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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 20-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN034156
  • locus tag: SPN034156_RS09185 [old locus tag: SPN034156_16580 ]
  • pan locus tag?: PNEUPAN001606000
  • symbol: SPN034156_RS09185
  • pan gene symbol?: zmpB
  • synonym:
  • product: LPXTG cell wall anchor domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN034156_RS09185 [old locus tag: SPN034156_16580 ]
  • symbol: SPN034156_RS09185
  • product: LPXTG cell wall anchor domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 1716442..1721877
  • length: 5436
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021006 (1716442..1721877) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0577 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
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    1801
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    1921
    1981
    2041
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    2521
    2581
    2641
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    2941
    3001
    3061
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    3241
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    3541
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    5401
    GTGTTTAAAAAAGACCGTTTTTCAATTCGTAAGATTAAGGGAGTTGTAGGCTCTGTATTT
    CTTGGAAGCCTTTTGATGGCTCCTTCTGTAGTGGACGCAGCCACCTATCACTATGTAAAT
    AAAGAGATTATTTCACAAGAAGCTAAAGATTTAATTCAGACAGGAAAGCCTGACAGGAAT
    GAAGTTGTATATGGTTTGGTGTATCAAAAAGATCAGTTGCCTCAAACAGGGACAGAAGCA
    TCTGTTTTGACAGCTTTTGGTTTGCTGACTGTTGGGAGCTTGCTTTTAATCTACAAGAGA
    AAGAAAATTGCTAGCGTCTTTCTAGTTGGAGCTATGGGATTGGTAGTTCTTCCTAGTGCA
    GGGGCTGTAGACCCAGTTGCGACCCTAGCGCTGGCTAGTCGAGAGGGTGTTGTTGAAATG
    GATGGCTATCGCTATGTTGGTTATCTATCAGGTGACATCCTCAAAACGCTTGGCTTGGAC
    ACTGTTTTAGAAGAAACCTCAGCAAAACCTGGAGAGGTGACTGTAGTCGAAGTTGAGACT
    CCTCAATCAACAACAAATCAGGAGCAAGCTAGGACAGAAAACCAAGTAGTAGAGACAGAG
    GAAGCTCCAAAAGAAGAAGCACCTAAAACAGAAGAAAGTCCAAAGGAAGAACCAAAATCG
    GAGGTAAAACCTACTGACGACACCCTTCCTAAAGTAGAAGAGGGGAAAGAAGATTCAGCA
    GAACCATCTCCAGTTGAAGAAGTAGGTGGAGAAGTTGAGTCAAAACCAGAGGAAAAAGTA
    GCAGTTAAGCCAGAAAGTCAACCATCAGACAAACCAGCTGAGGAATCAAAAGTTGAACCA
    CAAGTAGAACAAGCAAAAGTCCCAGAACAACCCGTGCAACCTACACAAGCTGAGCAACCA
    AGTACACCAAAAGAATCATCACAACAAGAAAATCCTAAAGAAGATAGGGGAGCGGAAGAG
    ACACCGAAACAAGAAGATGAACAGCCAGCAGAAGCCCCAGAAATCAAGGTTGAAGAACCA
    GTAGAATCAAAAGAGGAGACTGTTAATCAACCTGTTGAACAACCAAAAGTGGAAACGCCT
    GCTGTAGAAAAACAAACGGAACCAACAGAGGAACCAAAAGTTGAAGTAACAAGTATTCCC
    CAAACTACTCGCTATGAGGAAGACCTTACTAAGGAACACGGAACGCGTGAAGTTGTTAAG
    GAAGGTAAGAATGGCAGTAGAACAGTTACTACTCCATATATCTTGAATGCGACAGATGGT
    ACGACTACAGAAGGCACTTCGACAACTGATGAAGCTGAGATGGAGAAAGAGGTTGTTCGT
    GTTGGCACGAAACCCAAAGAAAAATTAGCTCCAGTCTTAAGTTTGACAAGTGTTACAGAT
    AATGCAATGTTGCGTAGTGCGAGACTTACTTATCATTTGGAAAATACAGATAGTGTTGAT
    GTGAAAAAAATTCATGCTGAAATTAAAAATGGCGATAAGGTTGTCAAAACTATTGACTTA
    TCTAAAGAGAGATTATCAGATGCTGTTGACGGTCTTGAACTTTATAAAGATTATAAGATT
    GTGACGAGTATGACCTATGATAGAGGTAATGGTGAAGAAACCTCTACGTTGGAAGAAACT
    CCACTACGATTAGACCTCAAGAAGGTTGAATTGAAAAACATCGGCTCTACTAATCTCGTC
    AAAGTAAATGAGGATGGTACTGAGGTGGCAAGTGACTTCTTAACAAGTAAACCTGTGGAT
    GTGCAGAATTACTACCTCAAAGTAACTTCACGTGATAATAAAGTGTTTCGCCTCACAGTT
    GAAAAAATTGAAGAGGTGACTGAGGAAGGTCAACCACTTTACAAAGTCACTGCTAAGGCT
    CCTAATTTGATTCAGCACACGGATGCGACTAAAATGCAAGACGAATACGTGTATTATATT
    GAAAAAACACGTGCAACAGATGGTGATATTTACTACAACTTTAACGACTTAGTAAACGCC
    ATGAACAAAAACAAAACTGGTACATTCAAACTTGGTGCTGATTTGAACGCTACAGGTGTA
    CCGACACCTGCTAAGTCGTATGTTACAGGTGATTTCCGAGGTACTTTGACAAGTGTTGAT
    GGTGAACATTACACAATTCATAATACAAGTCGCCCATTGTTTAATAATATTATAGGTGGG
    ACTATCAAAGATATTAACCTTGGCAATGTTAATATTCACATGCCATGGGCAAATAACGTT
    GCATCGTTAGCTAATATTATTAAAGGTGGAACCACTATTGAAAATGTCAAAGTTACAGGT
    AATGTTCTTGGTAAAGACTGGGTATCTGGATTTATAGATAAAATAGATAGTGGCGGTACA
    TTGAGAAATGTAGCTTTTATTGGGAATGTGACCTCTGTTGGTACAGGTGGTTCGTTCTTG
    ACTGGTATTGTTGGTGAAAACTGGAAGGGACTGGTAGAACAGGCTTATGTAGATGCCAAT
    ATTCGAGGGAAGAAAGCTAAGGCTGCAGGTATAGCTTACTGGTCGCAAAATGGAGGCGAT
    AACTATGCTGTAGGTAGATATGGAGCAATTAAGAAATCTGTCGTTAAAGGTTCAATAGAT
    GTAGAAAAACCAATTGAAGTTGGTGGCGCTGTTGGAAGTTTAAATTATCTTGGTTATATA
    GAAGACACTGTTGCTATGATGAAAGTTAAGAACGGTGAAATTTTCTACGGTTCGCATGAT
    ATCGATACCGATCCATATTACACAGGAGAACGAGTAAATAGAAATTTCATTGTTGACGGT
    GTAAGTGAAGGTAAATCTTCGTATAAATACTCTAAACAACAAAATCGCATTAAATCAGTA
    TCTCAAGAGGAAGCTGATAAGAAAATTAAAGAATTGGCTATCACAGCAGATAAATATGCA
    ATTACAGAGCCAATTGTAAATAAACTCAACGCTCTCACAACACGTGATAATGAGTATAGA
    ACAACACAAGATTACAAAGCAGACCGTGAACTTGCTTATCGTAATATCGAAAAACTTCAA
    CCATTCTACAATAAAGAGTGGATTGTAGACCAAGGTAATAAAGTTCCATCAAATTCTAAA
    TTATTAACTACAGAAGTATTATCTGTTACAGGTATGAAAGATGGTCAATTTGTGACTGAC
    TTATCAGAAATTGATAAAATTATGATTCACTATGCGGATGGCACCAAAGAAGAAATGAAC
    GTGACAGCGGTTGCTGATTCTAAGGTGAAACAAGTTCGTGAGTATGACGTGACTGATTTG
    GGTGTTGTTTACACTCCGAATATGGTTGATAAAAACCGCGACCAATTGATTGCAGATGTG
    AAAGCGAAATTGTCGTCAGTTGAATTGATTTCCCCTGAAGTTCGTGCTCTTATGGATAAA
    CGTGGTAAAGCTGAAGAAAATACGGAAGGTCGTCAAAATGGATACATTAGAGATCTATTC
    CTTGAAGAAAGCTTTGCTGAAGTGAAAGCTGGTTTGGGTAAATTGGTTAAAGCTTTGGTT
    GAAAACGAAGATTATCAATTAAATAGCGATGAAGCAGCAATGCGCGCGTTAATTAAGAAA
    GTTGAAGACAATAAAGCTAAAATCATGATGGGACTGGCCTACTTAAATCAATATTATAGT
    TTTAAATACGCTGAGTTATCAATTAAAGATATTATGATGTTTAAACCTGATTTTTATGGT
    AAGAATGTTAATGTCTTAGATTTCTTAATCAAAATTGGTTCAAGTGAAAGAAATGTTAAA
    GGTGATAGAACTTTAGAAGCTTATCGTGAAACTATCGGTGGAACAATTGGAATAAATGAA
    TTAAATGGATTCTTACATTACAATATGAAGCTATTTACTAACCATATAGATATAAATGAC
    TGGTTTAAGAAAGCTATTGAAAAGAATGCTTATGTAGTTGAACAACCATCAACGAACCCT
    GCATTTGCCAACAAAAAATATCGTCTATACGAAGGAATTAATAATGGGCAACATGGGCGG
    ATGATTTTACCTCTTCTTAACTTGAAAAATGCACATCTATTTATGATTTCAACATACAAC
    ACTATCTCGTTTAGTTCGTTTGAAAAATATGGCAAAGACACAGATGAAAAACGTGAAAAG
    TTTAAGAGTGAGATCAATAAACGTGCTAAAGAGCAGGTTAATTACTTAGATTTTTGGTCA
    CGTCTTGCTACTGATAATGTCCGTGATAAACTTCTTAAGAGTCAAAATGTAGTTCCAACT
    CCTGTATGGGATAATCATAATAGCCCGAACGGATGGGCTAGTAGACATGGTCATATAGAT
    GGGAAACCGGATTATGCTCCAATTCGTGAGTTCTTTGGGCGAATCAATAAGTATCATGGT
    TACAAATATGGATATGGCGCATATGCATATATTTTTGCAGCACCTCAACCGATGGATGCA
    GTTTATTTCGTTATGACAGATTTAATTAGTGACTTTGGAACATCTGCATTTACACATGAA
    ACTACTCACATTAATGATCGTATGGCTTACTATGGTGGTCATTGGCATCGTGAAGGTACG
    GATCTTGAAGCATTTGCTCAGGGGATGTTACAAACGCCATCGGTATCAAATCCAAACGGA
    GAATATGGCGCATTAGGTCTAAATATGGCGTATGAACGTCAAAATGATGGAAATCAATGG
    TATAATCCAAATCCTAACAAACTTAAATCTCGCGCTGAAATTGATCACTACATGAAGAAC
    TACAATGAAGCTCTTATGATGTTAGATTATCTGGAAGCAGAATCTGTTTTACCTAAATTA
    AAAGGTAACAATGATAGATGGTTCAAGAAAATGGATAAACAAATGCGTAAGGACGGACAA
    CCTCACCAGTTTGACAAAATTCGCGATTTAAATAATGAAGAGAAGAAAATTCAATTAGCT
    TCTATTGAGGATTTAGTTGATAATAACTTTATGACTAAACACGGTGCTCCTGGAAATGGT
    ACATATAACCCATCAGATTTTAGTTCAGCATATGTTAATATGAATATGATGACTGGTGTA
    TACGGAGGTAACTCAAGTGATGGGGCTCCTGGCGCTGCTTCATTTAAACATAATACTTTC
    CGTATGTGGGGATACTTCGGATACGAAAATGGATTCATCGGATATGCCTCTAATAAATAT
    AAAGCCGAAGCCAATAAAGCAGGTCAAACTCTAAGTGATAAATATATCATCAATAAAGTT
    TCTGGTGGTACATTTAATACACTTGAAGCGTGGAAGAAAGAATGGTTTAAACAAATCAAA
    ACTAAAGCTCAAAAAGGATTCACAGCAATTGAAATTGATGGTAAAACTATTGATTCATAT
    GAAAAATTAAAAGACTTATTTGATAAAGCTGTTGAAGAAGATCTTAAAGGAACTGGAACG
    GATAAGACTGTGAAACTTAAAGAAAAAGTATACAAACAACTCCTTAAAAACACAGACGGT
    TTCTCTGGTGATCTATTTACTGCACCACAAGCATAG
    60
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    4140
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    5160
    5220
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    5340
    5400
    5436

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN034156_RS09185 [old locus tag: SPN034156_16580 ]
  • symbol: SPN034156_RS09185
  • description: LPXTG cell wall anchor domain-containing protein
  • length: 1811
  • theoretical pI: 5.19868
  • theoretical MW: 202348
  • GRAVY: -0.637272

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 26.4)
  • TheSEED: see SPN034156_16580
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 758.2)
    and 4 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 283.1)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 29.9)
    Pectate_lyase_5; Putative pectate lyase-like adhesive domain (PF20585; HMM-score: 12)
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 10)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • SignalP: Signal peptide SP(Sec/SPI) length 33 aa
    • SP(Sec/SPI): 0.98483
    • TAT(Tat/SPI): 0.008282
    • LIPO(Sec/SPII): 0.001095
    • Cleavage Site: CS pos: 33-34. VDA-AT. Pr: 0.9782
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_015511370 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMDGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSAEPSPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEPQVEQAKVPEQPVQPTQAEQPSTPKESSQQENPKEDRGAEETPKQEDEQPAEAPEIKVEEPVESKEETVNQPVEQPKVETPAVEKQTEPTEEPKVEVTSIPQTTRYEEDLTKEHGTREVVKEGKNGSRTVTTPYILNATDGTTTEGTSTTDEAEMEKEVVRVGTKPKEKLAPVLSLTSVTDNAMLRSARLTYHLENTDSVDVKKIHAEIKNGDKVVKTIDLSKERLSDAVDGLELYKDYKIVTSMTYDRGNGEETSTLEETPLRLDLKKVELKNIGSTNLVKVNEDGTEVASDFLTSKPVDVQNYYLKVTSRDNKVFRLTVEKIEEVTEEGQPLYKVTAKAPNLIQHTDATKMQDEYVYYIEKTRATDGDIYYNFNDLVNAMNKNKTGTFKLGADLNATGVPTPAKSYVTGDFRGTLTSVDGEHYTIHNTSRPLFNNIIGGTIKDINLGNVNIHMPWANNVASLANIIKGGTTIENVKVTGNVLGKDWVSGFIDKIDSGGTLRNVAFIGNVTSVGTGGSFLTGIVGENWKGLVEQAYVDANIRGKKAKAAGIAYWSQNGGDNYAVGRYGAIKKSVVKGSIDVEKPIEVGGAVGSLNYLGYIEDTVAMMKVKNGEIFYGSHDIDTDPYYTGERVNRNFIVDGVSEGKSSYKYSKQQNRIKSVSQEEADKKIKELAITADKYAITEPIVNKLNALTTRDNEYRTTQDYKADRELAYRNIEKLQPFYNKEWIVDQGNKVPSNSKLLTTEVLSVTGMKDGQFVTDLSEIDKIMIHYADGTKEEMNVTAVADSKVKQVREYDVTDLGVVYTPNMVDKNRDQLIADVKAKLSSVELISPEVRALMDKRGKAEENTEGRQNGYIRDLFLEESFAEVKAGLGKLVKALVENEDYQLNSDEAAMRALIKKVEDNKAKIMMGLAYLNQYYSFKYAELSIKDIMMFKPDFYGKNVNVLDFLIKIGSSERNVKGDRTLEAYRETIGGTIGINELNGFLHYNMKLFTNHIDINDWFKKAIEKNAYVVEQPSTNPAFANKKYRLYEGINNGQHGRMILPLLNLKNAHLFMISTYNTISFSSFEKYGKDTDEKREKFKSEINKRAKEQVNYLDFWSRLATDNVRDKLLKSQNVVPTPVWDNHNSPNGWASRHGHIDGKPDYAPIREFFGRINKYHGYKYGYGAYAYIFAAPQPMDAVYFVMTDLISDFGTSAFTHETTHINDRMAYYGGHWHREGTDLEAFAQGMLQTPSVSNPNGEYGALGLNMAYERQNDGNQWYNPNPNKLKSRAEIDHYMKNYNEALMMLDYLEAESVLPKLKGNNDRWFKKMDKQMRKDGQPHQFDKIRDLNNEEKKIQLASIEDLVDNNFMTKHGAPGNGTYNPSDFSSAYVNMNMMTGVYGGNSSDGAPGAASFKHNTFRMWGYFGYENGFIGYASNKYKAEANKAGQTLSDKYIINKVSGGTFNTLEAWKKEWFKQIKTKAQKGFTAIEIDGKTIDSYEKLKDLFDKAVEEDLKGTGTDKTVKLKEKVYKQLLKNTDGFSGDLFTAPQA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Damiana Chiavolini, Guido Memmi, Tiziana Maggi, Francesco Iannelli, Gianni Pozzi, Marco R Oggioni
The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.
BMC Microbiol: 2003, 3;14
[PubMed:12841855] [WorldCat.org] [DOI] (I e)C E Blue, G K Paterson, A R Kerr, M Bergé, J P Claverys, T J Mitchell
ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract.
Infect Immun: 2003, 71(9);4925-35
[PubMed:12933834] [WorldCat.org] [DOI] (P p)

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