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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 13-DEC-2020

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae SPN994038
  • locus tag: SPN994038_RS03195 [old locus tag: SPN994038_05990 ]
  • pan locus tag?: PNEUPAN001606000
  • symbol: SPN994038_RS03195
  • pan gene symbol?: zmpB
  • synonym:
  • product: LPXTG cell wall anchor domain-containing protein

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPN994038_RS03195 [old locus tag: SPN994038_05990 ]
  • symbol: SPN994038_RS03195
  • product: LPXTG cell wall anchor domain-containing protein
  • replicon: chromosome
  • strand: +
  • coordinates: 601768..607203
  • length: 5436
  • essential: unknown

⊟Accession numbers[edit | edit source]

  • Location: NC_021026 (601768..607203) NCBI
  • BioCyc:
  • MicrobesOnline:
  • PneumoBrowse for strain D39V: SPV_0577 PneumoBrowse

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
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    2221
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    2521
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    2821
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    2941
    3001
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    4441
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    5281
    5341
    5401
    GTGTTTAAAAAAGACCGTTTTTCAATTCGTAAGATTAAGGGAGTTGTAGGCTCTGTATTT
    CTTGGAAGCCTTTTGATGGCTCCTTCTGTAGTGGACGCAGCCACCTATCACTATGTAAAT
    AAAGAGATTATTTCACAAGAAGCTAAAGATTTAATTCAGACAGGAAAGCCTGACAGGAAT
    GAAGTTGTATATGGTTTGGTGTATCAAAAAGATCAGTTGCCTCAAACAGGGACAGAAGCA
    TCTGTTTTGACAGCTTTTGGTTTGCTGACTGTTGGGAGCTTGCTTTTAATCTACAAGAGA
    AAGAAAATTGCTAGCGTCTTTCTAGTTGGAGCTATGGGATTGGTAGTTCTTCCTAGTGCA
    GGGGCTGTAGACCCAGTTGCGACCCTAGCGCTGGCTAGTCGAGAGGGTGTTGTTGAAATG
    GATGGCTATCGCTATGTTGGTTATCTATCAGGTGACATCCTCAAAACGCTTGGCTTGGAC
    ACTGTTTTAGAAGAAACCTCAGCAAAACCTGGAGAGGTGACTGTAGTCGAAGTTGAGACT
    CCTCAATCAACAACAAATCAGGAGCAAGCTAGGACAGAAAACCAAGTAGTAGAGACAGAG
    GAAGCTCCAAAAGAAGAAGCACCTAAAACAGAAGAAAGTCCAAAGGAAGAACCAAAATCG
    GAGGTAAAACCTACTGACGACACCCTTCCTAAAGTAGAAGAGGGGAAAGAAGATTCAGCA
    GAACCATCTCCAGTTGAAGAAGTAGGTGGAGAAGTTGAGTCAAAACCAGAGGAAAAAGTA
    GCAGTTAAGCCAGAAAGTCAACCATCAGACAAACCAGCTGAGGAATCAAAAGTTGAACCA
    CCAGTAGAACAAGCAAAAGTCCCAGAACAACCCGTGCAACCTACACAAGCTGAGCAACCA
    AGTACACCAAAAGAATCATCACAACAAGAAAATCCTAAAGAAGATAGGGGAGCGGAAGAG
    ACACCGAAACAAGAAGATGAACAGCCAGCAGAAGCCCCAGAAATCAAGGTTGAAGAACCA
    GTAGAATCAAAAGAGGAGACTGTTAATCAACCTGTTGAACAACCAAAAGTGGAAACGCCT
    GCTGTAGAAAAACAAACGGAACCAACAGAGGAACCAAAAGTTGAAGTAACAAGTATTCCC
    CAAACTACTCGCTATGAGGAAGACCTTACTAAGGAACACGGAACGCGTGAAGTTGTTAAG
    GAAGGTAAGAATGGCAGTAGAACAGTTACTACTCCATATATCTTGAATGCGACAGATGGT
    ACGACTACAGAAGGCACTTCGACAACTGATGAAGCTGAGATGGAGAAAGAGGTTGTTCGT
    GTTGGCACGAAACCCAAAGAAAAATTAGCTCCAGTCTTAAGTTTGACAAGTGTTACAGAT
    AATGCAATGTTGCGTAGTGCGAGACTTACTTATCATTTGGAAAATACAGATAGTGTTGAT
    GTGAAAAAAATTCATGCTGAAATTAAAAATGGCGATAAGGTTGTCAAAACTATTGACTTA
    TCTAAAGAGAGATTATCAGATGCTGTTGACGGTCTTGAACTTTATAAAGATTATAAGATT
    GTGACGAGTATGACCTATGATAGAGGTAATGGTGAAGAAACCTCTACGTTGGAAGAAACT
    CCACTACGATTAGACCTCAAGAAGGTTGAATTGAAAAACATCGGCTCTACTAATCTCGTC
    AAAGTAAATGAGGATGGTACTGAGGTGGCAAGTGACTTCTTAACAAGTAAACCTGTGGAT
    GTGCAGAATTACTACCTCAAAGTAACTTCACGTGATAATAAAGTGTTTCGCCTCACAGTT
    GAAAAAATTGAAGAGGTGACTGAGGAAGGTCAACCACTTTACAAAGTCACTGCTAAGGCT
    CCTAATTTGATTCAGCACACGGATGCGACTAAAATGCAAGACGAATACGTGTATTATATT
    GAAAAAACACGTGCAACAGATGGTGATATTTACTACAACTTTAACGACTTAGTAAACGCC
    ATGAACAAAAACAAAACTGGTACATTCAAACTTGGTGCTGATTTGAACGCTACAGGTGTA
    CCGACACCTGCTAAGTCGTATGTTACAGGTGATTTCCGAGGTACTTTGACAAGTGTTGAT
    GGTGAACATTACACAATTCATAATACAAGTCGCCCATTGTTTAATAATATTATAGGTGGG
    ACTATCAAAGATATTAACCTTGGCAATGTTAATATTCACATGCCATGGGCAAATAACGTT
    GCATCGTTAGCTAATATTATTAAAGGTGGAACCACTATTGAAAATGTCAAAGTTACAGGT
    AATGTTCTTGGTAAAGACTGGGTATCTGGATTTATAGATAAAATAGATAGTGGCGGTACA
    TTGAGAAATGTAGCTTTTATTGGGAATGTGACCTCTGTTGGTACAGGTGGTTCGTTCTTG
    ACTGGTATTGTTGGTGAAAACTGGAAGGGACTGGTAGAACAGGCTTATGTAGATGCCAAT
    ATTCGAGGGAAGAAAGCTAAGGCTGCAGGTATAGCTTACTGGTCGCAAAATGGAGGCGAT
    AACTATGCTGTAGGTAGATATGGAGCAATTAAGAAATCTGTCGTTAAAGGTTCAATAGAT
    GTAGAAAAACCAATTGAAGTTGGTGGCGCTGTTGGAAGTTTAAATTATCTTGGTTATATA
    GAAGACACTGTTGCTATGATGAAAGTTAAGAACGGTGAAATTTTCTACGGTTCGCATGAT
    ATCGATACCGATCCATATTACACAGGAGAACGAGTAAATAGAAATTTCATTGTTGACGGT
    GTAAGTGAAGGTAAATCTTCGTATAAATACTCTAAACAACAAAATCGCATTAAATCAGTA
    TCTCAAGAGGAAGCTGATAAGAAAATTAAAGAATTGGCTATCACAGCAGATAAATATGCA
    ATTACAGAGCCAATTGTAAATAAACTCAACGCTCTCACAACACGTGATAATGAGTATAGA
    ACAACACAAGATTACAAAGCAGACCGTGAACTTGCTTATCGTAATATCGAAAAACTTCAA
    CCATTCTACAATAAAGAGTGGATTGTAGACCAAGGTAATAAAGTTCCATCAAATTCTAAA
    TTATTAACTACAGAAGTATTATCTGTTACAGGTATGAAAGATGGTCAATTTGTGACTGAC
    TTATCAGAAATTGATAAAATTATGATTCACTATGCGGATGGCACCAAAGAAGAAATGAAC
    GTGACAGCGGTTGCTGATTCTAAGGTGAAACAAGTTCGTGAGTATGACGTGACTGATTTG
    GGTGTTGTTTACACTCCGAATATGGTTGATAAAAACCGCGACCAATTGATTGCAGATGTG
    AAAGCGAAATTGTCGTCAGTTGAATTGATTTCCCCTGAAGTTCGTGCTCTTATGGATAAA
    CGTGGTAAAGCTGAAGAAAATACGGAAGGTCGTCAAAATGGATACATTAGAGATCTATTC
    CTTGAAGAAAGCTTTGCTGAAGTGAAAGCTGGTTTGGGTAAATTGGTTAAAGCTTTGGTT
    GAAAACGAAGATTATCAATTAAATAGCGATGAAGCAGCAATGCGCGCGTTAATTAAGAAA
    GTTGAAGACAATAAAGCTAAAATCATGATGGGACTGGCCTACTTAAATCAATATTATAGT
    TTTAAATACGCTGAGTTATCAATTAAAGATATTATGATGTTTAAACCTGATTTTTATGGT
    AAGAATGTTAATGTCTTAGATTTCTTAATCAAAATTGGTTCAAGTGAAAGAAATGTTAAA
    GGTGATAGAACTTTAGAAGCTTATCGTGAAACTATCGGTGGAACAATTGGAATAAATGAA
    TTAAATGGATTCTTACATTACAATATGAAGCTATTTACTAACCATATAGATATAAATGAC
    TGGTTTAAGAAAGCTATTGAAAAGAATGCTTATGTAGTTGAACAACCATCAACGAACCCT
    GCATTTGCCAACAAAAAATATCGTCTATACGAAGGAATTAATAATGGGCAACATGGGCGG
    ATGATTTTACCTCTTCTTAACTTGAAAAATGCACATCTATTTATGATTTCAACATACAAC
    ACTATCTCGTTTAGTTCGTTTGAAAAATATGGCAAAGACACAGATGAAAAACGTGAAAAG
    TTTAAGAGTGAGATCAATAAACGTGCTAAAGAGCAGGTTAATTACTTAGATTTTTGGTCA
    CGTCTTGCTACTGATAATGTCCGTGATAAACTTCTTAAGAGTCAAAATGTAGTTCCAACT
    CCTGTATGGGATAATCATAATAGCCCGAACGGATGGGCTAGTAGACATGGTCATATAGAT
    GGGAAACCGGATTATGCTCCAATTCGTGAGTTCTTTGGGCGAATCAATAAGTATCATGGT
    TACAAATATGGATATGGCGCATATGCATATATTTTTGCAGCACCTCAACCGATGGATGCA
    GTTTATTTCGTTATGACAGATTTAATTAGTGACTTTGGAACATCTGCATTTACACATGAA
    ACTACTCACATTAATGATCGTATGGCTTACTATGGTGGTCATTGGCATCGTGAAGGTACG
    GATCTTGAAGCATTTGCTCAGGGGATGTTACAAACGCCATCGGTATCAAATCCAAACGGA
    GAATATGGCGCATTAGGTCTAAATATGGCGTATGAACGTCAAAATGATGGAAATCAATGG
    TATAATCCAAATCCTAACAAACTTAAATCTCGCGCTGAAATTGATCACTACATGAAGAAC
    TACAATGAAGCTCTTATGATGTTAGATTATCTGGAAGCAGAATCTGTTTTACCTAAATTA
    AAAGGTAACAATGATAGATGGTTCAAGAAAATGGATAAACAAATGCGTAAGGACGGACAA
    CCTCACCAGTTTGACAAAATTCGCGATTTAAATAATGAAGAGAAGAAAATTCAATTAGCT
    TCTATTGAGGATTTAGTTGATAATAACTTTATGACTAAACACGGTGCTCCTGGAAATGGT
    ACATATAACCCATCAGATTTTAGTTCAGCATATGTTAATATGAATATGATGACTGGTGTA
    TACGGAGGTAACTCAAGTGATGGGGCTCCTGGCGCTGCTTCATTTAAACATAATACTTTC
    CGTATGTGGGGATACTTCGGATACGAAAATGGATTCATCGGATATGCCTCTAATAAATAT
    AAAGCCGAAGCCAATAAAGCAGGTCAAACTCTAAGTGATAAATATATCATCAATAAAGTT
    TCTGGTGGTACATTTAATACACTTGAAGCGTGGAAGAAAGAATGGTTTAAACAAATCAAA
    ACTAAAGCTCAAAAAGGATTCACAGCAATTGAAATTGATGGTAAAACTATTGATTCATAT
    GAAAAATTAAAAGACTTATTTGATAAAGCTGTTGAAGAAGATCTTAAAGGAACTGGAACG
    GATAAGACTGTGAAACTTAAAGAAAAAGTATACAAACAACTCCTTAAAAACACAGACGGT
    TTCTCTGGTGATCTATTTACTGCACCACAAGCATAG
    60
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    5100
    5160
    5220
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    5340
    5400
    5436

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPN994038_RS03195 [old locus tag: SPN994038_05990 ]
  • symbol: SPN994038_RS03195
  • description: LPXTG cell wall anchor domain-containing protein
  • length: 1811
  • theoretical pI: 5.19868
  • theoretical MW: 202317
  • GRAVY: -0.636223

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 26.4)
  • TheSEED: data available for D39, Hungary19A-6, TIGR4
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 758.2)
    and 4 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 283.1)
    Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 29.9)
    Pectate_lyase_5; Putative pectate lyase-like adhesive domain (PF20585; HMM-score: 12)
    YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 10)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • SignalP: Signal peptide SP(Sec/SPI) length 33 aa
    • SP(Sec/SPI): 0.98483
    • TAT(Tat/SPI): 0.008282
    • LIPO(Sec/SPII): 0.001095
    • Cleavage Site: CS pos: 33-34. VDA-AT. Pr: 0.9782
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

  • GI:
  • RefSeq: WP_000472976 NCBI
  • UniProt:

⊟Protein sequence[edit | edit source]

  • MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMDGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSAEPSPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEPPVEQAKVPEQPVQPTQAEQPSTPKESSQQENPKEDRGAEETPKQEDEQPAEAPEIKVEEPVESKEETVNQPVEQPKVETPAVEKQTEPTEEPKVEVTSIPQTTRYEEDLTKEHGTREVVKEGKNGSRTVTTPYILNATDGTTTEGTSTTDEAEMEKEVVRVGTKPKEKLAPVLSLTSVTDNAMLRSARLTYHLENTDSVDVKKIHAEIKNGDKVVKTIDLSKERLSDAVDGLELYKDYKIVTSMTYDRGNGEETSTLEETPLRLDLKKVELKNIGSTNLVKVNEDGTEVASDFLTSKPVDVQNYYLKVTSRDNKVFRLTVEKIEEVTEEGQPLYKVTAKAPNLIQHTDATKMQDEYVYYIEKTRATDGDIYYNFNDLVNAMNKNKTGTFKLGADLNATGVPTPAKSYVTGDFRGTLTSVDGEHYTIHNTSRPLFNNIIGGTIKDINLGNVNIHMPWANNVASLANIIKGGTTIENVKVTGNVLGKDWVSGFIDKIDSGGTLRNVAFIGNVTSVGTGGSFLTGIVGENWKGLVEQAYVDANIRGKKAKAAGIAYWSQNGGDNYAVGRYGAIKKSVVKGSIDVEKPIEVGGAVGSLNYLGYIEDTVAMMKVKNGEIFYGSHDIDTDPYYTGERVNRNFIVDGVSEGKSSYKYSKQQNRIKSVSQEEADKKIKELAITADKYAITEPIVNKLNALTTRDNEYRTTQDYKADRELAYRNIEKLQPFYNKEWIVDQGNKVPSNSKLLTTEVLSVTGMKDGQFVTDLSEIDKIMIHYADGTKEEMNVTAVADSKVKQVREYDVTDLGVVYTPNMVDKNRDQLIADVKAKLSSVELISPEVRALMDKRGKAEENTEGRQNGYIRDLFLEESFAEVKAGLGKLVKALVENEDYQLNSDEAAMRALIKKVEDNKAKIMMGLAYLNQYYSFKYAELSIKDIMMFKPDFYGKNVNVLDFLIKIGSSERNVKGDRTLEAYRETIGGTIGINELNGFLHYNMKLFTNHIDINDWFKKAIEKNAYVVEQPSTNPAFANKKYRLYEGINNGQHGRMILPLLNLKNAHLFMISTYNTISFSSFEKYGKDTDEKREKFKSEINKRAKEQVNYLDFWSRLATDNVRDKLLKSQNVVPTPVWDNHNSPNGWASRHGHIDGKPDYAPIREFFGRINKYHGYKYGYGAYAYIFAAPQPMDAVYFVMTDLISDFGTSAFTHETTHINDRMAYYGGHWHREGTDLEAFAQGMLQTPSVSNPNGEYGALGLNMAYERQNDGNQWYNPNPNKLKSRAEIDHYMKNYNEALMMLDYLEAESVLPKLKGNNDRWFKKMDKQMRKDGQPHQFDKIRDLNNEEKKIQLASIEDLVDNNFMTKHGAPGNGTYNPSDFSSAYVNMNMMTGVYGGNSSDGAPGAASFKHNTFRMWGYFGYENGFIGYASNKYKAEANKAGQTLSDKYIINKVSGGTFNTLEAWKKEWFKQIKTKAQKGFTAIEIDGKTIDSYEKLKDLFDKAVEEDLKGTGTDKTVKLKEKVYKQLLKNTDGFSGDLFTAPQA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Damiana Chiavolini, Guido Memmi, Tiziana Maggi, Francesco Iannelli, Gianni Pozzi, Marco R Oggioni
The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.
BMC Microbiol: 2003, 3;14
[PubMed:12841855] [WorldCat.org] [DOI] (I e)C E Blue, G K Paterson, A R Kerr, M Bergé, J P Claverys, T J Mitchell
ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract.
Infect Immun: 2003, 71(9);4925-35
[PubMed:12933834] [WorldCat.org] [DOI] (P p)

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