⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae INV104
- locus tag: INV104_09960 [new locus tag: INV104_RS05770 ]
- pan locus tag?: PNEUPAN002295000
- symbol: zmpA
- pan gene symbol?: zmpA
- synonym: iga
- product: IgA-protease
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS
- locus tag: INV104_09960 [new locus tag: INV104_RS05770 ]
- symbol: zmpA
- product: IgA-protease
- replicon: chromosome
- strand: +
- coordinates: 1089856..1095747
- length: 5892
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: FQ312030 (1089856..1095747) NCBI
- BioCyc: see INV104_RS05770
- MicrobesOnline:
- PneumoBrowse for strain D39V:
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
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5881ATGGAAAAGTATTTTGGTGAAAAACAAGAGCGTTTTTCATTTAGAAAATTATCAGTAGGA
CTTGTATCTGCAACGATTTCAAGTTTATTTTTTATGTCTGTATTAGCTAGTTCATCTGTG
GATGCTCAAGAAACTGCGGGAGTTCACTATAAATATGTGGCAGATTCAGAGCTATCATCA
GAAGAAAAGAAGCAGCTTGTCTATGATATTCCGACATACGTGGAGAATGATGATGAAACT
TATTATCTTGTTTATAAGTTAAATTCTCAAAATCAACTGGCGGAATTACCAAATACTGGA
AGCAAGAATGAGAGGCAAGCCCTAGTTGCTGGTGCTAGCTTAGCTGCTCTGGGAATTTTA
ATTTTTGCTGTTTCCAAGAAAAAGGTTAAGAATAAAACGGTATTACATTTAGTATTGGTT
GCGGGAATGGGAAATGGTGTCTTAGTTTCAGTCCATGCTTTAGAAAATCATCTTTTGCTA
AATTACAATACGGACTATGAATTGACCTCTGGAGAAAAATTACCTCTTCCTAAAGAGATT
TCAGGTTACACTTATATTGGATATATCAAAGAGGGAAAAACGACTTCTGATTTTGAAGTA
AGTAATCAAGAAAAATCAGCAGCCACTCCTACAAAACAACAAAAGGTGGATTATAATGTT
ACACCAAATTTTGTAGACCATCCATCAACAGTACAAGCTATTCAGGAACAAACACCTGTT
TCTTCAACTAAGCCGACAGAAGTTCAAGTAGTTGAAAAACCTTTCTCTACTGAATTAATC
AATCCAAGAAAAGAAGAGAAACAATCTTCAGATTCTCAAGAACAATTAGCCGAACATAAG
AATCTAGAAACGAAGAAAGAGGAGAAGATTTCTCCAAAAGAAAAGACTGGGGTAAATACA
TTAAATCCACAGGATGAAGTTTTATCAGGTCAATTGAACAAACCTGAACTCTTATATCGT
GAGGAAACTATAGAGACAAAAATAGATTTTCAAGAAGAAATTCAAGAAAATCCTGATTTA
GCTGAAGGAACTGTAAGAGTAAAACAAGAAGGTAAATTAGGTAAGAAAGTTGAAATCGTC
AGAATATTCTCTGTAAACAAGGAAGAAGTTTCGCGAGAAATTGTTTCAACTTCAACGACT
GCGCCTAGTCCAAGAATAGTCGAAAAAGGTACTAAAAAAACTCAAGTTATAAAGGAACAA
CCTGAGACTGGTGTAGAACATAAGGACGTACAGTCTGGATCTATTGTTGAACCCGCAATT
CAGCCTGAGTTGCCCGAAGCTGTAGTAAGTGATAAAGGCGAACCAGAAGTTCAACCGACA
TTACCCGAAGCAGTTGTGACCGACAAAGGTGAGACTGAGGTTCAACCAGAGTCGCCAGAT
ACTGTGGTAAGTGATAAAGGTGAACCAGAGCAGGTAGCCCCATTGCCAGAATATAAGGGT
AATATTGAGCAAGTAAAACCTGAAACTCCGGTTGAGAAGACCAAAGAACAAGGTCCAGAA
AAAACTGAAGAAGTTCCAGTAAAACCAACAGAAGAAACACCAGTAAATCCAAATGAAGGT
ACTACAGAAGGAACCTCAATTCAAGAAGCAGAAAATCCAGTTCAACCTGCAGAAGAATCA
ACAACGAATTCAGAGAAAGTATCACCAGATACATCTAGCGAAAATACTGGGGAAGTGTCC
AGTAATCCTAGTGATTCGACAACCTCAGTTGGAGAATCAAATAAACCAGAACATAATGAC
TCTAAAAATGAAAATTCAGAAAAAACTGTAGAAGAAGTTCCAGTAAATCCAAATGAAGGC
ACAGTAGAAGGTACCTCAAATCAAGAAACAGAAAAACCAGTTCAACCTGCAGAAGAAACA
CAAACAAACTCTGGGAAAATAGCTAACGAAAATACTGGAGAAGTATCCAATAAACCTAGT
GATTCAAAACCACCAGTTGAAGAATCAAATCAACCAGAAAAAAACGGAACTGCAACAAAA
CCAGAAAATTCAGGTAATACAACATCAGAGAATGGACAAACAGAACCAGAGAAAAAACTC
GAATTAAGAAATGTTTCTGATATTGAGTTGTATAGTCAGACGAATGGAACCTACAGACAA
CATGTTTCATTGGATGGAATTCCAGAGAATACGGATACTTACTTTGTCAAGGTAAAATCT
TCAGCATTTAAAGATGTCTATATACCAGTAGCTTCAATAACTGAAGAGAAAAGAAATGGG
CAGTCAGTTTATAAAATCACAGCCAAAGCTGAGAAACTCCAGCAAGAACTAGAAAATAAA
TATGTCGACAATTTCACCTTCTACCTCGATAAGAAGGCTAAAGAGGAAAATACAAACTTT
ACTTCCTTTAGCAACCTGGTCAAAGCTATAAACCAAAATCCCTCTGGAACCTATCATTTA
GCGGCCAGCCTGAATGCTAACGAAGTGGAGCTTGGTCCTGATGAAAGATCCTATATCAAG
GACACCTTTACTGGTCGTTTAATCGGTGAAAAAGATGGCAAGAATTATGCTATCTATAAT
TTGAAAAAACCTCTGTTTGAAAACTTGAGTGGTGCTACAGTAGAAAAACTGAGTCTAAAA
AATGTTGCTATTTCAGGGAAAAATGATATTGGTTCACTAGCAAATGAAGCTACGAATGGC
ACAAAGATTAAACAAGTTCATGTTGATGGTGTTCTGGCTGGAGAACGTGGTGTCGGTGGT
TTGTTGGCTAAGGCAGACCAATCAAGCATCGCAGAGAGCAGTTTCAAGGGAAGAATTGTC
AATACCTATGAAACGACTGATGCCTACAATATTGGCGGTCTGGTCGGTCATTTAACAGGA
AAAAATGCGTCTATTGCTAAATCCAAAGCGACAGTAACCATTTCGTCAAACACCAATAGG
TCAGATCAGACTGTCGGTGGTCTTGCAGGTCTAGTAGACCAAGATGCGCATATACAGAAC
AGTTATGCGGAAGGTGATATTAATAATGTCAAGCACTTTGGTAAAGTCGCTGGTGTGGCA
GGATATTTGTGGGATCGAACTTCTGGTGAGGAAAAACACGCTGGTGAATTGACCAATGTT
CTTAGCGATGTCAATGTAACAAACGGAAATGCCATCACTGGATACCACTATACAGGAATG
AAGGTAGCTAATACATTTAGTAGTAAGGCTAATAGAGTTTTCAATGTCACTTTAGAGAAG
GATGAGGTCGTCAGCAAGGAATCCTTTGAAGAAAGAGGAACAATGCTAGATGCTTCTCAA
ATTGTAAGCAAAAAAGCAGAAATAAATCCTCTCACTCTACCAACGGTGGAACCCCTCTCA
ACAAGTGGCAAGAAAGACAGTGATTTTTCTAAGATAGCCCATTATCAAGCTAACCGTGCT
TTGGTTTATAAGAACATTGAAAAATTGTTACCTTTTTATAATAAGTCAACCATCGTCAAA
TACGGAAACCTGGTTAAGGAGAACAGTCTCTTATACCAAAAAGAACTCTTATCTGCAGTT
ATGATGAAGGATGACCAAGTAATCACAGATATTGTTTCCAACAAACAGACTGCAAACAAA
CTCTTACTTCACTATAATGACCATTCATCTGAGAAATTTGATCTCAAGTACCAGACTGAT
TTTGCCAATCTAGCAGAATATAATCTAGGTAATACGGGACTTCTCTACACTCCTAACCAA
TTCTTATATGATCGAGACTCTATTGTTAAGGAAGTCTTGCCTGAGTTGCAGAAGCTTGAT
TACCAGTCAGATGCTATCAGAAAGACACTTGGTATTTCTCCAGAAGTTAAGTTAACCGAG
CTCTATTTAGAAGACCAGTTCTCCAAAACAAAACAAAATCTGGGAGACAGCTTGAAAAAA
CTTTTGTCAGCAGATGCCGGTCTAGCTAGCGATAACTCAGTCACCAGAGGCTATCTTGTA
GATAAAATCAAGAATAATAAGGAAGCCTTGCTACTCGGTTTAACTTATTTAGAACGTTGG
TATAACTTTAACTATGGTCAAGTGAATGTCAAAGACCTAGTTATGTATCATCCAGACTTC
TTTGGTAAAGGAAATACTTCCCCACTAGATACTCTGATTGAGTTAGGTAAATCTGGCTTT
AACAATCTTCTAGCTAAGAATAATGTCGATACTTATGGTATCAGTCTTGCCAGTCAACAT
GGAACGACAGATTTGTTTAGCACGCTGGAACATTACCGAAAAGTCTTTTTACCAAATACA
AGCAATAATGACTGGTTTAAATCAGAGACTAAGGCTTACATTGTCGAAGAAAAATCCACT
ATCGAAGAGGTGAAAACGAAGCAAGGGTTAGCTGGCACCAAGTATTCTATCGGTGTTTAT
GATCGTATCACGAGTGCCACATGGAAATACCGCAATATGGTCTTGCCTCTCCTGACCTTG
CCAGAGAGATCCGTATTTGTCATCTCGACCATGTCTAGTCTAGGATTTGGAGCTTATGAT
CGCTACCGCAGTAGTGACCATAAAGCGGGCAAGGCTCTCAATGATTTTGTTGAAGAAAAT
GCGCGTGAAACAGCCAAACGTCAGCGAGATCACTACGATTATTGGTATCGTATTTTAGAT
GAACAGTCACGCGAAAAACTCTATCGTACGATTCTCCTTTATGATGCCTATAAGTTTGGG
GATGACACAACATCAGGAAAAGCTACAGCGGAGGCTAAGTTTGATAGCTCCAATCCAGCT
ATGAAGAACTTCTTTGGACCAGTTGGCAATAAGGTAGTACACAACCAGCATGGAGCCTAC
GCTACAGGGGACGGCGTCTACTATATGTCTTACCGCATGCTGGACAAGGATGGAGCCATT
ACTTATACCCATGAAATGACCCATGATTCGGATCAGGATATTTACCTTGGTGGCTATGGT
CGAAGAAATGGCTTGGGACCAGAGTTCTTCGCAAAAGGCTTATTGCAAGCCCCTGACCAA
CCAAGTGACGCAACCATTACCATTAATTCTATCTTGAAACACTCAAAATCAGATAGTACA
GAGGGATCCCGTCTTCAAGTCTTGGATCCGACAGAGAGATTCCAAAACGCAGCAGATCTT
CAGAACTATGTCCATAACATGTTTGACCTTATCTACATGATGGAATATCTCGAAGGGCAG
TCAATCGTTAATAAACTAAGTGTTTACCAGAAAATGGCGGCTCTCAGAAAAATTGAGAAC
AAGTATGTGAAAGATCCAGCAGATGGAAATGAGGTTTATGCCACTAACGTAGTCAAAGAA
TTGACAGAAGCAGAGGCCCGAAACCTGAATAGTTTTGAAAGTTTGATTGACCACAACATC
TTATCAGCTCGTGAGTACCAGTCTGGCGACTATGAACGAAATGGCTACTATACCATCAAA
CTCTTTGCCCCAATCTATTCAGCTCTCAGCAGTGAGAAAGGCACACCAGGGGACCTTATG
GGACGTAGGATTGCGTACGAACTTTTGGCTGCCAAAGGCTTTAAGGATGGAATGGTACCT
TATATCTCAAACCAATACGAAGAAGATGCTAAACAACAAGGGCAAACTATCAATCTTTAT
GGTAAAGAACGGGGCTTGGTGACCGATGAGCTTGTTTTGAAAAAGGTATTTGACGGTAAG
TATAAAACTTGGGCAGAATTTAAGACAGCTATGTACCAAGAACGAGTGGATCAGTTTGGA
AACTTGAAGCAGGTGACCTTTAAAGATCCGACAAAACCATGGCCAAGCTATGGCACAAAG
ACTATCAATAATGTGGATGAATTGCAAGCCCTCATGGACCAAGCTGTTCTCAAGGATGCT
GAAGGTCCACGTTGGAGTAATTATGATCCAGAAATCGACAGTGCCGTTCATAAGTTGAAG
AGAGCAATCTTTAAAGCCTATCTTGACCAAACAAATGATTTTAGAAGTTCAATTTTTGAG
AATAAAAAATAG60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: INV104_09960 [new locus tag: INV104_RS05770 ]
- symbol: ZmpA
- description: IgA-protease
- length: 1963
- theoretical pI: 4.98821
- theoretical MW: 218616
- GRAVY: -0.685074
⊟Function[edit | edit source]
- reaction: EC 3.4.24.-? ExPASy
- TIGRFAM: gram-positive signal peptide, YSIRK family (TIGR01168; HMM-score: 44.4)and 1 moreCell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 21.6)
- TheSEED :
- IgA-specific metalloendopeptidase (EC 3.4.24.13)
- PFAM: no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 1149.3)and 6 morePeptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 273.7)G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 55.1)no clan defined Glug; The GLUG motif (PF07581; HMM-score: 47.8)YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 36)Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 29.7)PELOTA (CL0101) RbsD_FucU; RbsD / FucU transport protein family (PF05025; HMM-score: 7)
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb: Cellwall
- Cytoplasmic Score: 0
- Cytoplasmic Membrane Score: 0
- Cellwall Score: 10
- Extracellular Score: 0
- Internal Helices: 2
- DeepLocPro: Cell wall & surface
- Cytoplasmic Score: 0.0001
- Cytoplasmic Membrane Score: 0.0034
- Cell wall & surface Score: 0.8588
- Extracellular Score: 0.1376
- SignalP: Signal peptide SP(Sec/SPI) length 42 aa
- SP(Sec/SPI): 0.91723
- TAT(Tat/SPI): 0.067255
- LIPO(Sec/SPII): 0.005174
- Cleavage Site: CS pos: 42-43. VDA-QE. Pr: 0.9143
- predicted transmembrane helices (TMHMM): 3
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq: CBW36677 NCBI
- UniProt:
⊟Protein sequence[edit | edit source]
- MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGMGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIETKIDFQEEIQENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPSPRIVEKGTKKTQVIKEQPETGVEHKDVQSGSIVEPAIQPELPEAVVSDKGEPEVQPTLPEAVVTDKGETEVQPESPDTVVSDKGEPEQVAPLPEYKGNIEQVKPETPVEKTKEQGPEKTEEVPVKPTEETPVNPNEGTTEGTSIQEAENPVQPAEESTTNSEKVSPDTSSENTGEVSSNPSDSTTSVGESNKPEHNDSKNENSEKTVEEVPVNPNEGTVEGTSNQETEKPVQPAEETQTNSGKIANENTGEVSNKPSDSKPPVEESNQPEKNGTATKPENSGNTTSENGQTEPEKKLELRNVSDIELYSQTNGTYRQHVSLDGIPENTDTYFVKVKSSAFKDVYIPVASITEEKRNGQSVYKITAKAEKLQQELENKYVDNFTFYLDKKAKEENTNFTSFSNLVKAINQNPSGTYHLAASLNANEVELGPDERSYIKDTFTGRLIGEKDGKNYAIYNLKKPLFENLSGATVEKLSLKNVAISGKNDIGSLANEATNGTKIKQVHVDGVLAGERGVGGLLAKADQSSIAESSFKGRIVNTYETTDAYNIGGLVGHLTGKNASIAKSKATVTISSNTNRSDQTVGGLAGLVDQDAHIQNSYAEGDINNVKHFGKVAGVAGYLWDRTSGEEKHAGELTNVLSDVNVTNGNAITGYHYTGMKVANTFSSKANRVFNVTLEKDEVVSKESFEERGTMLDASQIVSKKAEINPLTLPTVEPLSTSGKKDSDFSKIAHYQANRALVYKNIEKLLPFYNKSTIVKYGNLVKENSLLYQKELLSAVMMKDDQVITDIVSNKQTANKLLLHYNDHSSEKFDLKYQTDFANLAEYNLGNTGLLYTPNQFLYDRDSIVKEVLPELQKLDYQSDAIRKTLGISPEVKLTELYLEDQFSKTKQNLGDSLKKLLSADAGLASDNSVTRGYLVDKIKNNKEALLLGLTYLERWYNFNYGQVNVKDLVMYHPDFFGKGNTSPLDTLIELGKSGFNNLLAKNNVDTYGISLASQHGTTDLFSTLEHYRKVFLPNTSNNDWFKSETKAYIVEEKSTIEEVKTKQGLAGTKYSIGVYDRITSATWKYRNMVLPLLTLPERSVFVISTMSSLGFGAYDRYRSSDHKAGKALNDFVEENARETAKRQRDHYDYWYRILDEQSREKLYRTILLYDAYKFGDDTTSGKATAEAKFDSSNPAMKNFFGPVGNKVVHNQHGAYATGDGVYYMSYRMLDKDGAITYTHEMTHDSDQDIYLGGYGRRNGLGPEFFAKGLLQAPDQPSDATITINSILKHSKSDSTEGSRLQVLDPTERFQNAADLQNYVHNMFDLIYMMEYLEGQSIVNKLSVYQKMAALRKIENKYVKDPADGNEVYATNVVKELTEAEARNLNSFESLIDHNILSAREYQSGDYERNGYYTIKLFAPIYSALSSEKGTPGDLMGRRIAYELLAAKGFKDGMVPYISNQYEEDAKQQGQTINLYGKERGLVTDELVLKKVFDGKYKTWAEFKTAMYQERVDQFGNLKQVTFKDPTKPWPSYGTKTINNVDELQALMDQAVLKDAEGPRWSNYDPEIDSAVHKLKRAIFKAYLDQTNDFRSSIFENKK
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- regulator:
⊟Transcription[edit | edit source]
- transcription start site:
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V:
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You can add further information about the gene and protein here. [edit]
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
Jeffrey N Weiser, Deborah Bae, Claudine Fasching, Ronald W Scamurra, Adam J Ratner, Edward N Janoff
Antibody-enhanced pneumococcal adherence requires IgA1 protease.
Proc Natl Acad Sci U S A: 2003, 100(7);4215-20
[PubMed:12642661] [WorldCat.org] [DOI] (P p)Damiana Chiavolini, Guido Memmi, Tiziana Maggi, Francesco Iannelli, Gianni Pozzi, Marco R Oggioni
The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.
BMC Microbiol: 2003, 3;14
[PubMed:12841855] [WorldCat.org] [DOI] (I e)E N Janoff, J B Rubins, C Fasching, D Charboneau, J T Rahkola, A G Plaut, J N Weiser
Pneumococcal IgA1 protease subverts specific protection by human IgA1.
Mucosal Immunol: 2014, 7(2);249-56
[PubMed:23820749] [WorldCat.org] [DOI] (I p)H Lomholt
Evidence of recombination and an antigenically diverse immunoglobulin A1 protease among strains of Streptococcus pneumoniae.
Infect Immun: 1995, 63(11);4238-43
[PubMed:7591053] [WorldCat.org] [DOI] (P p)K Poulsen, J Reinholdt, M Kilian
Characterization of the Streptococcus pneumoniae immunoglobulin A1 protease gene (iga) and its translation product.
Infect Immun: 1996, 64(10);3957-66
[PubMed:8926055] [WorldCat.org] [DOI] (P p)J H Wani, J V Gilbert, A G Plaut, J N Weiser
Identification, cloning, and sequencing of the immunoglobulin A1 protease gene of Streptococcus pneumoniae.
Infect Immun: 1996, 64(10);3967-74
[PubMed:8926056] [WorldCat.org] [DOI] (P p)