PangenomeTIGR4

serotype 4

D39

serotype 2

D39V

serotype 2

Hungary19A-6

serotype 19A

EF3030

serotype 19F

670-6B

serotype 6B

6A-10

serotype 6A

70585

serotype 5

A026

serotype 19F

A66

serotype 3

AP200

serotype 11A

ASP0581

serotype 12F

ATCC 49619

serotype 19F

ATCC 700669

serotype 23F

BM6001

serotype 19F

BVJ1JL

serotype 1

CGSP14

serotype 14

G54

serotype 19F

HU-OH

serotype 3

Hu15

serotype 19A

Hu17

serotype 19A

INV104

serotype 1

INV200

serotype 14

JJA

serotype 14

MDRSPN001

serotype 19F

NCTC7465

serotype 1

NCTC7466

serotype 2

NU83127

serotype 4

OXC141

serotype 3

P1031

serotype 1

R6

serotype 2

SP49

serotype 19A

SPN032672

serotype 1

SPN034156

serotype 3

SPN034183

serotype 3

SPN994038

serotype 3

SPN994039

serotype 3

SPNA45

serotype 3

ST556

serotype 19F

TCH8431/19A

serotype 19A

Taiwan19F-14

serotype 19F

Xen35

serotype 4

gamPNI0373

serotype 1

⊟Summary

• pan ID^?: PNEUPAN001572000
• symbol^?: zmpB
• synonym:
• description^?: ZmpA/ZmpB/ZmpC family metallo-endopeptidase

  descriptions from strain specific annotations:

  • ZmpA/ZmpB/ZmpC family metallo-endopeptidase
  • zinc metalloprotease ZmpB
  • putative zinc metalloproteinase ZmpB
  • Zinc metalloprotease
  • Zinc metalloprotease ZmpB precursor
  • G5 domain-containing protein
  • Immunoglobulin A1 protease
  • LPXTG cell wall anchor domain protein
  • LPXTG-motif cell wall anchor domain protein
  • peptidase M26
  • Zinc metalloprotease B
  • Zinc metalloprotease B (pseudogene)
  • pseudogene
• strand^?: +
• coordinates^?: 1996001..2014989
• occurrence^?: in 65% of 43 strains

⊟Orthologs

TIGR4:
—
D39:
SPD_RS03120 (zmpB)
D39V:
SPV_RS03115 (zmpB)
Hungary19A-6:
SPH_RS03685
EF3030:
—
670-6B:
—
6A-10:
HKM25_RS03160
70585:
SP70585_RS03550
A026:
T308_RS03165
A66:
A66_RS03015
AP200:
SPAP_RS03230
ASP0581:
EL334_RS03330
ATCC 49619:
—
ATCC 700669:
—
BM6001:
ODS73_RS03555
BVJ1JL:
—
CGSP14:
—
G54:
SPG_RS03070
gamPNI0373:
—
HU-OH:
EL271_RS03075
Hu15:
SPNHU15_RS03345
Hu17:
SPNHU17_RS03285
INV104:
INV104_RS03260
INV200:
—
JJA:
—
MDRSPN001:
—
NCTC7465:
—
NCTC7466:
DQM66_RS03120 (zmpB)
NU83127:
—
OXC141:
SPNOXC_RS03260
P1031:
—
R6:
SPR_RS02945 (zmpB)
SP49:
BMJ42_RS03850
SPN032672:
SPN032672_RS09520
SPN034156:
SPN034156_RS09185
SPN034183:
SPN034183_RS03275
SPN994038:
SPN994038_RS03195
SPN994039:
SPN994039_RS03195
SPNA45:
SPNA45_RS05645
ST556:
MYY_RS03645
Taiwan19F-14:
SPT_RS03425
TCH8431/19A:
HMPREF0837_RS04595
Xen35:
—

⊟Genome Viewer

D39
D39V
Hungary19A-6

⊟Alignments

• alignment of orthologues:
  CLUSTAL format alignment by MAFFT L-INS-i (v7.505)
  
  
  D39             MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRN
  D39V            MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRN
  Hungary19A-6    MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRN
                  ************************************************************
  
  D39             EVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGTMGLVVLPSA
  D39V            EVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGTMGLVVLPSA
  Hungary19A-6    EVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSA
                  **************************************************:*********
  
  D39             GAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVET
  D39V            GAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVET
  Hungary19A-6    GAVDPVATLALASREGVVEMDGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVET
                  ********************:***************************************
  
  D39             PQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSA
  D39V            PQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSA
  Hungary19A-6    PQSTTNQEQARTENQVVETEEAPKEEAPRTEESPKEEPKSEVKPTDDTLPKVEEGKEDSA
                  ****************************:*******************************
  
  D39             EPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEQAGE-------PVAPRKDEQA
  D39V            EPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEQAGE-------PVAPRKDEQA
  Hungary19A-6    EPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEPPVEQAKVPEQPVQPTQAEQP
                  *************************************** . *       ** * : **.
  
  D39             PVEPE-NQPEAPEEEKAVEETPKQEE----STPDTKAEETVEPKEETKTAKGTQEEGKEG
  D39V            PVEPE-NQPEAPEEEKAVEETPKQEE----STPDTKAEETVEPKEETKTAKGTQEEGKEG
  Hungary19A-6    STPKESSQQENPKEDRGAEETPKQEDEQPAEAPEIKVEEPVESKEETKTAKGTQEEGKEG
                  ..  * .* * *:*::..*******:    .:*: *.**.**.*****************
  
  D39             QAPVQEVNPEYKVTTGTVEKSTESELDFTTEVVPDDTKYVDEEVVERQGSKGVQVTKTTY
  D39V            QAPVQEVNPEYKVTTGTVEKSTESELDFTTEVVPDDTKYVDEEVVERQGSKGVQVTKTTY
  Hungary19A-6    QAPVQEVNPEYKVTTGTVEKSTESELDFTTEVVPDDTKYVDEEVVERQGSKGVQVTKTTY
                  ************************************************************
  
  D39             ETVEVVETDKVLSTTTEVKTPVVPKVVKKGTKP-----VETREEVIPFATKEQEDDTLKR
  D39V            ETVEVVETDKVLSTTTEVKTPVVPKVVKKGTKP-----VETREEVIPFATKEQEDDTLKR
  Hungary19A-6    ETVEVVETDKVLSTTTEVKTPVVPKVVKKGTKPVEGTAVETREEVIPFATKEQEDGTLKR
                  *********************************     *****************.****
  
  D39             GTRQVAQEGVNGKKQITETYKTIRGEKTNEAPTVEETVLQAPQDEIIKKGTKGLEKPTLQ
  D39V            GTRQVAQEGVNGKKQITETYKTIRGEKTNEAPTVEETVLQAPQDEIIKKGTKGLEKPTLQ
  Hungary19A-6    GTRQVAQEGVNGKKQITETYKTIRGEKTNEAPTVEETVLQAPQDEIIKKGTKGLEKPTLE
                  ***********************************************************:
  
  D39             WANTEKDVLKKSATASYTLTKPAGVEIKSIKLALKDKDGQLVKEVTVAENNLNATLDKLK
  D39V            WANTEKDVLKKSATASYTLTKPAGVEIKSIKLALKDKDGQLVKEVTVAENNLNATLDKLK
  Hungary19A-6    WVKTDKDVLKKSATASYTLNKPDGVEIKSIKVALKDNTGTVIKEVTVEENNLNVTLDNLK
                  *.:*:**************.** ********:****: * ::***** *****.***:**
  
  D39             YYQGYTLSTTMVYDRGEGEETEKLEDKQIQLDLKKVEIKNIKETSLMNVDAEGNETDKSL
  D39V            YYQGYTLSTTMVYDRGEGEETEKLEDKQIQLDLKKVEIKNIKETSLMNVDAEGNETDKSL
  Hungary19A-6    YYQGYTLSTTMVYNRGEGEETETLEDKEVQLDLKKVEIKNIKETSLMSVDDAGVETDKSL
                  *************:********.****::******************.**  * ******
  
  D39             LSEKPTDVSQLYLRVTTHDNKVTRLAVSSVEEVVVDGKTLYKVVAKAPDLVQRRADDTLS
  D39V            LSEKPTDVSQLYLRVTTHDNKVTRLAVSSVEEVVVDGKTLYKVVAKAPDLVQRRADDTLS
  Hungary19A-6    LTEKPTDVAPLYLRVTTHDNKVTRLAVDKIEEVEEDGKTLYKVTAKAPDLVQRNADNTLS
                  *:******: *****************..:***  ********.*********.**:***
  
  D39             EEYVHYFEKQLPKVNNVYYNFNELVKDMQANPMGEFKLGADLNAVNVKPAGKAYVMAKFR
  D39V            EEYVHYFEKQLPKVNNVYYNFNELVKDMQANPMGEFKLGADLNAVNVKPAGKAYVMAKFR
  Hungary19A-6    EEYVHYFEKQLPKIGNVYYNFNELITDMQKTPNGEFKLGADLNAVNVPTPNKSYVTAKFT
                  *************:.*********:.*** .* ************** ...*:** *** 
  
  D39             GTLSSVENHQYTIHNLERPLFNEAEGATLKNFNLGNVNINMPWADKVAPIGNMFKKSTLE
  D39V            GTLSSVENHQYTIHNLERPLFNEAEGATLKNFNLGNVNINMPWADKVAPIGNMFKKSTLE
  Hungary19A-6    GKLYSEGDKHYTIHNLARPLFAQAENAHIHDINLGNVNINMPWANKTAPLGEMFKKSTIE
                  *.* *  :::****** **** :**.* ::::************:*.**:*:******:*
  
  D39             NIKVVGSVTGNNDVTGAVNKLDEANMRNVAFIGKINSLGDKGWWSGGLVSESWRSNTDSV
  D39V            NIKVVGSVTGNNDVTGAVNKLDEANMRNVAFIGKINSLGDKGWWSGGLVSESWRSNTDSV
  Hungary19A-6    NVKVTGNVVGNNDVTGMVNKLDESDMRNVAFIGNITSVGSAGWWSGGLVSESWRSNTDNS
                  *:**.*.*.******* ******::********:*.*:*. *****************. 
  
  D39             YFDGDIVGNNSKFGGLVAKVNHGSNQWDVKQKGRLTNSVVKGTMTLKNHGQSGGLVHENY
  D39V            YFDGDIVGNNSKFGGLVAKVNHGSNQWDVKQKGRLTNSVVKGTMTLKNHGQSGGLVHENY
  Hungary19A-6    YIDTTIKGNKAKVGGLIAKLNHGADPRDVGARGRLKNSVAKGTIDVRDPQETGGLLHSNW
                  *:*  * **::*.***:**:***::  **  :***.***.***: :::  ::***:*.*:
  
  D39             DWGWVENNISMMKVNN-GEIMYGSGSIDGDPYFGFDYFK-NNYYVKDVATGESTYKRSKQ
  D39V            DWGWVENNISMMKVNN-GEIMYGSGSIDGDPYFGFDYFK-NNYYVKDVATGESTYKRSKQ
  Hungary19A-6    SWGLAENNITMMKVKNGGEILYGSRDAEDDDYFGANWVRNNNAFVNGISEGKQSYSRSSR
                  .** .****:****:* ***:*** . :.* *** ::.: ** :*:.:: *:.:*.**.:
  
  D39             IQSISQAEADAKIANMGITANTFAIQDPVVNKLNRIIDRDSEYKAIQDYQETRNLAYRNL
  D39V            IQSISQAEADAKIANMGITANTFAIQDPVVNKLNRIIDRDSEYKAIQDYQETRNLAYRNL
  Hungary19A-6    WKGISEDEAKTRIAKMGITAHEYEITQHLTDKLNRAAFKEDTYKTTQDYKTERELAYRNI
                   :.**: **.::**:*****: : * : :.:****   ::. **: ***:  *:*****:
  
  D39             EKLQPFYNKEWIVNQGNKLTDESNLVKKTVLSVTGMKSGQFVTDLSSVDKIMIHYADGTK
  D39V            EKLQPFYNKEWIVNQGNKLTDESNLVKKTVLSVTGMKSGQFVTDLSSVDKIMIHYADGTK
  Hungary19A-6    EKLQPFYNKEWIINQGNKLTDGSNLMIKEVLSVIGMKNGQFVTDLSDIDKIMIHYADGTK
                  ************:******** ***: * **** ***.********.:************
  
  D39             EEFGVSAISDSRVKQVKEYNVDDLG-VVYTPNMVDKNRDSLITKVKEKLSSVALDSAEVK
  D39V            EEFGVSAISDSRVKQVKEYNVDDLG-VVYTPNMVDKNRDSLITKVKEKLSSVALDSAEVK
  Hungary19A-6    EEKTVTRKADSKVQQIREYSVEGLGDVVYTPNMVEKDRAQLITDIKAKLDSVQLISPEVR
                  **  *:  :**:*:*::**.*:.** ********:*:* .***.:* **.** * *.**:
  
  D39             SITNNPA---------------SLYLEESFAEVRETLDKLVKSLLENEDHQLNSDEVAEK
  D39V            SITNNPA---------------SLYLEESFAEVRETLDKLVKSLLENEDHQLNSDEVAEK
  Hungary19A-6    NLMDKRGKAHENTDERRNGYIRNLFLEESLDEVKGNLDKLVKALVENEDHQLNGDEAAMK
                  .: :: .               .*:****: **: .******:*:********.**.* *
  
  D39             ALLKKVEDNKAKIILALTYLNRYYGIDYDGLNFKHLMMFKPDFYGKTPSILDFLIRIGSA
  D39V            ALLKKVEDNKAKIILALTYLNRYYGIDYDGLNFKHLMMFKPDFYGKTPSILDFLIRIGSA
  Hungary19A-6    ALVKKVEDNKAKIMLGLAYLNRYYGFKYDEKSMKDIMMFKPDFYGKNVSVLDFLIRVGSR
                  **:**********:*.*:*******:.**  .:*.:**********. *:******:** 
  
  D39             EKNLKGDRSLEAYREVIGGTIGKGELNGLLGYNMRLFTKYTDLNDWFIHAAKNV-YVSEP
  D39V            EKNLKGDRSLEAYREVIGGTIGKGELNGLLGYNMRLFTKYTDLNDWFIHAAKNV-YVSEP
  Hungary19A-6    EHNIKGNRTLEAYREVIGGTIGIGELNGFLNYNMRLFTEETDINTWYKKAVSHTNYIVEK
                  *:*:**:*:************* *****:*.*******: **:* *: :*..:. *: * 
  
  D39             ETTTEDFKDKRHRIYDGLNNDVHGRMILPLLNLKKAHIFVISTYNTIAFSSFEKYGKNTE
  D39V            ETTTEDFKDKRHRIYDGLNNDVHGRMILPLLNLKKAHIFVISTYNTIAFSSFEKYGKNTE
  Hungary19A-6    QSSNPAFANKKYRLYENLNNGEHGKYILPLLTTKKAHMFLISTYNTLAFSAFEKYGKNTE
                  :::.  * :*::*:*:.***. **: *****. ****:*:******:***:*********
  
  D39             EERNAYKAEIDRVAKAQQRYLDFWSRLALPKVRNQLLKSQNSVPTPVWDNQVYVGLGGAN
  D39V            EERNAYKAEIDRVAKAQQRYLDFWSRLALPKVRNQLLKSQNSVPTPVWDNQVYVGLGGAN
  Hungary19A-6    AEREAFKKEIDLRAQEQINYLDFWSRLAADNVRDRLLKSENMVPSAIWDNQEVPGHGWAD
                   **:*:* ***  *: * .*********  :**::****:* **:.:****   * * *:
  
  D39             RMGYGDGGRVVTPVRELFGPTDRWHQINWNMGAMAKIYERPWKDDQVYFMVTNMMEPFGI
  D39V            RMGYGDGGRVVTPVRELFGPTDRWHQINWNMGAMAKIYERPWKDDQVYFMVTNMMEPFGI
  Hungary19A-6    RMGHNKNGD-YAPVREFYGPTGKWHGYN-GTGAYAYIFTNPQNSEAVYYIISSMISDFGT
                  ***:...*   :****::***.:**  * . ** * *: .* :.: **::::.*:. ** 
  
  D39             SAFTHETTHVNDRMAYYGGDWHREGTDLEAFAQGMLQTPDKSTTNGEYGALGINMAYERK
  D39V            SAFTHETTHVNDRMAYYGGDWHREGTDLEAFAQGMLQTPDKSTTNGEYGALGINMAYERK
  Hungary19A-6    SAFTHETTHINDRMAYLGGWRHREGTDVEAFAQGMLQSPAVSSPNGDYGALGLNMAYKRE
                  *********:****** **  ******:*********:*  *:.**:*****:****:*:
  
  D39             NDGEQLYNYDPEKLDSREKIDSYMKNYNESMMMLDYLEASAVIRQNLSDNSKWFKKMDKE
  D39V            NDGEQLYNYDPEKLDSREKIDSYMKNYNESMMMLDYLEASAVIRQNLSDNSKWFKKMDKE
  Hungary19A-6    NDGNQWYNYDSNKLDSRAKIDHYMKNYNEALMMLDHLEADAVIAKNNGDNNKWFKKMDKK
                  ***:* ****.:***** *** *******::****:***.*** :* .**.********:
  
  D39             WRTNADRNRLIGEPHQWDKLRDLTEEEKKLPIDSIDKLVENNFVTLHGMPKNGRYRTEGF
  D39V            WRTNADRNRLIGEPHQWDKLRDLTEEEKKLPIDSIDKLVENNFVTLHGMPKNGRYRTEGF
  Hungary19A-6    WRENANRNGLVGQPHQWDLLRDLNEEENKKKLTSIDDLVDGNYVTKHNMPGNKHYRAEGF
                  ** **:** *:*:***** ****.***:*  : ***.**:.*:** *.** * :**:***
  
  D39             DSSYQPVNMMAGVFGGNTSKSTVGSISFKHNAFRMWGYYGYENGFIPYVSNKLKGAANKE
  D39V            DSSYQPVNMMAGVFGGNTSKSTVGSISFKHNAFRMWGYYGYENGFIPYVSNKLKGAANKE
  Hungary19A-6    DTAYQTVNMMAGIYGGNTSKSAVGSISFKHNTFRMWGYFGYLDGFVGYASNKYKDAANKE
                  *::**.******::*******:*********:******:** :**: *.*** *.*****
  
  D39             NKGLLGDDFIIKKVSKNQFQNLEEWKKHWYHEVYDKAQKGFVEIEVDGVKISTYAQLQSL
  D39V            NKGLLGDDFIIKKVSKNQFQNLEEWKKHWYHEVYDKAQKGFVEIEVDGVKISTYAQLQSL
  Hungary19A-6    NKGLLGDDFIIKKVSDGKFDSLEAWKKEWFKEVKAKGEKGFVAIEIDGKTITNYAELREL
                  ***************..:*:.** ***.*::**  *.:**** **:** .*:.**:*:.*
  
  D39             FEEAVSKDLAGMDDKNIKNHYQYTENLKWKIYKQLLKNTDGFSSDLFTAPQA
  D39V            FEEAVSKDLAGMDDKNIKNHYQYTENLKWKIYKQLLKNTDGFSSDLFTAPQA
  Hungary19A-6    FDKAVEADLKAGNSNQ-------TVALKEKVYKQLLQKSDGFVGNLFKA---
                  *::**. ** . :.::       *  ** *:*****:::*** .:**.*