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PangenomeTIGR4
serotype 4
D39serotype 2
D39Vserotype 2
Hungary19A-6serotype 19A
EF3030serotype 19F
670-6Bserotype 6B
6A-10serotype 6A
70585serotype 5
A026serotype 19F
A66serotype 3
AP200serotype 11A
ASP0581serotype 12F
ATCC 49619serotype 19F
ATCC 700669serotype 23F
BVJ1JLserotype 1
CGSP14serotype 14
G54serotype 19F
HU-OHserotype 3
Hu15serotype 19A
Hu17serotype 19A
INV104serotype 1
INV200serotype 14
JJAserotype 14
MDRSPN001serotype 19F
NCTC7466serotype 2
NU83127serotype 4
OXC141serotype 3
P1031serotype 1
R6serotype 2
SP49serotype 19A
SPN032672serotype 1
SPN034156serotype 3
SPN034183serotype 3
SPN994038serotype 3
SPN994039serotype 3
SPNA45serotype 3
ST556serotype 19F
TCH8431/19Aserotype 19A
Taiwan19F-14serotype 19F
Xen35serotype 4
gamPNI0373serotype 1
NCBI: 14-DEC-2023
⊟Summary[edit | edit source]
- organism: Streptococcus pneumoniae SPNA45
- locus tag: SPNA45_RS14170 [old locus tag: SPNA45_01464 ]
- pan locus tag?: PNEUPAN001587000
- symbol: SPNA45_RS14170
- pan gene symbol?: prtA
- synonym:
- product: S8 family serine peptidase
⊟Genome View[edit | edit source]
⊟Gene[edit | edit source]
⊟General[edit | edit source]
- type: CDS, pseudogene
- locus tag: SPNA45_RS14170 [old locus tag: SPNA45_01464 ]
- symbol: SPNA45_RS14170
- product: S8 family serine peptidase
- replicon: chromosome
- strand: -
- coordinates: 1480572..1487052
- length: 6481
- essential: unknown
⊟Accession numbers[edit | edit source]
- Location: NC_018594 (1480572..1487052) NCBI
- BioCyc:
- MicrobesOnline:
- PneumoBrowse for strain D39V: SPV_0558 PneumoBrowse
⊟Phenotype[edit | edit source]
Share your knowledge and add information here. [edit]
⊟DNA sequence[edit | edit source]
- 1
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601
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1021
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1381
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1501
1561
1621
1681
1741
1801
1861
1921
1981
2041
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2281
2341
2401
2461
2521
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3181
3241
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5641
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6481ATGAAAAAAAGTACAGTATTGTCATTAACCACAGCTGCAGTTATTTTAGCAGCCTATGCC
CCTAATGAGGTAGTCTTAGCAGACACATCTAGCTCTGAAGATGCTTTAAGCATATCTGAT
AAAGAAAAAGTAGTAGTAGATAAGGAAACAGAAAATAAAGAGAAACATGAAAATATCCAT
AGTGCTATGGAAACTTCACAGGATTTTAAAGAGAAGAAAACAGCAGTCATTGAGGAAAAA
GAAGTTGTTAGTAAAAATCCTGTGATAGACAATAACACTAGCAATGAAGAAGCAAAAATC
AAAGAAGAAAATTCCAATCAATCCCAAGGAGATCATACGGACTCATTTGTGAATAAAAAC
ACAGAAAATCCCAAAAAAGAAGATAGACTTGTCTATATTGCTGAATTTAAAGATAAAGAA
TCTGGAGAAAAAGCAATCAAGCAACTATACAGTCTTAAGAATACAAAAGTTTTATATACT
TATGATAGAATTTTTAACGGTAGTGCCATAGAAACAACTCCAGATAACTTGGACAAAATT
AAACAAATAGAAGGTATTTCATCGGTTGAAAGGGCACAAAAAGTCCAACCCATGATGAAT
CATGCCAGAAAGGAAATTGGAGTTGAGGAAGCTATTGATTACCTAAAGTCTATCAATGCT
CCGTTTGGGAAAAATTTTGATGGTAGAGGTATGGTCATTTCAAATATCGATACTGGAACA
GATTATAGACATAAGGCTATGAGAATCGATGATGATGCCAAAGCCTCAATGAGATTTAAA
AAAGAAGACTTAAAAGGCACTGATAAAAATTATTGGTTGAGTGATAAAATCCCTCATGCG
TTCAATTATTATAATGGTGGCAAAATCACTGTAGAAAAATATGATGATGGAAGGGATTAT
TTTGACCCACATGGGATGCATATTGCAGGGATTCTTGCTGGAAATGATACTGAACAAGAC
ATCAAAAACTTTAACGGCATAGATGGAATTGCACCTAATGCACAAATTTTCTCTTACAAA
ATGTATTCTGACGCAGGATCTGGGTTTGCGGGTGATGAAACAATGTTTCATGCTATTGAA
GATTCTATCAAACACAACGTTGATGTTGTTTCGGTATCATCTGGTTTTACAGGAACAGGT
CTTGTAGGTGAGAAATATTGGCAAGCTATTAGGGCATTAAGAAAAGCAGGCATTCCAATG
GTTGTCGCTACGGGTAACTATGCGACTTCTGCTTCAAGTTCTTCATGGGATTTAGTAGCA
AATAATCATCTGAAAATGACCGACACTGGAATGTAACACGAACTGCAGCACATGAAGATG
CGATAGCGGTCGCTTCTGCTAAAAATCAAACAGTTGAGTTTGATAAAGTTAACATAGGTG
GAGAAAGTTTTAAATACAGAAATATAGGGGCCTTTTTCGATAAGAATAAAATCACAACAA
ATGAAGATGGAACAAAAGCTCCTAGTAAATTAAAATTTGTATATATAGGCAAGGGGCAAG
ACCAAGATTTGATAGGTTTGGATCTTAGGGGTAAAATTGCAGTAATGGATAGAATTTATA
CAAAGGATTTAAAAAATGCTTTTAAAAAAGCTATGGATAAGGGTGCACGCGCCATTATGG
TTGTAAATACTGTAAATTACTACAATAGAGATAATTGGACAGAGCTTCCAGCTATGGGAT
ATGAAGCGGATGAAGGTACTAAAAGTCAAGTGTTTTCAATTTCAGGAGATGATGGTGTAA
AGCTATGGAACATGATTAATCCTAATAAAAAAACTGAAGTCAAAAGAAATGATAAAGAAG
ATTTTAAAGATAAATTGGAGCAATACTATCCAATTGATATGGAAAGTTTTAATTCCAACA
AACCGAATGTAGGTGACGAAAAAGAGATTGACTTTAAGTTTGCACCTGACACAGACAAAG
AACTCTATAAAGAAGATATCATCGTTCCAGCAGGATCTACATCTTGGGGGCCAAGAATAG
ATTTACTTTTAAAACCCGATGTTTCAGCACCTGGTAAAAATATTAAATCCACGCTTAATG
TTATTAATGGCAAATCAACTTATGGCTATATGTCAGGAACTAGTATGGCGACTCCAATCG
TGGCAGCTTCTACTGTTTTGATTAGACCGAAATTAAAGGAAATGCTTGAAAGACCTGTAT
TGAAAAATCTTAAGGGAGATGACAAAATAGACCTTACAAGTCTTACAAAAATTGCCCTAC
AAAATACTGCGCGACCTATGATGGATGCAACTTCTTGGAAAGAAAAAAGTCAATACTTTG
CATCACCTAGACAACAGGGAGCAGGCCTAATTAATGTGGCCAATGCTTTGAGAAATGAAG
TTGTAGCAACTTTCAAAAACACTGATTCTAAAGGTTTGGTAAACTCATATGGTTCCATTT
CTCTTAAAGAAATAAAAGGTGATAAAAAATACTTTACAATCAAGCTTCACAATACATCAA
ACAGACCTTTGACTTTTAAAGTTTCAGCATCAGCGATAACTACAGATTCTCTAACTGACA
GATTAAAACTTGATGAAACATATAAAGATGAAAAATCTCCAGATGGTAAGCAAATTGTTC
CAGAAATTCACCCAGAAAAAGTTAAAGGAGCAAATATCACATTTGAGCATGATACTTTCA
CTATAGGCGCAAATTCTAGCTTTGATTTGAATGCGGTTATAAATGTTGGAGAGGCCAAAA
ACAAAAATAAATTTGTAGAATCATTTATTCATTTTGAGTCAGTGGAAGAAATGGAAGCTC
TAAACTCCAACGGGAAGAAAATAAACTTCCAACCTTCTTTGTCGATGCCTCTAATGGGAT
TTGCTGGGAATTGGAACCACGAACCAATCCTTGATAAATGGGCTTGGGAAGAAGGGTCAA
GATCAAAAACACTGGGAGGTTATGATGATGATGGTAAACCGAAAATTCCAGGAACCTTAA
ATAAGGGAATTGGTGGAGAACATGGTATAGATAAATTTAATCCAGCAGGAGTTATACAAA
ATAGAAAAGATAAAAATACAACATCCCTGGATCAAAATCCAGAATTATTTGCTTTCAATA
ACCAAGGGATCAACGCTCCATCATCAAGTGGTTCTAAGATTGCTAACATTTATCCTTTAG
ATTCAAATGGAAATCCTCAAGATGCTCAACTTGAAAGAGGATTAACACCTTCTCCACTTG
TATTAAGAAGTGCAGAAGAAGGATTGATTTCAATAGTAAATACAAATAAAGAGGGAGAAA
ATCAAAGAGACTTAAAAGTCATTTCGAGAGAACACTTTATTAGAGGAATTTTAAATTCTA
AAAGCAATGATGCAAAGGGAATCAAATCATCTAAACTAAAAGTTTGGGGTGACTTGAAGT
GGGATGGACTTATCTATAATCCTAGAGGTAGAGAAGAAAATGCACCAGAAAGTAAGGATA
ATCCAGATCCTGCTACTAAGATAAGAGGTCAATTTGAACCGATTGCGGAAGGTCAATATT
TCTATAAATTTAAATATAGATTAACTAAAGATTACCCATGGCAGGTTTCCTATATTCCTG
TAAAAATTGATAACACCGCCCCTAAGATTGTTTCGGTTGATTTTTCAAATCCTGAAAAAA
TTAAGTTGATTACAAAGGATACTTATCATAAGGTAAAAGATCAGTATAAGAATGAAACGC
TATTTGCGAGAGATCAAAAAGAACATCCTGAAAAATTTGACGAGATTGCGAACGAAGTTT
GGTATGCTGGCGCCGCTCTTGTTAATGAAGATGGAGAGGTTGAAAAAAATCTTGAAGTAA
CTTACGCAGGTGAGGGTCAAGGAAGAAATAGAAAACTTGATAAAGACGGAAATACCATTT
ATGAAATTAAAGGTGCGGGAGATTTAAGGGGAAAAATCATTGAAGTCATTGCATTAGATG
GTTCTAGCAATTTCACAAAGATTCATAGAATTAAATTTGCTAATCAGGCTGATGAAAAGG
GGATGATTTCCTATTATCTAGTAGATCCTGATCAAGATTCATCTAAATATCAAAAGCTTG
GCGAGATTGCAGAATCTAAATTTAAAAATTTAGGAAATGGAAAAGAGGGTAGTCTAAAAA
AAGATACAACTGGGGTAGAACATCATCATCAAGAAAATGAAGAGTCTATTAAAGAAAAAT
CTAGTTTTACTATTGATAGAAATATTTCAACAATTAGAGACTTTGAAAATAAAGACCTAA
AGAAACTCATTAAAAAGAAATTTAGAGAAGTTGATGATTTTACAAGTGAAACTGGTAAGA
GAATAGAGGAATACGATTATAAATACGATGATAAGGGAAATATTATTGCTTATGACGATG
GTAGTGCCTTACAATATGAAACTGAAAAACTTGACGAAATAAAATCAAAAATTTATGGCG
TTCTAAGCCCATCTAAAGATGGACACTTTGAAATTCTTGGAAAGATAAGCAATGTTTCTA
AAAATGCCAAGGTATATTATGGAAATAGCTATAAATCGATAGAAATCAAAGCGACTAAGT
ATGACTCACATTCAAAAACGATGACATTTGATTTATACGCTAATATTAATGATATTGTGG
ATGGATTAGCTTTTGCTGGAGATATGCGGTTTTTTGTTAAAGATGATGATCGAATAAAAG
CTGAAACTAAAATTAGAATGCCTGAAAAAATAAGGAAACTAAAGCAGAATATCCCTATGT
ATCAAGTTATGGGAATGTAATCGAATTAGGAGAAGGAGATCTTTCAAAGAACAAACCAGA
CAATTTAACTAAAATGGAATCTGGTAAAATCTATTCTGATTCAGAAAAACAACAATATCT
GTTAAAGGATAACATCATTCTAAGAAAAGGCTATGCACTAAAAGTGACTACCTATAATCC
TGGAAAAACGGATATGTTAGAAGGAAATGGAGTCTATAGCAAGGAAGATATAGCAAAAAT
ACAAAAGGCCAATCCTAATCTAAGAGTCCTTTCAGAAACAACAATTTATGCTGATAGTAG
AAATGTTGAAGATGGAAGAAGTACCCAAGCTGTATTAATGTCGGCTTTGGACGGCTTTAA
CATTATAAGGTATCAAGTGTTTACATTTAAAATGAACGATAAAGGGGAAGCTATCGATAA
AGACGGAAATCTTGTGACAGATTCTTCTAAACTTGTATTATTTGGTAAGGATGATAAGGA
ATACACTGGAGAGGATAAGTCCAATGTAGAAGCTATAAAAGAAGATGGCTCCATGTTATT
TATTGATACCAAACCAGTAAACCTTTCAATGGATAAGAACTACTTTAATCCATCTAAATC
TAATAAAATTTATGTACGAAATCCAGAATTTTATTTAAGAGGTAAGATTTCTGATAAGGG
TGGTTTTAACTGGGAATTGAGAGTTAATGAATCGGTTGTAGATAATTATTTAATCTACGG
AGATTTACACATTGATAACACTAGAGATTTTAATATTAAGCTGAATGTTAAAGACGGTGA
CATCATGGACTGGGGAATGAAAGACTATAAAGCAAACGGATTTCCAGATAAGGTAACAGA
TATGGATGGAAATGTTTATCTTCAAACTGGCTATAGCGATTTGAATGCTAAAGCAGTTGG
AGTCCACTATCAGTTTTTATATGATAATGTTAAACCCGAAGTAAACGTTGATCCTAAGGG
AAATACTAGTATCGAATATGCTGATGGAAAATCTGTAGTCTTTAACATCAATGATAAAAG
AAATAATGGATTCGATGGTGAGATTCAAGAACAACATATTTATGTAAATGGAAAAGAATA
TACATCATTTGATGATATTAAACAAATAACAGACAAGACACTAAACATTAAGATTGTTGT
AAAAGATTTTGCAAGAAATACAACCGTAAAAGAATTCATTTTAAATAAAGATACGGGAGA
GGTAAGTGAATTAAAACCTCATAGGGTAACTGTGACCATTCAAAATGGAAAAGAAATGAG
TTCAACGATAGTGTCGGAAGAAGATTTTATTTTACCTGTTTATAAGGGTGAATTAGAAAA
AGGATACCAATTTGATGGTTGGGAAATTTCTGGTTTCGAAGGTAAAAAAGACGCTGGCTA
TGTTATTAATCTATCAAAAGATACCTTTATAAAACCTGTATTCAAGAAAATAGAGGAGAA
AAAGGAGGAAGAAAATAAACCTACTTTTGATGTATCGAAAAAGAAAGATAACCCACAAGT
AAACCATAGTCAATTAAATGAAAGTCATAGAAAAGAGGATTTACAAAGAGAAGATCATTC
ACAAAAATCTGATTCAACTAAGGATGTTACAGCTACAGTTCTTGATAAAAACAATATCAG
TAGTAAATCAACTACTAACAATCCTAATAAGTTGCCAAAAACTGGAACAGCAAGCGGAGC
CCAGACACTATTAGCTGCCGGAATAATGTTTATAGTAGGAATTTTTCTTGGATTGAAGAA
AAAAATCAAGATTAAGACAAAAGCTATAGAAAAAAATGGTTTATGTACTGAGATTAGATA
G60
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⊟Protein[edit | edit source]
⊟General[edit | edit source]
- locus tag: SPNA45_RS14170 [old locus tag: SPNA45_01464 ]
- symbol: SPNA45_RS14170
- description: S8 family serine peptidase
- length:
- theoretical pI:
- theoretical MW:
- GRAVY:
⊟Function[edit | edit source]
- TIGRFAM:
- TheSEED: data available for D39, Hungary19A-6, TIGR4
- PFAM:
⊟Structure, modifications & cofactors[edit | edit source]
- domains:
- modifications:
- cofactors:
- effectors:
⊟Localization[edit | edit source]
- PSORTb:
- SignalP:
- predicted transmembrane helices (TMHMM):
⊟Accession numbers[edit | edit source]
- GI:
- RefSeq:
- UniProt:
⊟Protein sequence[edit | edit source]
⊟Experimental data[edit | edit source]
- protein localization:
- interaction partners:
⊟Expression & Regulation[edit | edit source]
⊟Operon[edit | edit source]
⊟Regulation[edit | edit source]
- data available for TIGR4
⊟Expression data[edit | edit source]
- PneumoExpress for strain D39V: SPV_0558 PneumoExpress
⊟Biological Material[edit | edit source]
⊟Mutants[edit | edit source]
⊟Expression vector[edit | edit source]
⊟lacZ fusion[edit | edit source]
⊟GFP fusion[edit | edit source]
⊟two-hybrid system[edit | edit source]
⊟FLAG-tag construct[edit | edit source]
⊟Antibody[edit | edit source]
⊟Other Information[edit | edit source]
You are kindly invited to share additional interesting facts.
⊟Literature[edit | edit source]
⊟References[edit | edit source]
⊟Relevant publications[edit | edit source]
G Bethe, R Nau, A Wellmer, R Hakenbeck, R R Reinert, H P Heinz, G Zysk
The cell wall-associated serine protease PrtA: a highly conserved virulence factor of Streptococcus pneumoniae.
FEMS Microbiol Lett: 2001, 205(1);99-104
[PubMed:11728722] [WorldCat.org] [DOI] (P p)Shaper Mirza, Landon Wilson, William H Benjamin, Jan Novak, Stephen Barnes, Susan K Hollingshead, David E Briles
Serine protease PrtA from Streptococcus pneumoniae plays a role in the killing of S. pneumoniae by apolactoferrin.
Infect Immun: 2011, 79(6);2440-50
[PubMed:21422179] [WorldCat.org] [DOI] (I p)Sacha F de Stoppelaar, Hester J Bootsma, Aldert Zomer, Joris J T H Roelofs, Peter W M Hermans, Cornelis van 't Veer, Tom van der Poll
Streptococcus pneumoniae serine protease HtrA, but not SFP or PrtA, is a major virulence factor in pneumonia.
PLoS One: 2013, 8(11);e80062
[PubMed:24244609] [WorldCat.org] [DOI] (I e)