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PangenomeTIGR4
serotype 4
D39
serotype 2
D39V
serotype 2
Hungary19A-6
serotype 19A
EF3030
serotype 19F
670-6B
serotype 6B
6A-10
serotype 6A
70585
serotype 5
A026
serotype 19F
A66
serotype 3
AP200
serotype 11A
ASP0581
serotype 12F
ATCC 49619
serotype 19F
ATCC 700669
serotype 23F
BVJ1JL
serotype 1
CGSP14
serotype 14
G54
serotype 19F
HU-OH
serotype 3
Hu15
serotype 19A
Hu17
serotype 19A
INV104
serotype 1
INV200
serotype 14
JJA
serotype 14
MDRSPN001
serotype 19F
NCTC7466
serotype 2
NU83127
serotype 4
OXC141
serotype 3
P1031
serotype 1
R6
serotype 2
SP49
serotype 19A
SPN032672
serotype 1
SPN034156
serotype 3
SPN034183
serotype 3
SPN994038
serotype 3
SPN994039
serotype 3
SPNA45
serotype 3
ST556
serotype 19F
TCH8431/19A
serotype 19A
Taiwan19F-14
serotype 19F
Xen35
serotype 4
gamPNI0373
serotype 1

NCBI: 31-JAN-2014

⊟Summary[edit | edit source]

  • organism: Streptococcus pneumoniae Hungary19A-6
  • locus tag: SPH_0759 [new locus tag: SPH_RS03685 ]
  • pan locus tag?: PNEUPAN001606000
  • symbol: zmpB
  • pan gene symbol?: zmpB
  • synonym:
  • product: zinc metalloprotease ZmpB

⊟Genome View[edit | edit source]

⊟Gene[edit | edit source]

⊟General[edit | edit source]

  • type: CDS
  • locus tag: SPH_0759 [new locus tag: SPH_RS03685 ]
  • symbol: zmpB
  • product: zinc metalloprotease ZmpB
  • replicon: chromosome
  • strand: +
  • coordinates: 709544..715246
  • length: 5703
  • essential: unknown

⊟Accession numbers[edit | edit source]

⊟Phenotype[edit | edit source]

Share your knowledge and add information here. [edit]

⊟DNA sequence[edit | edit source]

  • 1
    61
    121
    181
    241
    301
    361
    421
    481
    541
    601
    661
    721
    781
    841
    901
    961
    1021
    1081
    1141
    1201
    1261
    1321
    1381
    1441
    1501
    1561
    1621
    1681
    1741
    1801
    1861
    1921
    1981
    2041
    2101
    2161
    2221
    2281
    2341
    2401
    2461
    2521
    2581
    2641
    2701
    2761
    2821
    2881
    2941
    3001
    3061
    3121
    3181
    3241
    3301
    3361
    3421
    3481
    3541
    3601
    3661
    3721
    3781
    3841
    3901
    3961
    4021
    4081
    4141
    4201
    4261
    4321
    4381
    4441
    4501
    4561
    4621
    4681
    4741
    4801
    4861
    4921
    4981
    5041
    5101
    5161
    5221
    5281
    5341
    5401
    5461
    5521
    5581
    5641
    5701
    GTGTTTAAAAAAGACCGTTTTTCAATTCGTAAGATTAAGGGAGTTGTAGGCTCTGTATTT
    CTTGGAAGCCTTTTGATGGCTCCTTCTGTAGTGGACGCAGCTACCTATCACTATGTAAAT
    AAAGAGATTATTTCACAAGAAGCTAAAGATTTAATTCAGACAGGAAAGCCTGACAGGAAT
    GAAGTTGTATATGGTTTGGTGTATCAAAAAGATCAGTTGCCTCAAACAGGGACAGAAGCA
    TCTGTTTTGACAGCTTTTGGTTTGCTGACTGTTGGGAGCTTGCTTTTAATCTACAAGAGA
    AAGAAAATTGCTAGCGTCTTTCTAGTTGGAGCTATGGGATTGGTAGTTCTTCCTAGTGCA
    GGGGCTGTAGACCCAGTTGCGACCCTAGCGCTGGCTAGTCGAGAGGGTGTTGTTGAAATG
    GATGGCTATCGCTATGTTGGTTATCTATCAGGTGACATCCTCAAAACGCTTGGCTTGGAC
    ACTGTTTTAGAAGAAACCTCAGCAAAACCTGGAGAGGTGACTGTAGTCGAAGTTGAGACT
    CCTCAATCAACAACAAATCAGGAGCAAGCTAGGACAGAAAACCAAGTAGTAGAGACAGAG
    GAAGCTCCAAAAGAAGAAGCACCTAGAACAGAAGAAAGTCCAAAGGAAGAACCAAAATCG
    GAGGTAAAACCTACTGACGACACCCTTCCTAAAGTAGAAGAGGGGAAAGAAGATTCAGCA
    GAACCAGCTCCAGTTGAAGAAGTAGGTGGAGAAGTTGAGTCAAAACCAGAGGAAAAAGTA
    GCAGTTAAGCCAGAAAGTCAACCATCAGACAAACCAGCTGAGGAATCAAAAGTTGAACCA
    CCAGTAGAACAAGCAAAAGTCCCAGAACAACCCGTGCAACCTACACAAGCTGAGCAACCA
    AGTACACCAAAAGAATCATCACAACAAGAAAATCCTAAAGAAGATAGGGGAGCGGAAGAG
    ACACCGAAACAAGAAGATGAACAGCCAGCAGAAGCCCCAGAAATCAAGGTTGAAGAACCA
    GTAGAATCAAAAGAGGAGACTAAAACAGCTAAGGGGACGCAAGAAGAAGGCAAAGAAGGT
    CAAGCACCAGTACAAGAAGTAAACCCAGAATATAAAGTAACAACAGGTACAGTTGAGAAG
    TCTACCGAAAGTGAATTAGATTTCACAACAGAAGTAGTTCCGGATGACACAAAATATGTA
    GATGAAGAAGTTGTTGAACGTCAAGGGTCTAAAGGAGTTCAAGTTACGAAAACAACTTAC
    GAAACAGTGGAAGTTGTAGAGACAGACAAAGTCCTTTCTACAACTACAGAAGTGAAAACT
    CCTGTTGTTCCTAAAGTCGTTAAAAAAGGAACAAAACCAGTTGAAGGAACAGCAGTTGAA
    ACAAGAGAAGAAGTCATTCCTTTTGCTACAAAAGAACAAGAAGATGGCACTTTAAAACGC
    GGAACAAGACAAGTAGCTCAAGAAGGTGTAAACGGTAAGAAACAAATTACTGAAACCTAT
    AAAACAATTCGCGGAGAAAAAACAAACGAAGCTCCAACAGTAGAAGAAACAGTTCTCCAA
    GCACCTCAAGATGAGATTATCAAAAAAGGCACAAAAGGTTTAGAAAAACCAACCTTAGAA
    TGGGTTAAAACAGATAAAGATGTCTTGAAGAAGAGTGCGACAGCCAGTTATACATTGAAT
    AAACCAGATGGGGTAGAAATCAAATCCATCAAAGTAGCTCTAAAAGATAATACTGGAACA
    GTTATTAAAGAAGTAACGGTAGAAGAAAATAACTTAAACGTTACTTTAGACAACTTGAAA
    TATTATCAAGGTTATACACTATCCACAACCATGGTCTATAATCGAGGCGAAGGCGAAGAA
    ACTGAAACGTTAGAAGATAAAGAAGTTCAGTTAGACCTTAAAAAAGTTGAAATCAAAAAC
    ATCAAAGAAACTAGCTTGATGAGTGTGGATGATGCTGGTGTTGAAACAGATAAGAGCTTA
    CTTACTGAAAAACCGACAGACGTTGCTCCACTTTACCTACGAGTGACAACTCATGATAAC
    AAAGTAACAAGACTTGCTGTTGATAAGATTGAAGAAGTAGAAGAAGACGGAAAAACTTTA
    TACAAAGTTACTGCCAAAGCACCAGACTTAGTTCAACGTAATGCTGATAACACACTTAGC
    GAAGAGTATGTTCATTACTTTGAAAAACAACTTCCAAAAATTGGAAATGTGTATTACAAC
    TTCAACGAGTTGATTACAGATATGCAAAAAACACCGAATGGCGAGTTTAAACTTGGTGCA
    GACTTGAATGCTGTCAATGTTCCAACACCAAATAAATCTTATGTGACTGCTAAATTTACT
    GGTAAGTTGTATAGTGAAGGTGATAAACACTATACTATTCACAACTTAGCACGTCCATTG
    TTTGCGCAAGCTGAAAACGCTCATATTCATGACATCAACCTCGGTAATGTAAATATTAAT
    ATGCCGTGGGCGAACAAAACAGCACCTCTTGGTGAAATGTTCAAGAAGTCAACTATTGAA
    AACGTCAAAGTAACAGGTAATGTTGTCGGTAACAATGACGTTACAGGTATGGTCAACAAA
    CTGGACGAATCTGATATGCGTAACGTAGCTTTCATTGGAAATATTACAAGTGTAGGTAGC
    GCTGGATGGTGGTCTGGTGGACTTGTCAGTGAAAGCTGGAGAAGTAACACAGATAATTCT
    TATATTGATACCACCATCAAAGGTAATAAAGCTAAGGTAGGTGGATTAATTGCTAAGTTA
    AATCACGGTGCTGACCCACGAGATGTTGGTGCGAGAGGTCGTTTGAAGAACTCTGTCGCA
    AAAGGTACTATTGATGTGAGAGACCCACAAGAAACTGGTGGATTGCTGCATTCTAACTGG
    TCATGGGGTCTTGCAGAAAACAATATTACCATGATGAAAGTGAAGAATGGAGGAGAAATT
    TTATATGGTTCTCGTGATGCAGAAGATGATGATTACTTCGGAGCGAATTGGGTGCGTAAT
    AATAATGCGTTCGTCAATGGAATCAGTGAAGGGAAACAATCCTATTCTCGTTCTAGTCGC
    TGGAAAGGGATTTCTGAAGATGAAGCTAAAACTCGTATTGCCAAAATGGGAATTACAGCT
    CATGAATACGAAATTACACAACATTTGACTGATAAATTGAACCGTGCAGCATTTAAAGAA
    GACACATATAAAACAACTCAAGATTACAAAACTGAAAGAGAATTAGCGTATCGTAATATT
    GAAAAGCTTCAACCATTCTACAATAAAGAATGGATTATCAACCAAGGTAACAAATTAACA
    GACGGTTCAAACTTAATGATTAAAGAGGTATTGTCCGTTATAGGTATGAAGAACGGTCAG
    TTCGTGACCGATTTGTCTGATATTGATAAGATTATGATTCACTACGCTGATGGTACGAAA
    GAAGAAAAAACTGTCACACGTAAAGCTGACTCAAAAGTGCAACAAATTCGTGAATATAGT
    GTTGAAGGTCTTGGTGATGTTGTGTACACACCAAATATGGTCGAAAAAGATAGAGCGCAA
    TTAATTACTGATATTAAGGCGAAATTGGATAGCGTCCAATTGATTTCACCAGAAGTGCGC
    AATTTGATGGATAAACGTGGCAAAGCGCATGAAAACACGGATGAACGTCGTAATGGCTAC
    ATTCGAAACCTATTCCTTGAAGAAAGTTTGGATGAAGTGAAAGGAAACCTTGATAAGCTT
    GTGAAAGCTCTTGTTGAAAATGAAGACCATCAATTGAATGGTGATGAAGCGGCAATGAAA
    GCTCTTGTCAAGAAAGTTGAAGACAACAAAGCGAAAATCATGTTAGGTCTTGCTTATCTC
    AATCGCTACTATGGATTCAAATATGACGAAAAGTCTATGAAGGATATTATGATGTTCAAA
    CCGGACTTCTATGGTAAGAATGTTAGTGTCTTGGACTTCTTGATTAGAGTTGGTTCAAGA
    GAACACAATATTAAAGGTAACAGAACGTTAGAAGCTTATCGTGAAGTAATTGGTGGAACG
    ATTGGTATCGGTGAGTTAAACGGTTTCTTAAACTATAATATGCGTTTATTCACAGAAGAA
    ACTGACATCAATACTTGGTACAAAAAAGCTGTATCGCATACCAACTATATTGTTGAAAAA
    CAATCCTCAAACCCTGCGTTTGCCAACAAGAAATATCGCCTTTATGAAAACTTGAACAAT
    GGTGAACATGGTAAATATATTTTACCACTTCTCACTACGAAGAAAGCTCATATGTTCTTG
    ATTTCAACCTATAATACATTAGCGTTTAGTGCGTTTGAGAAATATGGTAAGAATACAGAA
    GCTGAACGTGAAGCGTTTAAGAAAGAAATCGATTTACGTGCTCAAGAGCAAATTAATTAC
    TTAGACTTCTGGTCAAGACTTGCAGCTGATAATGTACGTGACAGATTGTTAAAATCTGAA
    AATATGGTTCCGTCTGCAATTTGGGATAACCAAGAAGTTCCAGGTCATGGATGGGCTGAT
    AGAATGGGTCATAATAAGAATGGTGACTATGCTCCGGTTCGTGAGTTCTATGGACCTACA
    GGTAAATGGCATGGATACAATGGTACGGGTGCATATGCTTATATCTTTACTAATCCACAA
    AACTCAGAAGCTGTATATTATATCATATCTAGTATGATCAGTGATTTCGGTACTTCTGCA
    TTCACTCATGAAACTACACACATTAATGACCGTATGGCGTATCTAGGTGGATGGCGTCAC
    CGTGAAGGTACTGACGTAGAAGCATTTGCCCAAGGTATGTTACAATCACCGGCTGTCTCA
    AGTCCGAACGGCGACTACGGTGCTTTAGGTCTTAACATGGCTTACAAACGTGAAAACGAT
    GGTAACCAATGGTACAACTATGATTCAAATAAATTAGATAGTCGTGCGAAGATTGACCAT
    TACATGAAGAATTACAACGAAGCGCTCATGATGCTTGACCACTTAGAAGCTGATGCCGTT
    ATCGCGAAGAATAACGGAGATAACAACAAGTGGTTCAAGAAGATGGATAAGAAATGGCGT
    GAGAACGCTAATCGAAATGGATTAGTGGGACAACCACACCAATGGGATTTACTTCGTGAC
    CTAAATGAAGAAGAGAATAAGAAGAAATTGACAAGCATTGATGACCTTGTAGATGGAAAT
    TATGTAACGAAGCATAATATGCCGGGTAATAAACACTATCGTGCTGAAGGGTTTGATACA
    GCGTATCAAACTGTAAACATGATGGCTGGTATTTACGGTGGTAATACTAGTAAGAGTGCT
    GTTGGTTCTATCTCGTTCAAACATAACACCTTCCGTATGTGGGGTTACTTCGGTTATCTT
    GATGGATTTGTAGGTTATGCATCTAACAAATATAAAGACGCGGCTAACAAAGAAAATAAA
    GGCTTACTTGGCGACGACTTTATTATCAAGAAAGTGTCTGACGGTAAATTTGACAGCCTA
    GAAGCTTGGAAGAAAGAATGGTTTAAAGAAGTTAAAGCTAAAGGTGAAAAAGGATTTGTT
    GCTATTGAAATTGATGGTAAAACAATCACTAACTATGCTGAACTTCGTGAATTGTTCGAC
    AAAGCTGTTGAAGCTGACCTGAAAGCTGGTAACTCTAACCAAACAGTTGCCCTTAAAGAA
    AAGGTTTATAAACAACTCTTGCAGAAATCAGATGGATTTGTAGGAAATCTTTTTAAAGCA
    TAG
    60
    120
    180
    240
    300
    360
    420
    480
    540
    600
    660
    720
    780
    840
    900
    960
    1020
    1080
    1140
    1200
    1260
    1320
    1380
    1440
    1500
    1560
    1620
    1680
    1740
    1800
    1860
    1920
    1980
    2040
    2100
    2160
    2220
    2280
    2340
    2400
    2460
    2520
    2580
    2640
    2700
    2760
    2820
    2880
    2940
    3000
    3060
    3120
    3180
    3240
    3300
    3360
    3420
    3480
    3540
    3600
    3660
    3720
    3780
    3840
    3900
    3960
    4020
    4080
    4140
    4200
    4260
    4320
    4380
    4440
    4500
    4560
    4620
    4680
    4740
    4800
    4860
    4920
    4980
    5040
    5100
    5160
    5220
    5280
    5340
    5400
    5460
    5520
    5580
    5640
    5700
    5703

⊟Protein[edit | edit source]

⊟General[edit | edit source]

  • locus tag: SPH_0759 [new locus tag: SPH_RS03685 ]
  • symbol: ZmpB
  • description: zinc metalloprotease ZmpB
  • length: 1900
  • theoretical pI: 5.19416
  • theoretical MW: 212993
  • GRAVY: -0.705526

⊟Function[edit | edit source]

  • TIGRFAM:
    Cell structure Cell envelope Other LPXTG cell wall anchor domain (TIGR01167; HMM-score: 26.3)
  • TheSEED  :
    • Zinc metalloprotease zmpB precursor (EC 3.4.24.-)
  • PFAM:
    no clan defined Peptidase_M26_C; M26 IgA1-specific Metallo-endopeptidase C-terminal region (PF07580; HMM-score: 796)
    and 5 more
    Peptidase_M26_N; M26 IgA1-specific Metallo-endopeptidase N-terminal region (PF05342; HMM-score: 284.1)
    G5 (CL0593) G5; G5 domain (PF07501; HMM-score: 72.5)
    no clan defined Gram_pos_anchor; LPXTG cell wall anchor motif (PF00746; HMM-score: 30)
    E-set (CL0159) fn3; Fibronectin type III domain (PF00041; HMM-score: 15.6)
    no clan defined YSIRK_signal; YSIRK type signal peptide (PF04650; HMM-score: 10)

⊟Structure, modifications & cofactors[edit | edit source]

  • domains:
  • modifications:
  • cofactors:
  • effectors:

⊟Localization[edit | edit source]

  • PSORTb: Cellwall
    • Cytoplasmic Score: 0
    • Cytoplasmic Membrane Score: 0
    • Cellwall Score: 10
    • Extracellular Score: 0
    • Internal Helices: 2
  • SignalP: Signal peptide SP(Sec/SPI) length 33 aa
    • SP(Sec/SPI): 0.98483
    • TAT(Tat/SPI): 0.008282
    • LIPO(Sec/SPII): 0.001095
    • Cleavage Site: CS pos: 33-34. VDA-AT. Pr: 0.9782
  • predicted transmembrane helices (TMHMM): 3

⊟Accession numbers[edit | edit source]

⊟Protein sequence[edit | edit source]

  • MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMDGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVETEEAPKEEAPRTEESPKEEPKSEVKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEPPVEQAKVPEQPVQPTQAEQPSTPKESSQQENPKEDRGAEETPKQEDEQPAEAPEIKVEEPVESKEETKTAKGTQEEGKEGQAPVQEVNPEYKVTTGTVEKSTESELDFTTEVVPDDTKYVDEEVVERQGSKGVQVTKTTYETVEVVETDKVLSTTTEVKTPVVPKVVKKGTKPVEGTAVETREEVIPFATKEQEDGTLKRGTRQVAQEGVNGKKQITETYKTIRGEKTNEAPTVEETVLQAPQDEIIKKGTKGLEKPTLEWVKTDKDVLKKSATASYTLNKPDGVEIKSIKVALKDNTGTVIKEVTVEENNLNVTLDNLKYYQGYTLSTTMVYNRGEGEETETLEDKEVQLDLKKVEIKNIKETSLMSVDDAGVETDKSLLTEKPTDVAPLYLRVTTHDNKVTRLAVDKIEEVEEDGKTLYKVTAKAPDLVQRNADNTLSEEYVHYFEKQLPKIGNVYYNFNELITDMQKTPNGEFKLGADLNAVNVPTPNKSYVTAKFTGKLYSEGDKHYTIHNLARPLFAQAENAHIHDINLGNVNINMPWANKTAPLGEMFKKSTIENVKVTGNVVGNNDVTGMVNKLDESDMRNVAFIGNITSVGSAGWWSGGLVSESWRSNTDNSYIDTTIKGNKAKVGGLIAKLNHGADPRDVGARGRLKNSVAKGTIDVRDPQETGGLLHSNWSWGLAENNITMMKVKNGGEILYGSRDAEDDDYFGANWVRNNNAFVNGISEGKQSYSRSSRWKGISEDEAKTRIAKMGITAHEYEITQHLTDKLNRAAFKEDTYKTTQDYKTERELAYRNIEKLQPFYNKEWIINQGNKLTDGSNLMIKEVLSVIGMKNGQFVTDLSDIDKIMIHYADGTKEEKTVTRKADSKVQQIREYSVEGLGDVVYTPNMVEKDRAQLITDIKAKLDSVQLISPEVRNLMDKRGKAHENTDERRNGYIRNLFLEESLDEVKGNLDKLVKALVENEDHQLNGDEAAMKALVKKVEDNKAKIMLGLAYLNRYYGFKYDEKSMKDIMMFKPDFYGKNVSVLDFLIRVGSREHNIKGNRTLEAYREVIGGTIGIGELNGFLNYNMRLFTEETDINTWYKKAVSHTNYIVEKQSSNPAFANKKYRLYENLNNGEHGKYILPLLTTKKAHMFLISTYNTLAFSAFEKYGKNTEAEREAFKKEIDLRAQEQINYLDFWSRLAADNVRDRLLKSENMVPSAIWDNQEVPGHGWADRMGHNKNGDYAPVREFYGPTGKWHGYNGTGAYAYIFTNPQNSEAVYYIISSMISDFGTSAFTHETTHINDRMAYLGGWRHREGTDVEAFAQGMLQSPAVSSPNGDYGALGLNMAYKRENDGNQWYNYDSNKLDSRAKIDHYMKNYNEALMMLDHLEADAVIAKNNGDNNKWFKKMDKKWRENANRNGLVGQPHQWDLLRDLNEEENKKKLTSIDDLVDGNYVTKHNMPGNKHYRAEGFDTAYQTVNMMAGIYGGNTSKSAVGSISFKHNTFRMWGYFGYLDGFVGYASNKYKDAANKENKGLLGDDFIIKKVSDGKFDSLEAWKKEWFKEVKAKGEKGFVAIEIDGKTITNYAELRELFDKAVEADLKAGNSNQTVALKEKVYKQLLQKSDGFVGNLFKA

⊟Experimental data[edit | edit source]

  • protein localization:
  • interaction partners:

⊟Expression & Regulation[edit | edit source]

⊟Operon[edit | edit source]

⊟Regulation[edit | edit source]

  • regulator:

⊟Expression data[edit | edit source]

⊟Biological Material[edit | edit source]

⊟Mutants[edit | edit source]

⊟Expression vector[edit | edit source]

⊟lacZ fusion[edit | edit source]

⊟GFP fusion[edit | edit source]

⊟two-hybrid system[edit | edit source]

⊟FLAG-tag construct[edit | edit source]

⊟Antibody[edit | edit source]

⊟Other Information[edit | edit source]

You are kindly invited to share additional interesting facts.

⊟Literature[edit | edit source]

⊟References[edit | edit source]

⊟Relevant publications[edit | edit source]

Damiana Chiavolini, Guido Memmi, Tiziana Maggi, Francesco Iannelli, Gianni Pozzi, Marco R Oggioni
The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice.
BMC Microbiol: 2003, 3;14
[PubMed:12841855] [WorldCat.org] [DOI] (I e)C E Blue, G K Paterson, A R Kerr, M Bergé, J P Claverys, T J Mitchell
ZmpB, a novel virulence factor of Streptococcus pneumoniae that induces tumor necrosis factor alpha production in the respiratory tract.
Infect Immun: 2003, 71(9);4925-35
[PubMed:12933834] [WorldCat.org] [DOI] (P p)

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