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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BM6001
serotype 19F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7465
serotype 1
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 19-NOV-2015

Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A66
  • locus tag: A66_00798 [new locus tag: A66_RS03975 ]
  • pan locus tag?: PNEUPAN001836000
  • symbol: A66_00798
  • pan gene symbol?:
  • synonym:
  • product: Histone acetyltransferase Gcn5

Genome View[edit | edit source]

Gene[edit | edit source]

General[edit | edit source]

  • type: CDS
  • locus tag: A66_00798 [new locus tag: A66_RS03975 ]
  • symbol: A66_00798
  • product: Histone acetyltransferase Gcn5
  • replicon: chromosome
  • strand: -
  • coordinates: 766665..767093
  • length: 429
  • essential: unknown

Accession numbers[edit | edit source]

  • Location: LN847353 (766665..767093) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0775 PneumoBrowse

Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    ATGTCTAACTATCGTAGAACTTCAAAACCGAAAACAGAACATATCAAAAAAGGCTTTACT
    GTTTTTCAAAAAACCATTACTACTATCGGTAGTATCCTTGGTTTGATTACCGCGGGTATC
    ACGATCATGAACGCCTTGGATAATAATAATAAAAATACTAAAAAAGAACCTACGACAAGC
    CAGACGACAACCTTTGTCAAAGAAATTCAAAAAGAATCCCCTCAGGAAAATACTACTCCA
    AATAAGGAAAATAACACTTCTCAAGAAAAAACACAACAAGAAGAAACGCCAAAATCTAGC
    GTCAAGGAAGAGAAAAAAGAAGATCAGAAAACAGCAACTCAGGACTCTACTACACCTGCT
    ACAAGTAAACCTGCCACTGAAAATGAAAAACAGCCCAATACTCCAACTTCAGAAAATAAT
    ACTCAATGA
    60
    120
    180
    240
    300
    360
    420
    429

Protein[edit | edit source]

General[edit | edit source]

  • locus tag: A66_00798 [new locus tag: A66_RS03975 ]
  • symbol: A66_00798
  • description: Histone acetyltransferase Gcn5
  • length: 142
  • theoretical pI: 9.79874
  • theoretical MW: 15847.3
  • GRAVY: -1.41761

Function[edit | edit source]

  • TIGRFAM:
    mobilome CxxCx(11)CxxC protein (TIGR04402; HMM-score: 12.9)
    integral membrane protein (TIGR04561; HMM-score: 11.9)
    and 5 more
    Genetic information processing Transcription Degradation of RNA ribonuclease Y (TIGR03319; EC 3.1.-.-; HMM-score: 10)
    Cellular processes Cellular processes Pathogenesis putative immunoglobulin-blocking virulence protein (TIGR04526; HMM-score: 7.6)
    Metabolism Energy metabolism TCA cycle dihydrolipoyllysine-residue succinyltransferase, E2 component of oxoglutarate dehydrogenase (succinyl-transferring) complex (TIGR01347; EC 2.3.1.61; HMM-score: 7.1)
    cobaltochelatase subunit (TIGR02442; EC 6.6.1.2; HMM-score: 6.7)
    pullulanase, extracellular (TIGR02102; HMM-score: 5.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined DUF6556; Family of unknown function (DUF6556) (PF20193; HMM-score: 97.7)
    and 21 more
    TrbC_VirB2 (CL0690) DUF4134; Domain of unknown function (DUF4134) (PF13572; HMM-score: 16.8)
    no clan defined DUF3807; Protein of unknown function (DUF3807) (PF12720; HMM-score: 13.2)
    DMT (CL0184) Zip; ZIP Zinc transporter (PF02535; HMM-score: 13)
    Multiheme_cytos (CL0317) C_GCAxxG_C_C; Putative redox-active protein (C_GCAxxG_C_C) (PF09719; HMM-score: 12.3)
    no clan defined DUF5427; Family of unknown function (DUF5427) (PF10310; HMM-score: 11.4)
    GPCR_A (CL0192) SID-1_RNA_chan; dsRNA-gated channel SID-1 (PF13965; HMM-score: 8.5)
    AhpD-like (CL0423) PA26; PA26 p53-induced protein (sestrin) (PF04636; HMM-score: 8.3)
    no clan defined RR_TM4-6; Ryanodine Receptor TM 4-6 (PF06459; HMM-score: 8.3)
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region (PF02932; HMM-score: 8.2)
    CIS_TMP; Contractile injection system tape measure protein (PF19268; HMM-score: 7.5)
    Serinc; Serine incorporator (Serinc) (PF03348; HMM-score: 7.2)
    vMSA; Major surface antigen from hepadnavirus (PF00695; HMM-score: 7.1)
    SLC12; Solute carrier family 12 (PF03522; HMM-score: 7.1)
    DDHD; DDHD domain (PF02862; HMM-score: 7)
    APC (CL0062) HCO3_cotransp; HCO3- transporter family (PF00955; HMM-score: 6.7)
    TPR (CL0020) Suf; Suppressor of forked protein (Suf) (PF05843; HMM-score: 6.7)
    no clan defined Snu56_snRNP; Snu56-like U1 small nuclear ribonucleoprotein component (PF19097; HMM-score: 6.1)
    Nucleocapsid (CL0156) Paramyxo_ncap; Paramyxovirus nucleocapsid protein (PF00973; HMM-score: 5.5)
    Peptidase_AD (CL0130) Presenilin; Presenilin (PF01080; HMM-score: 5.1)
    no clan defined DUF4551; Protein of unknown function (DUF4551) (PF15087; HMM-score: 5)
    Golgi_traff (CL0456) Hid1; High-temperature-induced dauer-formation protein (PF12722; HMM-score: 4.6)

Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

Localization[edit | edit source]

  • PSORTb: unknown (no significant prediction)
    • Cytoplasmic Score: 2.5
    • Cytoplasmic Membrane Score: 2.5
    • Cellwall Score: 2.5
    • Extracellular Score: 2.5
    • Internal Helix: 1
  • DeepLocPro: Cytoplasmic Membrane
    • Cytoplasmic Score: 0.0054
    • Cytoplasmic Membrane Score: 0.5204
    • Cell wall & surface Score: 0.2867
    • Extracellular Score: 0.1876
  • SignalP: no predicted signal peptide
    • SP(Sec/SPI): 0.405518
    • TAT(Tat/SPI): 0.014053
    • LIPO(Sec/SPII): 0.020374
  • predicted transmembrane helices (TMHMM): 1

Accession numbers[edit | edit source]

  • GI:
  • RefSeq: CRI61509 NCBI
  • UniProt:

Protein sequence[edit | edit source]

  • MSNYRRTSKPKTEHIKKGFTVFQKTITTIGSILGLITAGITIMNALDNNNKNTKKEPTTSQTTTFVKEIQKESPQENTTPNKENNTSQEKTQQEETPKSSVKEEKKEDQKTATQDSTTPATSKPATENEKQPNTPTSENNTQ

Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

Expression & Regulation[edit | edit source]

Operon[edit | edit source]

Regulation[edit | edit source]

  • regulator:

Transcription[edit | edit source]

  • transcription start site:

Expression data[edit | edit source]

Biological Material[edit | edit source]

Mutants[edit | edit source]

Expression vector[edit | edit source]

lacZ fusion[edit | edit source]

GFP fusion[edit | edit source]

two-hybrid system[edit | edit source]

FLAG-tag construct[edit | edit source]

Antibody[edit | edit source]

Other Information[edit | edit source]

You can add further information about the gene and protein here. [edit]

Literature[edit | edit source]

References[edit | edit source]

Relevant publications[edit | edit source]