
    TTCTCTGGTGATGTAGCCGGTAAGACAGATCAGGATGTGAGACTTTATTCTACTAAGTTA
    GAAGTAACTGAGAAGACCAAACTTCGTGTTGCCCACAAGGGAGGAAAAGGTTCTAAAGTT
    TATATGGCATTCTCTACAACTCCAGACTACAAATTCGATGATGCAGATGCATGGAAAGAG
    CTAACCCTTTCTGACAACTGGACAAATGAAGAATTTGATCTTAGCTCACTAGCGGGTAAA
    ACCATCTATGCAGTCAAACTATTTTTCGAGCATGAAGGTGCTGTAAAAGATTATCAGTTC
    AACCTAGGACAATTAACTATCTCGGACAATCACCAAGAGCCACAATCGCCGACAAGCTTT
    TCTGTAGTGAAACAATCGCTTAAAAATGCCCAAGAAGCGGAAGCAGTTGTGCAATTTAAA
    GGCAACAAGGATGCAGATTTCTATGAAGTTTATGAAAAAGATGGAGACAACTGGAAATTA
    CTAACTGGCTCATCTTCTACAACTATTTATCTACCAAAAGTTAGCCGCTCAGCAAGTGCT
    CAGGGTACAACTCAAGAACTGAAGGTTGTAGCAGTCGGTAAAAATGGAGTTCGTTCAGAA
    GCTGCAACCACAACCTTTGATTGGGGTATGACTGTAAAAGATACCAGCCTACCAAAACCA
    CTAGCTGAAAATATCGTTCCAGGTGCAACAGTTATTGATAGTACTTTCCCTAAGACTGAA
    GGTGGAGAAGGTATTGAAGGTATGTTGAACGGTACCATTACTAGCTTGTCAGATAAATGG
    TCTTCAGCTCAGTTGAGTGGTAGTGTGGATATTCGTTTGACCAAGCCACGTACCGTTGTT
    AGATGGGTCATGGATCATGCAGGAGCTGGTGGTGAGTCTGTTAACGATGGCTTGATGAAC
    ACCAAAGACTTTGACCTTTATTATAAAGATGCAGATGGTGAGTGGAAGCTAGCTAAGGAA
    GTCCGTGGTAACAAAGCACACGTGACAGATGTCACTCTTGATAAACCAATCACTGCTCAA
    GACTGGCGCTTGAATGTTGTCACTTCTGACAATGGAACTCCATGGAAGGCTATTCGTATC
    TATAACTGGAAAATGTATGAAAAGCTTGATACTGAGAGTGTCAATATTCCGATGGCCAAG
    GCTGCAGCCCGTTCTCTAGGCAATAACAAGGTACAAGTTGGCTTTGCAGATGTACCGGCT
    GGAGCAACTATTACCGTTTATGATAATCCAAATTCTCAAACTCCGCTTGCAACCTTGAAG
    AGCGAAGTTGGAGGAGACCTAGCAAGTGCACCATTGGATTTGACAAATCAATCTGGTCTT
    CTTTATTATCGTACCCAGTTGCCAGGCAAGGAAATTAGTAATGTCCTAGCAGTTTCCGTT
    CCAAAAGATGACAGAAGAATCAAGTCAGTCAGCCTAGAAACAGGACCTAAGAAAACAAGC
    TACGCCGAAGGGGAGGATTTGGACCTTAGAGGTGGTGTTCTTCGAGTTCAGTATGAAGGA
    GGAACTGAGGACGAACTCATTCGCCTAACTCACGCAGGTGTATCAGTATCAGGTTTTGAT
    ACGCATCATAAGGGAGAACAGAATCTTACTCTCCAATATTTGGGACAACCGGTAAATGCT
    AATTTGTCAGTGACTGTCACTGGCCAAGACGAAGCAAGTCCGAAAACTATTTTGGGAATT
    GAAGTAAGTCAGGAACCGAAAAAAGATTACCTAGTTGGTGATAGCTTAGACTTGTCTGAA
    GGACGCTTTGCAGTGGCTTATAGCAATGACACCATGGAAGAACATTCCTTTACTGATGAG
    GGAGTTGAAATTTCTGGTTACGATGCTCAAAAGACTGGTCGTCAAACCTTGACGCTTCGT
    TACCAAGGTCATGAAGTCAACTTTGATGTTTTGGTATCTCCAAAAGCAGCATTGAACGAT
    GAGTACCTCAAACAAAAATTAGCAGAAGTTGAAACTGCTAAGAACAAGGTGGTCTATAAC
    TTTGCTTCACCAGAAGTAAAAGAAGCCTTCTTGAAAGCAATTGAAGCGGCCGAACAAGTG
    TTGAAAGACCATGAAACTAGCACCCAAGATCAGGTTAATGACCGACTTAATAAATTGACA
    GAAGCTCATAAAGCTCTGAATGGACAAGAGAAATTTACGGAAGAAAAGACAGAACTCGAT
    CGCTTAACAAGTGAGGCTCAAGAACTTTTAGCTTCAAAACCAAACCATCCTTCAGGTTCC
    GCCCTAGCTCCACTTCTTGAGAAGAACAAGGCCTTGGTTGAAAAAGTAGATTTGAGTCCA
    GAAGAGCTTGCAACAGCGAAACAGAGTCTGAAAGATCTGGTTGCCTTATTGAAAGAAGAC
    AAGCCAGCAGTCTTTTCTGATAGTAAAACAGGTGTTGAAGTACACTTCTCAAATAAAGAG
    AAGACTGTCATCAAGGGCTTGAAAGTAGAGCGTGTTCAAGCAAGTGATGAAGAGAAGAAA
    TACTTTGCTGGAGAAGATGGTCATGTCTTTGAAATAGAAGGTTTAGATGAAAAAGGTCAA
    GACGTTGATCTCTCTTACGCTTCTATTGTGAAAATTCCAATTGAAAAAGATAAGAAAGTG
    AAGAAAGTCTTCTTCTTACCTGAAGGAAAAGCAGCAGTAGAATTGGCTTTTGAACAAACG
    GATAGTCATGTCATCTTTACAGCACCACACTTTACTCATTATGCCTTTGTTTATGAATCT
    GCTGAGAAACCACGAGTAGAATCTAATGGTGCAAATGACCTTGTTACTATCTCAACTAAA
    CCAGAACAACAAAACACAGTCCTTCCAAAAACTACTAATCAACCGGCTTCTGATCAACAA
    AAGGCTCCTAAATTGGAAGTTCAAGAGGAAAAGGTTGCCTTTGACCGTCAAGAGCATGAA
    AATGCTGAGATGCTAGTTGGGGAACAACGAGTCATCATACAGGGACGAGATGGTCTGTTG
    AGACATGTCTTTGAAGTTGATGAAAACGGTCAGCGTCGTCTTCGTTCAACAGAAGTCATC
    CAAGAAGCGATTCCAGAAATTGTTGAAATTGGAACAAAAGTAAAAACAGTACTAGCAGTA
    GTAGCTACACAGGAAAAACCAGCTCAAAATACAGCAGTTAAATCAGAAGAAGCAAGCAAA
    CAATTGCCAAATACAGGAACAGCTGATGCTAATGAAGCCCTAATAGCAGGCTTAGCCAGC
    CTTGGTCTTGCTAGTTTAGCCTTGACCTTGAGACGGAAAAGAGAAGATAAAGATTAA
    60
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    4800
    4860
    4920
    4977

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: HKM25_RS02435 [old locus tag: HKM25_494 ]
  • symbol: HKM25_RS02435
  • description: bacterial Ig-like domain-containing protein
  • length: 1658
  • theoretical pI: 4.92568
  • theoretical MW: 183315
  • GRAVY: -0.628709

⊟Function[edit | edit source]

  • TIGRFAM:
    gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 48.8)
    and 2 more
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 23.8)
    conserved hypothetical protein (TIGR01741; HMM-score: 11.5)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    Glyco_hydro_tim (CL0058) Glyco_hydro_85; Glycosyl hydrolase family 85 (PF03644; HMM-score: 244.2)
    and 7 more
    E-set (CL0159) Big_3; Bacterial Ig-like domain (group 3) (PF07523; HMM-score: 122.7)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 47.4)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 41.3)
    B_GA (CL0598) FIVAR; FIVAR domain (PF07554; HMM-score: 26.4)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 23.7)
    PepSY (CL0320) PepSY_2; Peptidase propeptide and YPEB domain (PF13670; HMM-score: 12.2)
    no clan defined Spectrin; Spectrin repeat (PF00435; HMM-score: 8.7)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0.01
    • Cytoplasmic Membrane Score: 0.01
    • Cellwall Score: 9.97
    • Extracellular Score: 0.01
    • Internal Helices: 0
  • SignalP: Signal peptide SP(Sec/SPI) length 37 aa
    • SP(Sec/SPI): 0.988399
    • TAT(Tat/SPI): 0.009607
    • LIPO(Sec/SPII): 0.001087
    • Cleavage Site: CS pos: 37-38. ALA-EE. Pr: 0.9835
  • predicted transmembrane helices (TMHMM): 0

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000795208 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MKNPFFERRCRYSIRKLSVGACSLMIGAVLFAGPALAEETAVPENSGANTELVSGESEHSTNEADKQNEGEHTRENKLEKAEGVATASETAEAASAAKPEEKASEVVAETPSAEAKPKSDKETEAKPEATNQGDESKPAAEANKTEKEVQPDVPKNTEKTLKPKEIKFNSWEELLKWEPGAREDDAINRGSVVLASRRTGHLVNEKASKEAKVQALSNTNSKAKDHASVGGEEFKAYAFDYWQYLDSMVFWEGLVPTPDVIDAGHRNGVPVYGTLFFNWSNSIADQERFAEALKQDADGSFPIARKLVDMAKYYGYDGYFINQETTGDLVKPLGEKMRQFMLYSKEYAAKVNHPIKYSWYDAMTYNYGRYHQDGLGEYNYQFMQPEGDKVPVDNFFANFNWDKAKNDYTIATANWIGRNPYDVFAGLELQQGGSYKTKVKWNDILDENGKLRLSLGLFAPDTITSLGKTGEDYHKNEDIFFTGYQGDPTGQKPGDKDWYGIANLVADRTPAVGNTFTTSFNTGHGKKWFVDGKVSKDSEWNYRSVSGVLPTWRWWQTSTGEKLRAEYDFTDAYNGGNSLKFSGDVAGKTDQDVRLYSTKLEVTEKTKLRVAHKGGKGSKVYMAFSTTPDYKFDDADAWKELTLSDNWTNEEFDLSSLAGKTIYAVKLFFEHEGAVKDYQFNLGQLTISDNHQEPQSPTSFSVVKQSLKNAQEAEAVVQFKGNKDADFYEVYEKDGDNWKLLTGSSSTTIYLPKVSRSASAQGTTQELKVVAVGKNGVRSEAATTTFDWGMTVKDTSLPKPLAENIVPGATVIDSTFPKTEGGEGIEGMLNGTITSLSDKWSSAQLSGSVDIRLTKPRTVVRWVMDHAGAGGESVNDGLMNTKDFDLYYKDADGEWKLAKEVRGNKAHVTDVTLDKPITAQDWRLNVVTSDNGTPWKAIRIYNWKMYEKLDTESVNIPMAKAAARSLGNNKVQVGFADVPAGATITVYDNPNSQTPLATLKSEVGGDLASAPLDLTNQSGLLYYRTQLPGKEISNVLAVSVPKDDRRIKSVSLETGPKKTSYAEGEDLDLRGGVLRVQYEGGTEDELIRLTHAGVSVSGFDTHHKGEQNLTLQYLGQPVNANLSVTVTGQDEASPKTILGIEVSQEPKKDYLVGDSLDLSEGRFAVAYSNDTMEEHSFTDEGVEISGYDAQKTGRQTLTLRYQGHEVNFDVLVSPKAALNDEYLKQKLAEVETAKNKVVYNFASPEVKEAFLKAIEAAEQVLKDHETSTQDQVNDRLNKLTEAHKALNGQEKFTEEKTELDRLTSEAQELLASKPNHPSGSALAPLLEKNKALVEKVDLSPEELATAKQSLKDLVALLKEDKPAVFSDSKTGVEVHFSNKEKTVIKGLKVERVQASDEEKKYFAGEDGHVFEIEGLDEKGQDVDLSYASIVKIPIEKDKKVKKVFFLPEGKAAVELAFEQTDSHVIFTAPHFTHYAFVYESAEKPRVESNGANDLVTISTKPEQQNTVLPKTTNQPASDQQKAPKLEVQEEKVAFDRQEHENAEMLVGEQRVIIQGRDGLLRHVFEVDENGQRRLRSTEVIQEAIPEIVEIGTKVKTVLAVVATQEKPAQNTAVKSEEASKQLPNTGTADANEALIAGLASLGLASLALTLRRKREDKD

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

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