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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 17-JAN-2021

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae A026
  • locus tag: T308_RS03165 [old locus tag: T308_03135 ]
  • pan locus tag?: PNEUPAN001606000
  • symbol: T308_RS03165
  • pan gene symbol?: zmpB
  • synonym:
  • product: G5 domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: T308_RS03165 [old locus tag: T308_03135 ]
  • symbol: T308_RS03165
  • product: G5 domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 613204..618912
  • length: 5709
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_022655 (613204..618912) NCBI
  • BioCyc: T308_RS03165 BioCyc
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0577 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    3961
    4021
    4081
    4141
    4201
    4261
    4321
    4381
    4441
    4501
    4561
    4621
    4681
    4741
    4801
    4861
    4921
    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    5461
    5521
    5581
    5641
    5701
    GTGTTTAAAAAAGACCGTTTTTCAATTCGTAAGATTAAGGGAGTTGTAGGCTCTGTATTT
    CTTGGAAGCCTTTTGATGGCTCCTTCTGTAGTGGACGCAGCCACCTATCACTATGTAAAT
    AAAGAGATTATTTCACAAGAAGCTAAAGATTTAATTCAGACAGGAAAGCCTGACAGGAAT
    GAAGTTGTATATGGTTTGGTGTATCAAAAAGATCAGTTGCCTCAAACAGGGACAGAAGCA
    TCTGTTTTGACAGCTTTTGGTTTGCTGACTGTTGGGAGCTTGCTTTTAATCTACAAGAGA
    AAGAAAATTGCTAGCGTCTTTCTAGTTGGAGCTATGGGATTGGTAGTTCTTCCTAGTGCA
    GGGGCTGTAGACCCAGTTGCGACCCTAGCACTGGCTAGTCGAGAGGGTGTTGTTGAAATG
    GAGGGCTATCGCTATGTTGGTTATCTATCAGGTGACATCCTCAAAACGCTTGGCTTGGAC
    ACTGTTTTAGAAGAAACCTCAGCAAAACCTGGAGAGGTGACTGTAGTCGAAGTTGAGACT
    CCTCAATCAACAACAAATCAGGAGCAAGCTAGGACAGAAAACCAAGTAGTAGAGGCAGAG
    GAAGCTCCAAAAGAAGAAGCACCTAAAACAGAAGAAAGTCCAAAGGAAGAACCAAAATCG
    GAGGTAAAACCTACTGACGACACCCTTCCTAAAGTAGAAGAGGGGAAAGAAGATTCAGCA
    GAACCAGCTCCAGTTGAAGAAGTAGGTGGAGAAGTTGAGTCAAAACCAGAGGAAAAAGTA
    GCAGTTAAGCCAGAAAGTCAACCATCAGACAAACCAGCTGAGGAATCAAAAGTTGAACCA
    CCAGTAGAACAAGCAAAAGGCCCAGAACAACCCGTGCAACCTACACAAGCTGAGCAACCA
    AGGATACCAAAAGATTCATCACAACCAGAAGATCCTAAAGAAGATAGGGGAGCGGAAGAG
    ACACCGAAACAAGAAGATGAACAGCCAGCAGAAGCCCCAGAAATCAAGGTTGAAGAACCA
    GTAGAATCAAAAGAGGAGACTAAAACAGCTAAGGGGACGCAAGAAGAAGGCAAAGAAGGT
    CAAGCACCAGTACAAGAAGTAAACCCAGAATATAAAGTAACAACAGGTACAGTTGAGAAG
    TCTACCGAAAGTGAATTAGATTTCACAACAGAAGTAGTTCCGGATGACACAAAATATGTA
    GATGAAGAAGTTGTTGAACGTCAAGGGTCTAAAGGAGTTCAAGTTACGAAAACAACTTAC
    GAAACAGTGGAAGTTGTAGAGACAGACAAAGTCCTTTCTACAACTACAGAAGTGAAAACT
    CCTGCTGTTCCTAAAGTCGTTAAAAAAGGAACAAAACCAGTTAAAGGAACAGCAGTCGAA
    ACAAGAGAAGAAGTCATTCCTTTTGCTACGAAAGAACAAGAAGATGACACTTTAAAACGC
    GGAACAAGACAAGTAGCTCAAGAAGGTGTAAATGGTAAGAAACAAATTACTGAAACCTAT
    AAAACAATTCGCGGAGAAAAAACAAACGAAGCTCCAACAGTAGAAGAAACAGTTCTCCAA
    GCACCTCAAGATGAGATTATCAAAAAAGGCACAAAAGGTTTAGAAAAACCAACCTTAGAA
    TGGGTTAAAACAGATAAAGATGTCTTGAAGAAGAGTGCGACAGCCAGTTATACATTGAAT
    AAACCAGATGGGGTAGAAATCAAATCCATCAAAGTAGCTCTAAAAGATAATACTGGAACA
    GTTATTAAAGAAGTAACGGTAGAAGAAAATAACTTAAACGCTACTTTAGACAACTTGAAA
    TATTATCAAGGTTATACACTATCCACAACCATGGTCTATAATCGAGGCGAAGGCGAAGAA
    ACTGAAACGTTAGAAGATAAAGAAGTTCAGTTAGACCTTAAAAAAGTTGAAATCAAAAAC
    ATCAAAGAAACTAGCTTGATGAGTGTGGATGATGCTGGTGTTGAAACAGATAAGAGCTTA
    CTTACTGAAAAACCGACAGACGTTGCTCCACTTTACCTACGAGTGACAACTCATGATAAC
    AAAACAACAAGACTGGCAGTAAGTTCAGTTGAAGAAGTTGTTGTTGATGGAAAAACATTG
    TACAAAGTGGTAGCTAAAGCTCCTGACTTAGTTCAACGTAGAGAAGATGATACACTAAGC
    GAAGAGTATGTACATTACTTTGAAAAACAATTACCAAAAGTAGATAATGTGTACTATAGC
    TTTAACGAGTTAATTACAGATATGCAAAAAAATCCTACTGGTACATTCAAACTAGGTGCA
    GATCTTAATGCAGCGAATACTCCAACTCCAAGTAAATCATATGTAACAGGTGAATTTAAA
    GGTAAATTATCAAGTGTTGATGGTCAACATTATACGATTCACAATACTGCGCGCCCATTA
    TTTAACAATATTGTTGGTGGTACCGTTAAAAATATTAATCTTAACAATGTAAATATCGAT
    ATGCCTTGGGCTGATCAAATTGCATCTGTAGCAAATGTGATCAAAGGTGGTAGCCTTATT
    GAGAATGTTAAAGTCAAAGGTAATGTGCTCGGCAGAAACTGGGTATCTGGTTTCATTGAT
    AAAATTGACAGTGGTGGTAGATTAGTTAATGTTGCATTTATTGGTAATGTAACTTCTGTT
    GGAGATGGGGATAAATTCTTAACAGGTATTGTTGGAGAAAACTGGAAAGGATATGTCGAA
    AAAGCATACGTTGAAGCTAATATTAAAGGTAAGCGAGCTAAAGCTGCTGGTATATCTTAT
    TGGTCGCAAAATAGCGGAGATAATAATGCTGTCGGTAGAGATGGAGCAATTAAGAAATCT
    GTCGTTAAAGGTTCAATAGATGTAGAAAAACCAATTGAAGTTGGTGGCGCTGTTGGAAGT
    TTAAATTATCTTGGTTATATAGAAGACACTGTTGCTATGATGAAAGTTAAGAACGGTGAA
    ATTTTCTACGGTTCGCATGATATCGATACCGATCCATATTACACAGGAGAACGAGTAAAT
    AGAAATTTCATTGTTGACGGTGTAAGTGAAGGTAAATCTTCGTATACATACTCTAAACAA
    CAAAAGCGTATTAAATCAATATCTCAAGAGGAAGCAGATAAGAAAATTAAAGAATTGGGT
    ATCACAGCAGATAAATTTACAATTATCGATCCAATTGTAAATAAACTTAACAACATCAAA
    CAAAAAGCTGATACTTATAAAGATACTCAAGATTACAAAGCAGACCGTGAACTTACTTAT
    CGTAATATCGAAAAACTTCAACCATTCTACAATAAAGAGTGGATTGTAGACCAAGGTAAT
    AAAGTTCCATCAAATTCTAAATTATTAACTACAGAAGTATTATCTGTTACAGGTATAAAG
    AGCGGTCAATTCGTAACTGATTTGTCAGATATTGATAAAATTATGATTCACTATTCTGAT
    GGAGCAAAGGAAGAATTGAATGTTACTCGTCAAGAATCAAACGTTCAACAAGTGCGTGAG
    TACAGTATCACAGATTTAGATATACTCTATACACCAAATATGGTTGAGAAAGATCGCGCT
    CAGTTGATGACTGATGTAAAGTCTAAGCTATCTAGTGTAGAATTAGAGTCTGATGGAGTG
    CGTCAACTTCTCGTTAAGAGAGATACTAAGAAAGATGCGAATGCAAATAGTGTAGGTCGT
    CAAAATGGATACATTAGAGATTTATTCCTTGAAGAAAGTTTCTCTGAAGTTAAAGCAAAT
    CTTGACAAATTGGTAAAACAGATACTTGAAAATGAAGATCATCAACTCAACGATAACGAA
    TTAGCTGAACGTGCTTTACTGAAGAAAGTTGAAGATAATAAAGCTAAAATCATGATGGGA
    CTGGCATACTTAAATCAATATTATGCTTTTAAATACGATGAGTTATCAATTAAAGATATT
    ATGATGTTTAAACCTGATTTTTATGGTAAGACAGCAAGTGTTATTGATAGATTGATTAAT
    ATTGGTTCTGCAGAAAATAATCTAAAAGGAGATAGAACGCAAGATGCTTATCGTGGTATA
    ATTTCAGGGGCAACAGGTAAAGGTAGTTTACATGACTTCTTGACCTACAATATGAAATTA
    TTCACAAATGAAACAGACATAAATGTTTGGTTTAAGAAAGCTATTGAAAAGAATGCTTAT
    GTAGTTGAACAACCATCAACGAACCCTGCATTTGCCAACAAAAAATATCGTCTATACGAA
    GGAATTAATAATGGGCAACATGGGCGCATGATTTTACCTCTTCTTAACTTGAAAAATGCA
    CATCTATTTATGATTTCAACATACAACACTATCTCGTTTAGTTCATTTGAAAAATATGGC
    AAAGACACAGATGAAAAACGTGAAAAGTTCAAGAGTGAGATCAATAAACGTGCTAAAGAG
    CAGGTTAATTACTTAGATTTTTGGTCACGTCTTGCTACTGATAATGTCCGTGATAAACTT
    CTTAAGAGTCAAAATGTAGTTCCAACTCCTGTATGGGATAATCATAATAGCCCGAACGGA
    TGGGCTAGTAGACATGGTCATATAGATGGGAAACCGGATTATGCTCCAATTCGTGAGTTC
    TTTGGGCGAATCAATAAGTATCATGGTTACAAATATGGATATGGCGCATATGCATATATT
    TTTGCAGCACCTCAACCGATGGATGCAGTTTATTTCGTTATGACAGATTTAATTAGTGAC
    TTTGGAACATCTGCATTTACACATGAAACTACTCACGTTAATGATCGTATGGCTTACTAT
    GGTGGTCATTGGCATCGTGAAGGTACGGATCTTGAAGCATTTGCTCAGGGGATGTTACAA
    ACGCCATCGGTATCAAATCCAAACGGAGAATATGGCGCATTAGGTCTAAATATGGCGTAT
    GAACGTCAAAATGATGGAAATCAATGGTATAACACAAATCCAAACGACCTTACAACTCGT
    GCAGAAATTGATAACTACATGAAAGGTTTCAACGATACATTAATGCTTCTTGATTACCTT
    GAAGGAGAAGCTGTCCTCAATAAAGCAAATCAAGATTTAAACAACGCTTGGTTCAAAAAA
    GTGGATAAGCAACTTCGTGGAGCTAGTACGAAGAACCAGTATGATAAAGTTCGTGATTTA
    ACGGCAGATGAGAAAAATATCACTCTAAATTCAGTAGATGATTTAGTTGATAATAATTTT
    ATGACGAAACACGGACCTGGAAACAATGTATATGATCCAACTGGGTTCGGAACGGCCTAC
    GTGACTGTACCTATTACTGCAGGTATTTATGGAGGTAACACAAGTGAAGGTGCTCCTGGT
    TCTATGTCATTCAAACATAACACATTCAGAATGTGGGGGTACTACGGATATGAAAAAGGA
    TTCTTAAACTATGCTTCTAACATGCTGAAAAATGAGTCTAGACAGGCTGGTCACAATACT
    CTAGGTGATGATTTCATCATTAAGAAAGTTTCTGATAATAAATTCAGTACATTGGAAGAT
    TGGAAGAAAGCATACTTCAAAGAAGTTGTAGATAAAGCTAAAGCAGGATTTAACCCTGTT
    ACAATCGACGGTACTACATATAGTAGTTACGATGACTTGAAGAACGCATTTGCTGCAGCA
    GTTGAAAAAGATAAAGCTACTCTTAAAAATGGATCAGTTAAATCTGACAATACTGTTGCA
    CTTAAAGAGAAAATATACAAAAAACTTCTTCAACAAACAGATAGCTTTAAAACTTCAATC
    TTTAGATAA
    60
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    2160
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    4140
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    5040
    5100
    5160
    5220
    5280
    5340
    5400
    5460
    5520
    5580
    5640
    5700
    5709

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: T308_RS03165 [old locus tag: T308_03135 ]
  • symbol: T308_RS03165
  • description: G5 domain-containing protein
  • length: 1902
  • theoretical pI: 5.04068
  • theoretical MW: 212160
  • GRAVY: -0.650263

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 26.2)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 757.6)
    and 5 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 296.2)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 78.1)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 29.9)
    E-set (CL0159) fn3; Fibronectin type III domain (PF00041; HMM-score: 13.7)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 10.1)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • SignalP: Signal peptide SP(Sec/SPI) length 33 aa
    • SP(Sec/SPI): 0.98483
    • TAT(Tat/SPI): 0.008282
    • LIPO(Sec/SPII): 0.001095
    • Cleavage Site: CS pos: 33-34. VDA-AT. Pr: 0.9782
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000473000 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVEAEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEPPVEQAKGPEQPVQPTQAEQPRIPKDSSQPEDPKEDRGAEETPKQEDEQPAEAPEIKVEEPVESKEETKTAKGTQEEGKEGQAPVQEVNPEYKVTTGTVEKSTESELDFTTEVVPDDTKYVDEEVVERQGSKGVQVTKTTYETVEVVETDKVLSTTTEVKTPAVPKVVKKGTKPVKGTAVETREEVIPFATKEQEDDTLKRGTRQVAQEGVNGKKQITETYKTIRGEKTNEAPTVEETVLQAPQDEIIKKGTKGLEKPTLEWVKTDKDVLKKSATASYTLNKPDGVEIKSIKVALKDNTGTVIKEVTVEENNLNATLDNLKYYQGYTLSTTMVYNRGEGEETETLEDKEVQLDLKKVEIKNIKETSLMSVDDAGVETDKSLLTEKPTDVAPLYLRVTTHDNKTTRLAVSSVEEVVVDGKTLYKVVAKAPDLVQRREDDTLSEEYVHYFEKQLPKVDNVYYSFNELITDMQKNPTGTFKLGADLNAANTPTPSKSYVTGEFKGKLSSVDGQHYTIHNTARPLFNNIVGGTVKNINLNNVNIDMPWADQIASVANVIKGGSLIENVKVKGNVLGRNWVSGFIDKIDSGGRLVNVAFIGNVTSVGDGDKFLTGIVGENWKGYVEKAYVEANIKGKRAKAAGISYWSQNSGDNNAVGRDGAIKKSVVKGSIDVEKPIEVGGAVGSLNYLGYIEDTVAMMKVKNGEIFYGSHDIDTDPYYTGERVNRNFIVDGVSEGKSSYTYSKQQKRIKSISQEEADKKIKELGITADKFTIIDPIVNKLNNIKQKADTYKDTQDYKADRELTYRNIEKLQPFYNKEWIVDQGNKVPSNSKLLTTEVLSVTGIKSGQFVTDLSDIDKIMIHYSDGAKEELNVTRQESNVQQVREYSITDLDILYTPNMVEKDRAQLMTDVKSKLSSVELESDGVRQLLVKRDTKKDANANSVGRQNGYIRDLFLEESFSEVKANLDKLVKQILENEDHQLNDNELAERALLKKVEDNKAKIMMGLAYLNQYYAFKYDELSIKDIMMFKPDFYGKTASVIDRLINIGSAENNLKGDRTQDAYRGIISGATGKGSLHDFLTYNMKLFTNETDINVWFKKAIEKNAYVVEQPSTNPAFANKKYRLYEGINNGQHGRMILPLLNLKNAHLFMISTYNTISFSSFEKYGKDTDEKREKFKSEINKRAKEQVNYLDFWSRLATDNVRDKLLKSQNVVPTPVWDNHNSPNGWASRHGHIDGKPDYAPIREFFGRINKYHGYKYGYGAYAYIFAAPQPMDAVYFVMTDLISDFGTSAFTHETTHVNDRMAYYGGHWHREGTDLEAFAQGMLQTPSVSNPNGEYGALGLNMAYERQNDGNQWYNTNPNDLTTRAEIDNYMKGFNDTLMLLDYLEGEAVLNKANQDLNNAWFKKVDKQLRGASTKNQYDKVRDLTADEKNITLNSVDDLVDNNFMTKHGPGNNVYDPTGFGTAYVTVPITAGIYGGNTSEGAPGSMSFKHNTFRMWGYYGYEKGFLNYASNMLKNESRQAGHNTLGDDFIIKKVSDNKFSTLEDWKKAYFKEVVDKAKAGFNPVTIDGTTYSSYDDLKNAFAAAVEKDKATLKNGSVKSDNTVALKEKIYKKLLQQTDSFKTSIFR

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Damiana Chiavolini, Guido Memmi, Tiziana Maggi, Francesco Iannelli, Gianni Pozzi, Marco R Oggioni
The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.
BMC Microbiol: 2003, 3;14
[PubMed:12841855] [WorldCat.org] [DOI] (I e)C E Blue, G K Paterson, A R Kerr, M Bergé, J P Claverys, T J Mitchell
ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract.
Infect Immun: 2003, 71(9);4925-35
[PubMed:12933834] [WorldCat.org] [DOI] (P p)

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